PPARG_HUMAN

Id Accession code Description Family Species Links
PPARG_HUMAN P37231
Peroxisome proliferator-activated receptor gamma
PPAR-gamma
Nuclear receptor subfamily 1 group C member 3
 1C3 PPAR gamma Homo sapiens UniProt
Chembl
Ensembl

Sequence

Sequence

This panel shows the sequence of the current proteins. All residues are clickable, the link will take you to a page that lists all available information for that residue, such as mutations and oligomer interface elements.
Hovering your mouse over a residue will display some additional inforation such as residue numbers in a number of residue numbering schemes.

show helices (blue)
show mutations in this protein (red)
show other mutations in family (yellow)
M G E T L G D S P I
10		 D P E S D S F T D T
20		 L S A N I S Q E M T
30		 M V D T E M P F W P
40		 T N F G I S S V D L
50		 S V M E D H S H S F
60		 D I K P F T T V D F
70		 S S I S T P H Y E D
80		 I P F T R T D P V V
90		 A D Y K Y D L K L Q
100
E Y Q S A I K V E P
110		 A S P P Y Y S E K T
120		 Q L Y N K P H E E P
130		 S N S L M A I E C R
140		 V C G D K A S G F H
150		 Y G V H A C E G C K
160		 G F F R R T I R L K
170		 L I Y D R C D L N C
180		 R I H K K S R N K C
190		 Q Y C R F Q K C L A
200
V G M S H N A I R F
210		 G R M P Q A E K E K
220		 L L A E I S S D I D
230		 Q L N P E S A D L R
240		 A L A K H L Y D S Y
250		 I K S F P L T K A K
260		 A R A I L T G K T T
270		 D K S P F V I Y D M
280		 N S L M M G E D K I
290		 K F K H I T P L Q E
300
Q S K E V A I R I F
310		 Q G C Q F R S V E A
320		 V Q E I T E Y A K S
330		 I P G F V N L D L N
340		 D Q V T L L K Y G V
350		 H E I I Y T M L A S
360		 L M N K D G V L I S
370		 E G Q G F M T R E F
380		 L K S L R K P F G D
390		 F M E P K F E F A V
400
K F N A L E L D D S
410		 D L A I F I A V I I
420		 L S G D R P G L L N
430		 V K P I E D I Q D N
440		 L L Q A L E L Q L K
450		 L N H P E S S Q L F
460		 A K L L Q K M T D L
470		 R Q I V T E H V Q L
480		 L Q V I K K T E T D
490		 M S L H P L L Q E I
500
Y K D L Y
505

Sequence annotations

Sequence annotation

The annotations you see in this panel are retrieved in real-time from several different sources using the Distributed Annotation System (DAS) protocol. This way you always have access to the most up-to-date information.

Annotations of the protein sequence are shown graphically. When you hover your mouse above one of the features, a little box that contains extra information appears.
If you want to know more about what a certain feature type means you can click on the feature types. This takes you to a page with information about what these features describe

SEQUENCE POSITIONAL FEATURES

Structure Elements

Structure elements

A protein structure consists of a sequence of structural elements (helices, loops). These elements are listed in this table.

For each element the 'local' residue numbering mapping is shown, and if available, the family numbers as well.
With local the residue numbers of this sequence are meant, starting at one and counting up.
Family numbers represent another type of numbering, where the numbers are valid for all proteins and independent of the residue numbers of individual protein sequences.

Structure elements

Snake plot

Snake plots

Snake plots (or resdiue-based diagrams) offer an intuitive way for looking at the sequence of a protein. In the plots, each residue in the transmembrane region is represented by a 'ball'. Those residues for which mutation data is available are clickable; when you hover your mouse over them, the pointer changes into the familiar 'hand/finger' icon. Clicking these residues takes you to a page with more information about the mutations found at that position.

view

Structures

Protein structures

Clicking on the '+' sign shows all available structures from the Protein DataBank (PDB) for this protein.

The PDB-id is shown, as well as the resolution of the structure and the (experimental) method with which the structure was obtained. You can sort the table by clicking the headers of the different columns.

Downloads

You can download the structure table by clicking the 'Download data' link. You will get a .txt file containing the information present in the table in 'tab-delimited' format.

PDBsum

The PDB-id is clickable, and clicking the link will take you to the PDBsum page of the structure. The PDBsum page contains a lot of information about the structure, such as detailed literature references and structure quality data. Also a number of visualization options are available.

Protein structures

Structure models

Protein structure models

Clicking on the '+' sign shows all available structure models for this protein.

The template PDB-id is shown, as well as a download link.

Protein structure models

Mutations

Mutations

Clicking on the '+' sign shows a table with all available mutations. You can browse through the multiple pages in the table by using the links in the top-right corner of the table.

Residue types

The 'Original' and 'Mutated' columns list the original and mutant amino acid types of the mutant.

Residue numbers

The 'Residue #' column lists the residue numbers of the mutants. The numbers are the 'local' residue numbers. The NucleaRDB residue numbers uniquely identify a residue position across multiple protein sequences. Using these 'global' numbers you can easily compare residues from different proteins.

Downloads

You can download the mutation table by clicking the 'Download all mutations' link. You will get a .txt file containing the information present in the table in 'tab-delimited' format.

Details

Clicking the 'details' link in the last column of the table takes you to a page that lists all available annotations of that mutation. These annotations can come from different sources and contain different types of data.

Mutation data