GPCRDB: Swiss-Prot entry
ID Q9MZU7_9CETA PRELIMINARY; PRT; 245 AA.
AC Q9MZU7;
DT 01-OCT-2000 (TrEMBLrel. 15, Created)
DT 01-OCT-2000 (TrEMBLrel. 15, Last sequence update)
DT 01-JUN-2003 (TrEMBLrel. 24, Last annotation update)
DE Prion protein precursor (Fragment).
GN Name=PrP;
OS Odocoileus virginianus (white-tailed deer).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Cetartiodactyla; Ruminantia; Pecora; Cervidae;
OC Odocoileinae; Odocoileus.
OX NCBI_TaxID=9874;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RX MEDLINE=20428412; PubMed=10970836 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1093/emboj/19.17.4425;
RA Raymond G.J., Bossers A., Raymond L.D., O'Rourke K.I., McHolland L.E.,
RA Bryant III P.K., Miller M.W., Williams E.S., Smits M., Caughey B.;
RT "Evidence of a molecular barrier limiting susceptibility of humans,
RT cattle and sheep to chronic wasting disease.";
RL EMBO J. 19:4425-4430(2000).
CC -!- SUBUNIT: PrP has a tendency to aggregate yielding polymers called
CC "rods" (By similarity).
CC -!- SUBCELLULAR LOCATION: Attached to the membrane by a GPI-anchor (By
CC similarity).
CC -!- SIMILARITY: Belongs to the prion family.
DR EMBL; AF156186; AAF80285.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR HSSP; P23907; 1G04. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR InterPro; IPR000817; Prion.
DR InterPro; Graphical view of domain structure.
DR Pfam; PF00377; Prion; 1.
DR Pfam; PF03991; Prion_octapep; 5.
DR Pfam; Graphical view of domain structure.
DR PRINTS; PR00341; PRION.
DR SMART; SM00157; PRP; 1.
DR PROSITE; PS00291; PRION_1; 1.
DR PROSITE; PS00706; PRION_2; 1.
DR HOVERGEN [Family / Alignment / Tree]
DR ProtoMap; Q9MZU7.
DR PRESAGE; Q9MZU7.
DR ModBase; Q9MZU7.
DR SMR; Q9MZU7.
DR SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW Prion; Repeat; Signal.
FT NON_TER 1 1
FT SIGNAL <1 13 Potential.
FT CHAIN 14 245 prion protein.
SQ SEQUENCE 245 AA; 26708 MW; 0D6E971C412ECA2E CRC64;
VLFVAMWSDV GLCKKRPKPG GGWNTGGSRY PGQGSPGGNR YPPQGGGGWG QPHGGGWGQP
HGGGWGQPHG GGWGQPHGGG GWGQGGTHSQ WNKPSKPKTN MKHVAGAAAA GAVVGGLGGY
MLGSAMNRPL IHFGNDYEDR YYRENMYRYP NQVYYRPVDQ YNNQNTFVHD CVNITVKQHT
VTTTTKGENF TETDIKMMER VVEQMCITQY QRESQAYYQR GASVILFSSP PVILLISFLI
FLIVG
//