GPCRDB: Swiss-Prot entry

ID   Q5UJH3_BOSJA PRELIMINARY;      PRT;   256 AA.
AC   Q5UJH3;
DT   01-FEB-2005 (TrEMBLrel. 29, Created)
DT   01-FEB-2005 (TrEMBLrel. 29, Last sequence update)
DT   01-FEB-2005 (TrEMBLrel. 29, Last annotation update)
DE   Prion protein.
GN   Name=PRNP;
OS   Bos javanicus (Wild banteng).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; 
OC   Mammalia; Eutheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; 
OC   Bovinae; Bos. 
OX   NCBI_TaxID=9906;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=TWBt2, and Bt478-2;
RX   PubMed=15477588 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1073/pnas.0406403101;
RA   Seabury C.M., Honeycutt R.L., Rooney A.P., Halbert N.D., Derr J.N.;
RT   "Prion protein gene (PRNP) variants and evidence for strong purifying
RT   selection in functionally important regions of bovine exon 3.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:15142-15147(2004).
CC   -!- FUNCTION: The function of PrP is not known. PrP is encoded in the
CC       host genome and is expressed both in normal and infected cells (By
CC       similarity).
CC   -!- SUBUNIT: PrP has a tendency to aggregate yielding polymers called
CC       "rods" (By similarity).
CC   -!- SUBCELLULAR LOCATION: Attached to the membrane by a GPI-anchor (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the prion family.
DR   EMBL; AY720694; AAV30501.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   EMBL; AY720692; AAV30499.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   GO; GO:0016020; C:membrane; IEA.
DR   InterPro; IPR000817; Prion.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF00377; Prion; 1.
DR   Pfam; PF03991; Prion_octapep; 5.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR00341; PRION.
DR   SMART; SM00157; PRP; 1.
DR   PROSITE; PS00291; PRION_1; 1.
DR   PROSITE; PS00706; PRION_2; 1.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain]
DR   HOVERGEN [Family / Alignment / Tree]
DR   ProtoMap; Q5UJH3.
DR   PRESAGE; Q5UJH3.
DR   ModBase; Q5UJH3.
DR   SMR; Q5UJH3.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   Membrane; Prion; Repeat.
SQ   SEQUENCE   256 AA;  27810 MW;  9420385D5DB7D60B CRC64;
     MVKSHIGSWI LVLFVAMWSD VGLCKKRPKP GGGWNTGGSR YPGQGSPGGN RYPPQGGGGW
     GQPHGGGWGQ PHGGGWGQPH GGGWGQPHGG GGWGQGGTHG QWNKPSKPKT NMKHVAGAAA
     AGAVVGGLGG YMLGSAMSRP LIHFGSDYED RYYRENMHRY PNQVYYRPVD QYSNQNSFVH
     DCVNITVKEH TVTTTTKGEN FTETDIKMME RVVEQMCITQ YQRESQAYYQ RGASVILFSS
     PPVILLISFL IFLIVG
//