Swiss-Prot entry

ID   PRIO_PAPHA     STANDARD;      PRT;   253 AA.
AC   P67996; P40254;
DT   01-FEB-1995 (Rel. 31, Created)
DT   01-FEB-1995 (Rel. 31, Last sequence update)
DT   10-MAY-2005 (Rel. 47, Last annotation update)
DE   Major prion protein precursor (PrP) (PrP27-30) (PrP33-35C).
GN   Name=PRNP; Synonyms=PRP;
OS   Papio hamadryas (Hamadryas baboon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; 
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini; 
OC   Cercopithecidae; Cercopithecinae; Papio. 
OX   NCBI_TaxID=9557;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=95139066; PubMed=7837269 [NCBI, ExPASy, EBI, Israel, Japan];
RA   Schaetzl H.M., Da Costa M., Taylor L., Cohen F.E., Prusiner S.B.;
RT   "Prion protein gene variation among primates.";
RL   J. Mol. Biol. 245:362-374(1995).
RN   [2]
RP   ERRATUM.
RX   PubMed=9020986 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1006/jmbi.1996.0791;
RA   Schaetzl H.M., Da Costa M., Taylor L., Cohen F.E., Prusiner S.B.;
RL   J. Mol. Biol. 265:257-257(1997).
CC   -!- FUNCTION: The function of PrP is not known. PrP is encoded in the
CC       host genome and is expressed both in normal and infected cells (By
CC       similarity).
CC   -!- SUBUNIT: PrP has a tendency to aggregate yielding polymers called
CC       "rods" (By similarity).
CC   -!- SUBCELLULAR LOCATION: Attached to the membrane by a GPI-anchor (By
CC       similarity).
CC   -!- DISEASE: PrP is found in high quantity in the brain of humans and
CC       animals infected with the degenerative neurological diseases kuru,
CC       Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome
CC       (GSS), scrapie, bovine spongiform encephalopathy (BSE),
CC       transmissible mink encephalopathy (TME), etc.
CC   -!- SIMILARITY: Belongs to the prion family.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; U08294; AAC50083.1; -; Genomic_DNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   HSSP; P23907; 1G04. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR   SMR; P67996; 119-226.
DR   InterPro; IPR000817; Prion.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF00377; Prion; 1.
DR   Pfam; PF03991; Prion_octapep; 5.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR00341; PRION.
DR   SMART; SM00157; PRP; 1.
DR   PROSITE; PS00291; PRION_1; 1.
DR   PROSITE; PS00706; PRION_2; 1.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain]
DR   HOVERGEN [Family / Alignment / Tree]
DR   BLOCKS; P67996.
DR   ProtoNet; P67996.
DR   ProtoMap; P67996.
DR   PRESAGE; P67996.
DR   DIP; P67996.
DR   ModBase; P67996.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   Glycoprotein; GPI-anchor; Lipoprotein; Membrane; Prion; Repeat;
KW   Signal.
FT   SIGNAL        1     22       By similarity.
FT   CHAIN        23    230       Major prion protein.
FT   PROPEP      231    253       Removed in mature form (By similarity).
FT   REPEAT       51     59       1.
FT   REPEAT       60     67       2.
FT   REPEAT       68     75       3.
FT   REPEAT       76     83       4.
FT   REPEAT       84     91       5.
FT   REGION       51     91       5 X 8 AA tandem repeats of P-H-G-G-G-W-G-
FT                                Q.
FT   LIPID       230    230       GPI-anchor amidated serine (By
FT                                similarity).
FT   CARBOHYD    181    181       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    197    197       N-linked (GlcNAc...) (Potential).
FT   DISULFID    179    214       By similarity.
SQ   SEQUENCE   253 AA;  27676 MW;  F01D5EA64AB68C31 CRC64;
     MANLGCWMLV LFVATWSDLG LCKKRPKPGG WNTGGSRYPG QGSPGGNRYP PQGGGGWGQP
     HGGGWGQPHG GGWGQPHGGG WGQPHGGGWG QGGGTHNQWH KPSKPKTSMK HMAGAAAAGA
     VVGGLGGYML GSAMSRPLIH FGNDYEDRYY RENMYRYPNQ VYYRPVDQYS NQNNFVHDCV
     NITIKQHTVT TTTKGENFTE TDVKMMERVV EQMCITQYEK ESQAYYQRGS SMVLFSSPPV
     ILLISFLIFL IVG
//