Swiss-Prot entry

ID   PRIO_OVICA     STANDARD;      PRT;   256 AA.
AC   Q7JIH3;
DT   25-OCT-2004 (Rel. 45, Created)
DT   25-OCT-2004 (Rel. 45, Last sequence update)
DT   10-MAY-2005 (Rel. 47, Last annotation update)
DE   Major prion protein precursor (PrP).
GN   Name=PRNP; Synonyms=PRP;
OS   Ovis canadensis (Bighorn sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; 
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; 
OC   Pecora; Bovidae; Caprinae; Ovis. 
OX   NCBI_TaxID=37174;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain;
RA   O'Rourke K.I., Spraker T.R., Wild M.A., Miller M.W.;
RT   "PrP gene sequence for big horn sheep (Ovis canadensis).";
RL   Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The function of PrP is not known. PrP is encoded in the
CC       host genome and is expressed both in normal and infected cells (By
CC       similarity).
CC   -!- SUBUNIT: PrP has a tendency to aggregate yielding polymers called
CC       "rods" (By similarity).
CC   -!- SUBCELLULAR LOCATION: Attached to the membrane by a GPI-anchor (By
CC       similarity).
CC   -!- DISEASE: Found in high quantity in the brain of humans and animals
CC       infected with degenerative neurological diseases such as kuru,
CC       Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome
CC       (GSS), scrapie, bovine spongiform encephalopathy (BSE),
CC       transmissible mink encephalopathy (TME), etc.
CC   -!- SIMILARITY: Belongs to the prion family.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; AF166334; AAD48030.1; -; Genomic_DNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   SMR; Q7JIH3; 128-233.
DR   InterPro; IPR000817; Prion.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF00377; Prion; 1.
DR   Pfam; PF03991; Prion_octapep; 5.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR00341; PRION.
DR   SMART; SM00157; PRP; 1.
DR   PROSITE; PS00291; PRION_1; 1.
DR   PROSITE; PS00706; PRION_2; 1.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain]
DR   HOVERGEN [Family / Alignment / Tree]
DR   BLOCKS; Q7JIH3.
DR   ProtoNet; Q7JIH3.
DR   ProtoMap; Q7JIH3.
DR   PRESAGE; Q7JIH3.
DR   DIP; Q7JIH3.
DR   ModBase; Q7JIH3.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   Glycoprotein; GPI-anchor; Lipoprotein; Membrane; Prion; Repeat;
KW   Signal.
FT   SIGNAL        1     24       By similarity.
FT   CHAIN        25    233       Major prion protein.
FT   PROPEP      234    256       Removed in mature form (Potential).
FT   REPEAT       54     62       1.
FT   REPEAT       63     70       2.
FT   REPEAT       71     78       3.
FT   REPEAT       79     86       4.
FT   REPEAT       87     95       5.
FT   REGION       54     95       5 X 8 AA tandem repeats of P-H-G-G-G-W-G-
FT                                Q.
FT   LIPID       233    233       GPI-anchor amidated alanine (Potential).
FT   CARBOHYD    184    184       N-linked (GlcNAc...) (Probable).
FT   CARBOHYD    200    200       N-linked (GlcNAc...) (Probable).
FT   DISULFID    182    217       By similarity.
SQ   SEQUENCE   256 AA;  27887 MW;  BFC8E95F6FD99746 CRC64;
     MVKSHIGSWI LVLFVAMWSD VGLCKKRPKP GGGWNTGGSR YPGQGSPGGN RYPPQGGGGW
     GQPHGGGWGQ PHGGGWGQPH GGGWGQPHGG GGWGQGGSHS QWNKPSKPKT NMKHVAGAAA
     AGAVVGGLGG YMLGSAMSRP LIHFGNDYED RYYRENMYRY PNQVYYRPVD QYSNQNNFVH
     DCVNITVKQH TVTTTTKGEN FTETDIKIME RVVEQMCITQ YQRESQAYYQ RGASVILFSS
     PPVILLISFL IFLIVG
//