GPCRDB: Swiss-Prot entry

ID   PRIO_ATEPA     STANDARD;      PRT;   252 AA.
AC   P51446;
DT   01-OCT-1996 (Rel. 34, Created)
DT   01-OCT-1996 (Rel. 34, Last sequence update)
DT   05-JUL-2004 (Rel. 44, Last annotation update)
DE   Major prion protein precursor (PrP) (PrP27-30) (PrP33-35C).
GN   Name=PRNP;
OS   Ateles paniscus (Black spider monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; 
OC   Mammalia; Eutheria; Primates; Platyrrhini; Cebidae; Atelinae; Ateles. 
OX   NCBI_TaxID=9510;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain;
RX   MEDLINE=95083661; PubMed=7991600 [NCBI, ExPASy, EBI, Israel, Japan];
RA   Cervenakova L., Brown P., Goldfarb L.G., Nagle J., Pettrone K.,
RA   Rubenstein R., Dubnick M., Gibbs C.J., Gajdusek D.C.;
RT   "Infectious amyloid precursor gene sequences in primates used for
RT   experimental transmission of human spongiform encephalopathy.";
RL   Proc. Natl. Acad. Sci. U.S.A. 91:12159-12162(1994).
CC   -!- FUNCTION: The function of PrP is not known. PrP is encoded in the
CC       host genome and is expressed both in normal and infected cells.
CC   -!- SUBUNIT: PrP has a tendency to aggregate yielding polymers called
CC       "rods".
CC   -!- SUBCELLULAR LOCATION: Attached to the membrane by a GPI-anchor.
CC   -!- DISEASE: PrP is found in high quantity in the brain of humans and
CC       animals infected with the degenerative neurological diseases kuru,
CC       Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome
CC       (GSS), scrapie, bovine spongiform encephalopathy (BSE),
CC       transmissible mink encephalopathy (TME), etc.
CC   -!- SIMILARITY: Belongs to the prion family.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; U15164; AAA68634.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   HSSP; P23907; 1G04. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR   InterPro; IPR000817; Prion.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF00377; Prion; 1.
DR   Pfam; PF03991; Prion_octapep; 6.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR00341; PRION.
DR   PROSITE; PS00291; PRION_1; 1.
DR   PROSITE; PS00706; PRION_2; 1.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain]
DR   HOVERGEN [Family / Alignment / Tree]
DR   BLOCKS; P51446.
DR   ProtoNet; P51446.
DR   ProtoMap; P51446.
DR   PRESAGE; P51446.
DR   DIP; P51446.
DR   ModBase; P51446.
DR   SMR; P51446.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   Glycoprotein; GPI-anchor; Lipoprotein; Prion; Repeat; Signal.
FT   SIGNAL        1     22       By similarity.
FT   CHAIN        23    229       Major prion protein.
FT   PROPEP      230    252       Removed in mature form (By similarity).
FT   LIPID       229    229       GPI-anchor amidated serine (By
FT                                similarity).
FT   DISULFID    178    213       By similarity.
FT   CARBOHYD    180    180       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    196    196       N-linked (GlcNAc...) (Potential).
FT   DOMAIN       51     90       5 X 8 AA tandem repeats of P-H-G-G-G-W-G-
FT                                Q.
FT   REPEAT       51     58       1.
FT   REPEAT       59     66       2.
FT   REPEAT       67     74       3.
FT   REPEAT       75     82       4.
FT   REPEAT       83     90       5.
SQ   SEQUENCE   252 AA;  27718 MW;  20EA38A42DCC56D1 CRC64;
     MANLGYWMLV LFVATWSDLG LCKKRPKPGG WNTGGSRYPG QGSPGGNRYP PQGGGWGQPH
     GGGWGQPHGG GWGQPHGGGW GQPHGGGWGQ AGGTHNQWNK PSKPKTNMKH MAGAAAAGAV
     VGGLGGYMLG SAMSRPLIHF GNDYEDRYYR ENMYRYPNQV YYRPVDQYNN QNNFVHDCVN
     ITIKQHTVTT TTKGENLTET DVKMMERVVE QMCITQYERE SQAYYQRGSS MVLFSSPPVI
     LLISFLIFLI VG
//