PrionDB Prion-like protein doppel precursor (PrPLP) - Mutation data

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This multiple sequence alignment displays point mutations extracted from the literature.
The top layer shows the consensus sequence and the putative location of structural and functional domains. Residues with available mutation data are hyperlinked to pages that display information on the point mutants. Those positions are marked by a '!' on the right of the alignment.The 'name' of the mutant is displayed in the bottom bar of your browser when you pass the mouse over a hyperlinked position.



                                                                                                                                                                                                        

                                                                                                                                                                                                        
CONSENSUS          MRKHLGGCWLAIVCMLLFSHLSSVKARGIKHRIKWNRKVLPSTSQITEARTAEIRPGAFIKQGRKLDIDFGAEGNRYYEA                                                                                                     
PRND_BOVIN         MRKHLGGCWLAIVCILLFSQLCSVKARGIKHRIKWNRKVLPSTSQVTEARTAEIRPGAFIKQGRKLDIDFGVEGNRYYEA
PRND_SHEEP         MRKHLGGCWLAIVCVLLFSQLSSVKARGIKHRIKWNRKVLPSTSQVTEAHTAEIRPGAFIKQGRKLDINFGVEGNRYYEA
PRND_HUMAN         MRKHLSWWWLATVCMLLFSHLSAVQTRGIKHRIKWNRKALPSTAQITEAQVAENRPGAFIKQGRKLDIDFGAEGNRYYEA  !  
PRND_MOUSE         MKNRLGTWWVAILCMLLASHLSTVKARGIKHRFKWNRKVLPsgGQITEARVAENRPGAFIKQGRKLDIDFGAEGNRYYAA

                                                                                                                                                                                                        

                                                                                                                                                                                                        
CONSENSUS          NYWQFPDGIHYNGCSEANVTKEKFVTSCINATQAANQEEFEKQDNKLHQRVLWQLIRELCSAKHCDFWLERGAGLRVTLD                                                                                                     
PRND_BOVIN         NYWQFPDGIHYNGCSKANVTKEKFITSCINATQAANQEerEKQDNKLYQRVLWQLIRELCSTKHCDFWLERGAGLRVTLD
PRND_SHEEP         NYWQFPDGIHYNGCSEANVTKEKFVTSCINATQVANQEerEKQDNKLYQRVLWQLIRELCSIKHCDFWLERGAGLQVTLD
PRND_HUMAN         NYWQFPDGIHYNGCSEANVTKEAFVTGCINATQAANQGEFQKPDNKLHQQVLWRLVQELCSLKHCEFWLERGAGLRVTMH  !  
PRND_MOUSE         NYWQFPDGIYYEGCSEANVTKEMLVTSCVNATQAANQAEfeKQDSKLHQRVLWRLIKEICSAKHCDFWLERGAALRVAVD  !  

                                                                                                                                                                                                        

                                                                                                                                                                                                        
CONSENSUS          QPMMLCLLVFIWFIVK                                                                                                                                                                     
PRND_BOVIN         QPMMLCLLVFIWFIVK................................................................
PRND_SHEEP         QPMMLCLLVFIWFIVK................................................................
PRND_HUMAN         QPVLLCLLALIWLMVK................................................................
PRND_MOUSE         QPAMVCLLGFVWFIVK................................................................


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