PrionDB: Extraction of mutation data from the literature

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This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes different point mutations at a given position and provides links to other documents. The sentence(s) where the point mutations in PRIO_MOUSE at position 112 were found are listed after the table.

Point mutations at position A112 in PRIO_MOUSE

ProteinPRIO_MOUSE (P04925)    Gene: Prnp,Prn-p    (other point mutations)Swiss-Prot
Cross-reference table
Family page
PositionA112
General numbering (PrionDB) -
DomainNot determined
Family alignments Mammalian prion proteins
Prion proteins (PRP, PRNP)
Other point mutations at the same position Position 113 in Mammalian prion proteins family
Position 113 in Prion proteins (PRP, PRNP) family
Reference #1Stewart RS, Drisaldi B, Harris DA
Mol Biol Cell 2001 Apr;12(4):881-9.		Medline
Text sourceHTML full text
Point mutationA112V (True positive)
Reference #2Stewart RS, Harris DA
J Biol Chem 2005 Apr 22;280(16):15855-64. Epub 2005 Jan 25.		Medline
Text sourceHTML full text
Point mutationA112V (True positive)

Relevant sentences

Reference #1 (Stewart RS et al.): A112V
  • As reported previously (Hegde et al. , 1998a(image) , 1999(image) ) , the presence of either of two mutations (A116V or A112V / A114V / A117V , referred to as 3AV) in the transmembrane domain significantly increased the proportion of CtmPrP (lanes 5 and 8)

Reference #2 (Stewart RS et al.): A112V
  • 3AV is the designation for the triple mutation A112V / A114V / A117V

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F.Horn (priondbcmbi.ru.nl), 22-Aug-2005