PrionDB: Point mutations extracted from the literature - PRIO_MOUSE

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This data was extracted from medline abstracts and full text papers (when available) in an automated manner.

Each point mutation is linked to the entry specific to the residue position. Citations are linked to the list of point mutations found in the corresponding articles. The last column allows you to go back to the original text via Medline.

ProteinPRIO_MOUSE (Prnp,Prn-p)Swiss-Prot
Cross-reference table
Family page
Family alignments Mammalian prion proteins
Prion proteins (PRP, PRNP)

MutationLocationGeneral numberingReference
L9DNot determined Stewart RS et al., J Biol Chem 2003Medline
L9GNot determined Stewart RS et al., J Biol Chem 2003Medline
L9KNot determined Stewart RS et al., J Biol Chem 2003Medline
L9PNot determined Stewart RS et al., J Biol Chem 2003Medline
L9RNot determined Stewart RS et al., J Biol Chem 2003Medline
L9RNot determined Drisaldi B et al., J Biol Chem 2003Medline
L9RNot determined Stewart RS et al., Mol Biol Cell 2001Medline
L9RNot determined Stewart RS et al., J Biol Chem 2005Medline
V13DNot determined Stewart RS et al., J Biol Chem 2003Medline
V13RNot determined Stewart RS et al., J Biol Chem 2003Medline
G20WNot determined Stewart RS et al., J Biol Chem 2003Medline
C22YNot determined Stewart RS et al., J Biol Chem 2003Medline
Q52HNot determined Sakudo A et al., Biochem Biophys Res Commun 2003Medline
G57SNot determined Friberg MA et al., J Biol Chem 2004Medline
P101LNot determined Liemann S et al., Biochemistry 1999Medline
P101LNot determined Chiesa R et al., Proc Natl Acad Sci U S A 2000Medline
P101LNot determined Turnbull S et al., Biochemistry 2003Medline
P101LNot determined Manson JC et al., Arch Virol Suppl 2000Medline
P101LNot determined Mishra RS et al., J Biol Chem 2002Medline
P101LNot determined Barron RM et al., EMBO J 2001Medline
P101LNot determined Mastrangelo P et al., Gene 2001Medline
P101LNot determined Laws DD et al., Proc Natl Acad Sci U S A 2001Medline
P101LNot determined Telling GC et al., Genes Dev 1996Medline
P101LNot determined Shmerling D et al., Cell 1998Medline
P101LNot determined Chiesa R et al., Neuron 1998Medline
P101LNot determined Flechsig E et al., Neuron 2000Medline
P101LNot determined Nixon R et al., J Biol Chem 2005Medline
P101LNot determined Barron RM et al., Clin Lab Med 2003Medline
P101LNot determined Weissmann C et al., Br Med Bull 2003Medline
P101LNot determined Harris D et al., Br Med Bull 2003Medline
P101LNot determined Inouye H et al., J Mol Biol 2000Medline
P101LNot determined Barron RM et al., J Gen Virol 2003Medline
P101LNot determined Cappai R et al., Biochemistry 1999Medline
P101LNot determined Stewart RS et al., J Biol Chem 2005Medline
P101LNot determined Li A et al., J Biol Chem 2005Medline
P101LNot determined Mallucci GR et al., Brain 1999Medline
P101LNot determined Stewart RS et al., J Biol Chem 2001Medline
P101LNot determined Tagliavini F et al., J Biol Chem 2001Medline
P101LNot determined Alonso DO et al., Proc Natl Acad Sci U S A 2001Medline
P101LNot determined Ivanova L et al., J Biol Chem 2001Medline
P101LNot determined Lorenz H et al., J Biol Chem 2002Medline
P101LNot determined Wegner C et al., J Gen Virol 2002Medline
P101LNot determined Gauczynski S et al., J Cell Sci 2002Medline
P101LNot determined Cohen E et al., EMBO J 2003Medline
P101LNot determined Tremblay P et al., J Virol 2004Medline
P104LNot determined Cohen E et al., EMBO J 2003Medline
N107INot determined Stewart RS et al., Mol Biol Cell 2001Medline
N107INot determined Stewart RS et al., J Biol Chem 2001Medline
L108FNot determined Liemann S et al., Biochemistry 1999Medline
L108FNot determined Mastrangelo P et al., Gene 2001Medline
L108FNot determined Tremblay P et al., J Virol 2004Medline
L108FNot determined Manson JC et al., EMBO J 1999Medline
L108MNot determined Heller U et al., J Biol Chem 2003Medline
L108MNot determined Atarashi R et al., J Biol Chem 2003Medline
L108MNot determined Walmsley AR et al., EMBO J 2001Medline
L108MNot determined Holscher C et al., J Biol Chem 2001Medline
L108MNot determined Heske J et al., J Biol Chem 2004Medline
K109INot determined Stewart RS et al., J Biol Chem 2003Medline
K109INot determined Stewart RS et al., Mol Biol Cell 2001Medline
K109INot determined Stewart RS et al., J Biol Chem 2001Medline
K109INot determined Stewart RS et al., J Biol Chem 2005Medline
H110INot determined Stewart RS et al., J Biol Chem 2003Medline
H110INot determined Stewart RS et al., Mol Biol Cell 2001Medline
H110INot determined Stewart RS et al., J Biol Chem 2001Medline
H110INot determined Stewart RS et al., J Biol Chem 2005Medline
V111MNot determined Heller U et al., J Biol Chem 2003Medline
V111MNot determined Atarashi R et al., J Biol Chem 2003Medline
V111MNot determined Walmsley AR et al., EMBO J 2001Medline
V111MNot determined Uelhoff A et al., J Biol Chem 2005Medline
V111MNot determined Holscher C et al., J Biol Chem 2001Medline
V111MNot determined Kiachopoulos S et al., J Biol Chem 2005Medline
V111MNot determined Narwa R et al., Biochemistry 1999Medline
V111MNot determined Heske J et al., J Biol Chem 2004Medline
A112VNot determined Stewart RS et al., Mol Biol Cell 2001Medline
A112VNot determined Stewart RS et al., J Biol Chem 2005Medline
A114VNot determined Stewart RS et al., Mol Biol Cell 2001Medline
A114VNot determined Stewart RS et al., J Biol Chem 2005Medline
A116VNot determined Stewart RS et al., J Biol Chem 2003Medline
A116VNot determined Stewart RS et al., Mol Biol Cell 2001Medline
A116VNot determined Stewart RS et al., J Biol Chem 2001Medline
A117VNot determined Stewart RS et al., J Biol Chem 2003Medline
A117VNot determined Heller U et al., J Biol Chem 2003Medline
A117VNot determined Kim SJ et al., J Biol Chem 2001Medline
A117VNot determined Stewart RS et al., Mol Biol Cell 2001Medline
A117VNot determined Uelhoff A et al., J Biol Chem 2005Medline
A117VNot determined Stewart RS et al., J Biol Chem 2001Medline
A117VNot determined Narwa R et al., Biochemistry 1999Medline
A117VNot determined Heske J et al., J Biol Chem 2004Medline
A117VNot determined Tremblay P et al., J Virol 2004Medline
A117VNot determined Muramoto T et al., Proc Natl Acad Sci U S A 1996Medline
A117VNot determined Stewart RS et al., J Biol Chem 2005Medline
G122PNot determined Stewart RS et al., J Biol Chem 2003Medline
G122PNot determined Heller U et al., J Biol Chem 2003Medline
G122PNot determined Stewart RS et al., Mol Biol Cell 2001Medline
G122PNot determined Stewart RS et al., J Biol Chem 2001Medline
Y127Not determined Perera WS et al., FEBS Lett 1999Medline
M128VNot determined Liemann S et al., Biochemistry 1999Medline
M128VNot determined Harris D et al., Br Med Bull 2003Medline
M128VNot determined Ivanova L et al., J Biol Chem 2001Medline
I138MNot determined Atarashi R et al., J Biol Chem 2003Medline
I138MNot determined Muramoto T et al., Proc Natl Acad Sci U S A 1996Medline
W144XNot determined Lorenz H et al., J Biol Chem 2002Medline
Y154NNot determined Atarashi R et al., J Biol Chem 2003Medline
Q159XNot determined Lorenz H et al., J Biol Chem 2002Medline
V160SNot determined Kiachopoulos S et al., J Biol Chem 2005Medline
V160WNot determined Kiachopoulos S et al., J Biol Chem 2005Medline
Q167ENot determined Kaneko K et al., Proc Natl Acad Sci U S A 1997Medline
Q167RNot determined Perrier V et al., Proc Natl Acad Sci U S A 2002Medline
Q167RNot determined Crozet C et al., J Cell Sci 2004Medline
Q167RNot determined Kaneko K et al., Proc Natl Acad Sci U S A 1997Medline
S169NNot determined Atarashi R et al., J Biol Chem 2003Medline
Q171RNot determined Zulianello L et al., J Virol 2000Medline
Q171RNot determined Mastrangelo P et al., Gene 2001Medline
Q171RNot determined Kaneko K et al., Proc Natl Acad Sci U S A 1997Medline
H176Not determined Perera WS et al., FEBS Lett 1999Medline
D177NNot determined Liemann S et al., Biochemistry 1999Medline
D177NNot determined Drisaldi B et al., J Biol Chem 2003Medline
D177NNot determined Fioriti L et al., J Biol Chem 2005Medline
D177NNot determined Ma J et al., Proc Natl Acad Sci U S A 2001Medline
D177NNot determined Gsponer J et al., J Mol Graph Model 2001Medline
D177NNot determined Levy Y et al., Proteins 2002Medline
D177NNot determined Turnbull S et al., Biochemistry 2003Medline
D177NNot determined Stewart RS et al., J Biol Chem 2001Medline
D177NNot determined Wong NK et al., J Mol Graph Model 2000Medline
D177NNot determined Harris D et al., Br Med Bull 2003Medline
D177NNot determined Narwa R et al., Biochemistry 1999Medline
D177NNot determined Li A et al., J Biol Chem 2005Medline
D177NNot determined Ivanova L et al., J Biol Chem 2001Medline
D177NNot determined Lorenz H et al., J Biol Chem 2002Medline
D177NNot determined Wegner C et al., J Gen Virol 2002Medline
D177NNot determined Gauczynski S et al., J Cell Sci 2002Medline
C178ANot determined Yanai A et al., FEBS Lett 1999Medline
C178ANot determined Muramoto T et al., Proc Natl Acad Sci U S A 1996Medline
V179INot determined Liemann S et al., Biochemistry 1999Medline
V179INot determined Stewart RS et al., J Biol Chem 2001Medline
N180QNot determined Kiachopoulos S et al., J Biol Chem 2005Medline
N180QNot determined Neuendorf E et al., J Biol Chem 2004Medline
N180SNot determined Heller U et al., J Biol Chem 2003Medline
T182ANot determined Liemann S et al., Biochemistry 1999Medline
T182ANot determined Korth C et al., J Gen Virol 2000Medline
T182ANot determined Drisaldi B et al., J Biol Chem 2003Medline
T182ANot determined Wong NK et al., J Mol Graph Model 2000Medline
T182ANot determined Kiachopoulos S et al., J Biol Chem 2005Medline
T182ANot determined Neuendorf E et al., J Biol Chem 2004Medline
T182ANot determined Lehmann S et al., J Biol Chem 1997Medline
T182NNot determined Neuendorf E et al., J Biol Chem 2004Medline
T182SNot determined Neuendorf E et al., J Biol Chem 2004Medline
T182XNot determined Neuendorf E et al., J Biol Chem 2004Medline
T187KNot determined Lorenz H et al., J Biol Chem 2002Medline
T187RNot determined Lorenz H et al., J Biol Chem 2002Medline
T189VNot determined Liemann S et al., Biochemistry 1999Medline
T189VNot determined Mastrangelo P et al., Gene 2001Medline
T189VNot determined Tremblay P et al., J Virol 2004Medline
T189VNot determined Manson JC et al., EMBO J 1999Medline
N196QNot determined Korth C et al., J Gen Virol 2000Medline
N196QNot determined Kiachopoulos S et al., J Biol Chem 2005Medline
N196QNot determined Neuendorf E et al., J Biol Chem 2004Medline
N196SNot determined Heller U et al., J Biol Chem 2003Medline
F197Not determined Iovino M et al., J Biomol Struct Dyn 2001Medline
F197SNot determined Liemann S et al., Biochemistry 1999Medline
F197SNot determined Turnbull S et al., Biochemistry 2003Medline
F197SNot determined Kiachopoulos S et al., J Biol Chem 2005Medline
F197SNot determined Stewart RS et al., J Biol Chem 2001Medline
F197SNot determined Wong NK et al., J Mol Graph Model 2000Medline
F197SNot determined Harris D et al., Br Med Bull 2003Medline
F197SNot determined Li A et al., J Biol Chem 2005Medline
F197SNot determined Ivanova L et al., J Biol Chem 2001Medline
T198Not determined Iovino M et al., J Biomol Struct Dyn 2001Medline
T198ANot determined Korth C et al., J Gen Virol 2000Medline
T198ANot determined Drisaldi B et al., J Biol Chem 2003Medline
T198ANot determined Wong NK et al., J Mol Graph Model 2000Medline
T198ANot determined Neuendorf E et al., J Biol Chem 2004Medline
T198ANot determined Lehmann S et al., J Biol Chem 1997Medline
T198NNot determined Neuendorf E et al., J Biol Chem 2004Medline
E199KNot determined Liemann S et al., Biochemistry 1999Medline
E199KNot determined Yanai A et al., FEBS Lett 1999Medline
E199KNot determined Atarashi R et al., J Biol Chem 2003Medline
E199KNot determined Levy Y et al., Proteins 2002Medline
E199KNot determined Turnbull S et al., Biochemistry 2003Medline
E199KNot determined Daude N et al., J Biol Chem 1997Medline
E199KNot determined Supattapone S et al., J Virol 2000Medline
E199KNot determined Stewart RS et al., J Biol Chem 2001Medline
E199KNot determined Wong NK et al., J Mol Graph Model 2000Medline
E199KNot determined Narwa R et al., Biochemistry 1999Medline
E199KNot determined Li A et al., J Biol Chem 2005Medline
E199KNot determined Ivanova L et al., J Biol Chem 2001Medline
E199KNot determined Lorenz H et al., J Biol Chem 2002Medline
E199KNot determined Wegner C et al., J Gen Virol 2002Medline
E199KNot determined Gauczynski S et al., J Cell Sci 2002Medline
E199KNot determined Weissmann C et al., Br Med Bull 2003Medline
D201Not determined Iovino M et al., J Biomol Struct Dyn 2001Medline
V202Not determined Iovino M et al., J Biomol Struct Dyn 2001Medline
M204SNot determined Kiachopoulos S et al., J Biol Chem 2005Medline
R207HNot determined Liemann S et al., Biochemistry 1999Medline
V209INot determined Liemann S et al., Biochemistry 1999Medline
V209INot determined Stewart RS et al., J Biol Chem 2001Medline
C213ANot determined Supattapone S et al., J Virol 2000Medline
V214DNot determined Kaneko K et al., Proc Natl Acad Sci U S A 1997Medline
V214INot determined Zulianello L et al., J Virol 2000Medline
Q216RNot determined Liemann S et al., Biochemistry 1999Medline
Q216RNot determined Wong NK et al., J Mol Graph Model 2000Medline
Q218KNot determined Zulianello L et al., J Virol 2000Medline
Q218KNot determined Perrier V et al., Proc Natl Acad Sci U S A 2002Medline
Q218KNot determined Ryou C et al., J Mol Biol 2003Medline
Q218KNot determined Crozet C et al., J Cell Sci 2004Medline

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F.Horn (priondbcmbi.ru.nl), 22-Aug-2005