PrionDB: Extraction of mutation data from the literature

2005, PrionDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation A113V was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation A113V in PRIO_HUMAN

Point mutation:	A113V
Domain:	Not determined
General numbering (PrionDB):	-
Protein:	PRIO_HUMAN (PRNP)	Swiss-Prot Cross-reference table Family page
Other point mutations / same protein	List of mutations in PRIO_HUMAN
Family alignments	Mammalian prion proteins Prion proteins (PRP, PRNP)
Other point mutations / same position	Position 113 in Mammalian prion proteins family Position 113 in Prion proteins (PRP, PRNP) family
Reference:	Prions. Prusiner SB Proc Natl Acad Sci U S A 1998 Nov 10;95(23):13363-83.	Medline
Other point mutations / same article	List
Text source	HTML full text
Validation status	True positive

Relevant sentences:

A113V

An artificial set of mutations in a PrP transgene consisting of A113V , A115V , and A118V produced neurodegeneration in neonatal mice ; these Val substitutions were selected for their propensity to form beta -sheets (153 , 251 )

F.Horn (priondbcmbi.ru.nl), 22-Aug-2005