PrionDB: Extraction of mutation data from the literature

2005, PrionDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation D147N was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation D147N in PRIO_HUMAN

Point mutation:	D147N
Domain:	Not determined
General numbering (PrionDB):	-
Protein:	PRIO_HUMAN (PRNP)	Swiss-Prot Cross-reference table Family page
Other point mutations / same protein	List of mutations in PRIO_HUMAN
Family alignments	Mammalian prion proteins Prion proteins (PRP, PRNP)
Other point mutations / same position	Position 147 in Mammalian prion proteins family Position 147 in Prion proteins (PRP, PRNP) family
Reference:	The role of electrostatic interaction in triggering the unraveling of stable helix 1 in normal prion protein. A molecular dynamics simulation investigation. Ji HF, Zhang HY, Shen L J Biomol Struct Dyn 2005 Apr;22(5):563-70.	Medline
Other point mutations / same article	List
Text source	abstract
Validation status	Not yet checked

Relevant sentences:

D147N

This explanation is supported by experimental evaluation and MD simulation on D147N mutant of HuPrPC that the mutant becomes a little more stable than the wild type HuPrPC

F.Horn (priondbcmbi.ru.nl), 22-Aug-2005