PrionDB: Extraction of mutation data from the literature

2005, PrionDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation V111M was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation V111M in PRIO_MOUSE

Point mutation:	V111M
Domain:	Not determined
General numbering (PrionDB):	-
Protein:	PRIO_MOUSE (Prnp,Prn-p)	Swiss-Prot Cross-reference table Family page
Other point mutations / same protein / same position	Point mutations at position 111 in PRIO_MOUSE
Other point mutations / same protein	List of mutations in PRIO_MOUSE
Family alignments	Mammalian prion proteins Prion proteins (PRP, PRNP)
Other point mutations / same position	Position 112 in Mammalian prion proteins family Position 112 in Prion proteins (PRP, PRNP) family
Reference:	A pathogenic PrP mutation and doppel interfere with polarized sorting of the prion protein. Uelhoff A, Tatzelt J, Aguzzi A, Winklhofer KF, Haass C J Biol Chem 2005 Feb 18;280(7):5137-40. Epub 2004 Dec 21.	Medline
Other point mutations / same article	List
Text source	HTML full text
Validation status	Not yet checked

Relevant sentences:

V111M

EXPERIMENTAL PROCEDURES (image)TOP (image)ABSTRACT (image)INTRODUCTION (image)EXPERIMENTAL PROCEDURES (image)RESULTS (image)DISCUSSION (image)REFERENCES cDNA Constructs—The coding region of mouse PRNP modified to express PrP-L108M / V111M was inserted into the pcDNA3.1 / Zeo vector (Invitrogen ) , allowing detection by the 3F4 monoclonal antibody (24 )

F.Horn (priondbcmbi.ru.nl), 22-Aug-2005