PrionDB: Extraction of mutation data from the literature

2005, PrionDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation V136A was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation V136A in PRND_HUMAN

Point mutation:	V136A
Domain:	Not determined
General numbering (PrionDB):	-
Protein:	PRND_HUMAN (PRND,DPL)	Swiss-Prot Cross-reference table Family page
Other point mutations / same protein	List of mutations in PRND_HUMAN
Family alignments	Prion-like protein doppel precursor (PrPLP)
Other point mutations / same position
Reference:	Insight into the PrPC-->PrPSc conversion from the structures of antibody-bound ovine prion scrapie-susceptibility variants. Eghiaian F, Grosclaude J, Lesceu S, Debey P, Doublet B, Treguer E, Rezaei H, Knossow M Proc Natl Acad Sci U S A 2004 Jul 13;101(28):10254-9. Epub 2004 Jul 6.	Medline
Other point mutations / same article	List
Text source	HTML full text
Validation status	Not yet checked

Relevant sentences:

V136A

Indeed , it was shown recently that ovine (Ov)PrP mutations V136A and Q171R , associated with a resistant phenotype in sheep , destabilize the recombinant prion protein (8 )
Structural comparisons of OvPrP variants ARR , ARQ , and VRQ show that mutations V136A and Q171R lead to disruption of hydrogen bonds located at the surface of the ovine recombinant prion protein

F.Horn (priondbcmbi.ru.nl), 22-Aug-2005