PrionDB: Extraction of mutation data from the literature

2005, PrionDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation T183A was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation T183A in PRIO_HUMAN

Point mutation:	T183A
Domain:	Not determined
General numbering (PrionDB):	-
Protein:	PRIO_HUMAN (PRNP)	Swiss-Prot Cross-reference table Family page
Other point mutations / same protein / same position	Point mutations at position 183 in PRIO_HUMAN
Other point mutations / same protein	List of mutations in PRIO_HUMAN
Family alignments	Mammalian prion proteins Prion proteins (PRP, PRNP)
Other point mutations / same position	Position 183 in Mammalian prion proteins family Position 183 in Prion proteins (PRP, PRNP) family
Reference:	Sporadic and familial CJD: classification and characterisation. Gambetti P, Kong Q, Zou W, Parchi P, Chen SG Br Med Bull 2003;66:213-39.	Medline
Other point mutations / same article	List
Text source	HTML full text
Validation status	True positive

Relevant sentences:

T183A

The T183A-129M haplotype (CJD T183A-129M) This has been observed in 17 subjects , of whom 12 were from a Brazilian kindred of Spanish and Italian origin and the others from the US , Germany , and Venezuela52
Cardozo J , Caruso G , Molina O et al. Familial transmissible spongiform encephalopathy with the T183A mutation on the prion protein gene (PRNP)
First North American report of the T183A mutation in the prion protein gene: clinical , pathological , and biochemical analysis of one case

F.Horn (priondbcmbi.ru.nl), 22-Aug-2005