PrionDB: Extraction of mutation data from the literature

2005, PrionDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation M205V was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation M205V in PRIO_HUMAN

Point mutation:	M205V
Domain:	Not determined
General numbering (PrionDB):	-
Protein:	PRIO_HUMAN (PRNP)	Swiss-Prot Cross-reference table Family page
Other point mutations / same protein	List of mutations in PRIO_HUMAN
Family alignments	Mammalian prion proteins Prion proteins (PRP, PRNP)
Other point mutations / same position	Position 205 in Mammalian prion proteins family Position 205 in Prion proteins (PRP, PRNP) family
Reference:	A cluster of familial Creutzfeldt-Jakob disease mutations recapitulate conserved residues in Doppel: a case of molecular mimicry? Mastrangelo P, Serpell L, Dafforn T, Lesk A, Fraser P, Westaway D FEBS Lett 2002 Dec 4;532(1-2):21-6.	Medline
Other point mutations / same article	List
Text source	HTML and PDF full texts
Validation status	True positive

Relevant sentences:

M205V

Specifically , we would predict that mutations M205V , M206L , V209L arising from single nucleotide substitutions (as well as T188A , currently defined by one case) will cause F-CJD
Speci▂ally , we would predict that mutations M205V , M206L , V209L arising from single nucleotide substitutions (as well as T188A , currently de▋ed by one case) will cause F-CJD

F.Horn (priondbcmbi.ru.nl), 22-Aug-2005