PrionDB: Extraction of mutation data from the literature

2005, PrionDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation A117V was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation A117V in PRIO_RAT

Point mutation:	A117V
Domain:	Not determined
General numbering (PrionDB):	-
Protein:	PRIO_RAT (Prnp,Prn)	Swiss-Prot Cross-reference table Family page
Other point mutations / same protein	List of mutations in PRIO_RAT
Family alignments	Mammalian prion proteins Prion proteins (PRP, PRNP)
Other point mutations / same position	Position 117 in Mammalian prion proteins family Position 117 in Prion proteins (PRP, PRNP) family
Reference:	Influence of mutations associated with familial prion-related encephalopathies on biological activity of prion protein peptides. Forloni G, Angeretti N, Malesani P, Peressini E, Rodriguez Martin T, Della Torre P, Salmona M Ann Neurol 1999 Apr;45(4):489-94.	Medline
Other point mutations / same article	List
Text source	abstract
Validation status	True positive

Relevant sentences:

A117V

None of the other mutations considered , including A117V , seemed to influence the biological activities of the respective peptides

F.Horn (priondbcmbi.ru.nl), 22-Aug-2005