NucleaRDB: Pairwise Alignments

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The pairwise alignment has been generated with the "genewise" program of the Wise2 package. The output shows the protein sequence on the first line, followed by a line indicating the similarity level of the match, followed by 4 lines representing the DNA sequence; The DNA sequence descending in triplets, each triplet being a codon. The translation of each codon is shown above it.
Between the two protein sequences a line indicating the similarity of the match is printed. "+" indicates a conservative mismatch while "- "indicates a dramatic one. Mismatches are indicated by "***" in the left column in addition to "!" at the relevant position(s).


genewise $Name: wise2-2-0 $ (unreleased release)
This program is freely distributed under a GPL. See source directory
Copyright (c) GRL limited: portions of the code are from separate copyright

Query protein:       Q91601_XENLA
Comp Matrix:         blosum62.bla
Gap open:            12
Gap extension:       2
Start/End            default
Target Sequence      XL23144_2
Strand:              forward
Start/End (protein)  default
Gene Paras:          human.gf
Codon Table:         codon.table
Subs error:          1e-05
Indel error:         1e-05
Model splice?        model
Model codon bias?    flat
Model intron bias?   tied
Null model           syn
Algorithm            623

genewise output
Score 833.73 bits over entire alignment
Scores as bits over a synchronous coding model

Warning: The bits scores is not probablistically correct for single seqs
See WWW help for more info.

Q91601_XENLA       1 MLPKVESEALGLSRLHGEQGHMPDNMQVSQYKMMGYSYDDELEELCPVC 
                     MLPKVESEALGLSRLHGEQGHMPDNMQVSQYKMMGYSYDDELEELCPVC 
                     MLPKVESEALGLSRLHGEQGHMPDNMQVSQYKMMGYSYDDELEELCPVC 
XL23144_2          1 accaggtggcgctatcggcgcacgaacgtctaaagtttgggcggctcgt 
                     ttcatacactgtcgtagaagatcaatatcaaattgacaaaataatgctg 
                     ggcaggtacgagcaacgggtcggccgagcgtaggccccctatggtttgt 


Q91601_XENLA      50 GDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCIENQSCPIDKTQRKRC 
                     GDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCIENQSCPIDKTQRKRC 
                     GDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCIENQSCPIDKTQRKRC 
XL23144_2        148 ggagtgtctgccatgatagttaaagcaaaatatagacatcagaacaaat 
                     gaatcgaaagttcgaggagttagctaaaagacgtaaaggctaacagagg 
                     gcgtaatttatgctgccgaccggatgccgattctatgctgttgcggggt 


Q91601_XENLA      99 PYCRFQKCLSVGMKLEAVRADRMRGGRNKFGPMYKRDRAIKQQKKALIR 
                     PYCRFQKCLSVGMKLEAVRADRMRGGRNKFGPMYKRDRAIKQQKKALIR 
                     PYCRFQKCLSVGMKLEAVRADRMRGGRNKFGPMYKRDRAIKQQKKALIR 
XL23144_2        295 cttatcattaggaacgggcggcacggaaatgcataagcgaaccaagtac 
                     caggtaagtgtgtatactgcagtggggaatgctaagagctaaaaacttg 
                     accgcgatgtgcgggatgaacagaagacatgagcggctaaaggagtata 


Q91601_XENLA     148 ANGLKLEAIGQVIQSIPTDLTISSAIQNIHSASKGLHLNHAALPPSDYD 
                     ANGLKLEAIGQVIQSIPTDLTISSAIQNIHSASKGLHLNHAALPPSDYD 
                     ANGLKLEAIGQVIQSIPTDLTISSAIQNIHSASKGLHLNHAALPPSDYD 
XL23144_2        442 gagcacggagcgactacagcaattgacaactgtagcccacggccctgtg 
                     cagtatactgattactccatctccctaatacccagtataacctcccaaa 
                     ctagaagcatactgttcttgcttacagctcaacgagtactttgcaactc 


Q91601_XENLA     197 RSPFVTSPISMAMPPHGSLQGYQSYGHFPSRAIKSEYPDPYTSSPESIM 
                     RSPFVTSPISMAMPPHGSLQGYQSYGHFPSRAIKSEYPDPYTSSPESIM 
                     RSPFVTSPISMAMPPHGSLQGYQSYGHFPSRAIKSEYPDPYTSSPESIM 
XL23144_2        589 cactgatcaaagacccgaccgtcttgctcacgaatgtcgctaatcgtaa 
                     ggcttccctgtctccaggtagaacagatcggctacaacacacgccactt 
                     acctagccctgtgattccggtcattgctattttaagtactcataaacag 


Q91601_XENLA     246 GYSFMDSYQSSSPSNIPHLIVELLKCEPDEPQVQGKIMAYLQQEQANRS 
                     GYSFMDSYQSSSPSNIPHLIVELLKCEPDEPQVQGKIMAYLQQEQANRS 
                     GYSFMDSYQSSSPSNIPHLIVELLKCEPDEPQVQGKIMAYLQQEQANRS 
XL23144_2        736 gtttagatctatctaacccaggctatgcggccgcgaaagttccgcgaaa 
                     gacttagaacgcccatcatttattagacaacatagattcataaaacagg 
                     atatgcccgcttcttcccattacgataatataagggcgacagggaccgc 


Q91601_XENLA     295 KHDKLNTFGLMCKMADQTLFSIVEWARSSIFFRDLKKIK           
                     KHDKLNTFGLMCKMADQTLFSIVEWARSSIFFRDLKKIK           
                     KHDKLNTFGLMCKMADQTLFSIVEWARSSIFFRDLKKIK           
XL23144_2        883 acgacaatgcataaggcacttaggtgaaaattagcaaaa           
                     aaaatactgttgatcaacttcttagcgggtttgataata           
                     actactatacgcagacgaatcttggagccctcactgaaa           


//


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F.Horn (nucleardbcmbi.kun.nl), 18-Feb-2005