Swiss-Prot entry

ID   VDR_XENLA      STANDARD;      PRT;   422 AA.
AC   O13124;
DT   15-DEC-1998 (Rel. 37, Created)
DT   15-DEC-1998 (Rel. 37, Last sequence update)
DT   01-MAY-2005 (Rel. 47, Last annotation update)
DE   Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor).
GN   Name=VDR; Synonyms=NR1I1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; 
OC   Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae; 
OC   Xenopodinae; Xenopus; Xenopus. 
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Kidney;
RX   MEDLINE=97307679; PubMed=9165021 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1210/en.138.6.2347;
RA   Li Y.C., Bergwitz C., Jueppner H., Demay M.B.;
RT   "Cloning and characterization of the vitamin D receptor from Xenopus
RT   laevis.";
RL   Endocrinology 138:2347-2353(1997).
CC   -!- FUNCTION: VDR mediates the action of vitamin D3 by controlling the
CC       expression of hormone sensitive genes.
CC   -!- SUBCELLULAR LOCATION: Nuclear.
CC   -!- TISSUE SPECIFICITY: Detected in all tissues examined. Highest
CC       level in small intestine and skin.
CC   -!- DEVELOPMENTAL STAGE: First detected at stage 13. Increases
CC       gradually and peaks at stage 57-61 then decreases to the level
CC       seen in adult.
CC   -!- DOMAIN: Composed of three domains: a modulating N-terminal domain,
CC       a DNA-binding domain and a C-terminal steroid-binding domain.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; U91846; AAB58585.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   HSSP; P11473; 1KB2. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR   SMR; O13124; 22-122, 166-417.
DR   InterPro; IPR000536; Hrmon_recept_lig.
DR   InterPro; IPR001723; Stdhrmn_receptor.
DR   InterPro; IPR008946; Str_ncl_receptor.
DR   InterPro; IPR000324; VitD_receptor.
DR   InterPro; IPR001628; Znf_C4steroid.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   PRINTS; PR00350; VITAMINDR.
DR   ProDom; PD000035; Znf_C4steroid; 1.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR   HOVERGEN [Family / Alignment / Tree]
DR   BLOCKS; O13124.
DR   ProtoNet; O13124.
DR   ProtoMap; O13124.
DR   PRESAGE; O13124.
DR   DIP; O13124.
DR   ModBase; O13124.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   DNA-binding; Nuclear protein; Receptor; Transcription;
KW   Transcription regulation; Zinc-finger.
FT   DNA_BIND     22     90       Nuclear receptor-type.
FT   ZN_FING      25     45       C4-type.
FT   ZN_FING      61     85       C4-type.
FT   DOMAIN       91    188       Hinge.
FT   DOMAIN      189    422       Ligand-binding.
SQ   SEQUENCE   422 AA;  48188 MW;  C8A9F25414FEE9D5 CRC64;
     MEFMAATTSI ADTDMEFDKN VPRICGVCGD KATGFHFNAM TCEGCKGFFR RSMKRKAMFT
     CPFNGDCRIT KDNRRHCQSC RLKRCVDIGM MKEFILTDEE VQRKRQMINK RKSEEALKES
     MRPKISDEQQ KMIDILLEAH RKTFDTTYSD FNKFRPPVRE NVDPFRRITR SSSVHTQGSP
     SEDSDVFTSS PDSSEHGFFS ASLFGQFEYS SMGGKSGELS MLPHIADLVS YSIQKIIGFA
     KMIPGFRDLI AEDQIALLKS SVIEVIMLRS NQSFSLDDMS WTCGSEDFKY KVDDVTQAGH
     NMELLEPLVK FQVGLKKLDL HEEEHVLLMA ICILSPDRPG LQDKALVESI QDRLSSTLQT
     YILCKHPPPG SRLLYAKMIQ KLADLRSLNE EHSKQYRSIS FLPEHSMKLT PLMLEVFSDE
     IP
//