Swiss-Prot entry

ID   VDR_SAGOE      STANDARD;      PRT;   427 AA.
AC   Q95MH5;
DT   05-JUL-2004 (Rel. 44, Created)
DT   05-JUL-2004 (Rel. 44, Last sequence update)
DT   01-MAY-2005 (Rel. 47, Last annotation update)
DE   Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor).
GN   Name=VDR; Synonyms=NR1I1;
OS   Saguinus oedipus (Cotton-top tamarin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; 
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Platyrrhini; 
OC   Callitrichidae; Saguinus. 
OX   NCBI_TaxID=9490;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=21269858; PubMed=11376448 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1002/ajp.1016;
RA   Chun R.F., Chen H., Boldrick L., Sweet C., Adams J.S.;
RT   "Cloning, sequencing, and functional characterization of the vitamin D
RT   receptor in vitamin D-resistant New World primates.";
RL   Am. J. Primatol. 54:107-118(2001).
CC   -!- FUNCTION: Nuclear hormone receptor. VDR mediates the action of
CC       vitamin D3 by controlling the expression of hormone sensitive
CC       genes (By similarity).
CC   -!- SUBUNIT: Interacts with SMAD3. Interacts with NCOA3 and NCOA6
CC       coactivators, leading to a strong increase of transcription of
CC       target genes (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nuclear (By similarity).
CC   -!- DOMAIN: Composed of three domains: a modulating N-terminal domain,
CC       a DNA-binding domain and a C-terminal steroid-binding domain.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; AF354232; AAK48863.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   HSSP; P11473; 1KB6. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR   SMR; Q95MH5; 21-121, 171-423.
DR   InterPro; IPR000536; Hrmon_recept_lig.
DR   InterPro; IPR001723; Stdhrmn_receptor.
DR   InterPro; IPR008946; Str_ncl_receptor.
DR   InterPro; IPR000324; VitD_receptor.
DR   InterPro; IPR001628; Znf_C4steroid.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   PRINTS; PR00350; VITAMINDR.
DR   ProDom; PD000035; Znf_C4steroid; 1.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR   HOVERGEN [Family / Alignment / Tree]
DR   BLOCKS; Q95MH5.
DR   ProtoNet; Q95MH5.
DR   ProtoMap; Q95MH5.
DR   PRESAGE; Q95MH5.
DR   DIP; Q95MH5.
DR   ModBase; Q95MH5.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   DNA-binding; Nuclear protein; Phosphorylation; Receptor;
KW   Transcription; Transcription regulation; Zinc-finger.
FT   DNA_BIND     21     96       Nuclear receptor-type.
FT   ZN_FING      24     44       C4-type.
FT   ZN_FING      60     84       C4-type.
FT   DOMAIN       97    191       Hinge.
FT   DOMAIN      192    427       Ligand-binding.
SQ   SEQUENCE   427 AA;  48383 MW;  5B933C4F023B5199 CRC64;
     MEAMAASTSL PDPGDFDRNV PRICGVCGDR ATGFHFNAMT CEGCKGFFRR SMKRKALFTC
     PFNGDCRITK DNRRHCQACR LKRCVDIGMM KEFILTDEEV QRKREMILKR KEEEALKDSL
     RPKLSEEQQR IIAILLDAHH KTYDPTYSDF CQFRPPVRVN DGGGSHPSRP NSRHTPSFSG
     DSSSCCSDHY ITSPDMMDSS SFSNLDLSEE DSDDPSLTLE LSQLSMLPHL ADLVSYSIQK
     VIGFAKMIPG FRDLTSEDQI VLLKSSAIEV IMLRSNESFT MDDMSWTCGN PDYKYRISDV
     TKAGHNLELI EPLIKFQVGL KKLNLHEEEH VLLMAICIVS PDRPGVQDAA LIEAIQDRLS
     NTLQTYIRCR HPPPGSHLLY AKMIQKLADL RSLNEEHSKQ YRCLSFQPES SMKLTPLVLE
     VFGNEIS
//