Swiss-Prot entry

ID   VDR_MOUSE      STANDARD;      PRT;   422 AA.
AC   P48281;
DT   01-FEB-1996 (Rel. 33, Created)
DT   01-FEB-1996 (Rel. 33, Last sequence update)
DT   01-MAY-2005 (Rel. 47, Last annotation update)
DE   Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor).
GN   Name=Vdr; Synonyms=Nr1i1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; 
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; 
OC   Muridae; Murinae; Mus. 
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=95137405; PubMed=7835717 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1016/0378-1119(94)00735-B;
RA   Kamei Y., Kawada T., Fukuwatari T., Ono T., Kato S., Sugimoto E.;
RT   "Cloning and sequencing of the gene encoding the mouse vitamin D
RT   receptor.";
RL   Gene 152:281-282(1995).
CC   -!- FUNCTION: Nuclear hormone receptor. VDR mediates the action of
CC       vitamin D3 by controlling the expression of hormone sensitive
CC       genes.
CC   -!- SUBUNIT: Interacts with NCOA3 and NCOA6 coactivators, leading to a
CC       strong increase of transcription of target genes (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nuclear.
CC   -!- DOMAIN: Composed of three domains: a modulating N-terminal domain,
CC       a DNA-binding domain and a C-terminal steroid-binding domain.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; D31969; BAA06737.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   PIR; PC4019; PC4019.
DR   HSSP; P11473; 1KB2. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR   SMR; P48281; 21-121, 166-418.
DR   TRANSFAC; T00883; -.
DR   Ensembl; ENSMUSG00000022479; Mus_musculus
DR   MGD; MGI:103076; Vdr.
DR   GeneLynx; Vdr..
DR   SOURCE; Vdr..
DR   GO; GO:0005515; F:protein binding; IPI.
DR   GO; GO:0006874; P:calcium ion homeostasis; IMP.
DR   GO; GO:0006816; P:calcium ion transport; IMP.
DR   GO; GO:0007275; P:development; IMP.
DR   GO; GO:0050892; P:intestinal absorption; IMP.
DR   GO; GO:0001501; P:skeletal development; IMP.
DR   InterPro; IPR000536; Hrmon_recept_lig.
DR   InterPro; IPR001723; Stdhrmn_receptor.
DR   InterPro; IPR008946; Str_ncl_receptor.
DR   InterPro; IPR000324; VitD_receptor.
DR   InterPro; IPR001628; Znf_C4steroid.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   PRINTS; PR00350; VITAMINDR.
DR   ProDom; PD000035; Znf_C4steroid; 1.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR   CMR; P48281.
DR   HOVERGEN [Family / Alignment / Tree]
DR   BLOCKS; P48281.
DR   ProtoNet; P48281.
DR   ProtoMap; P48281.
DR   PRESAGE; P48281.
DR   DIP; P48281.
DR   ModBase; P48281.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   DNA-binding; Nuclear protein; Phosphorylation; Receptor;
KW   Transcription; Transcription regulation; Zinc-finger.
FT   DNA_BIND     21     96       Nuclear receptor-type.
FT   ZN_FING      24     44       C4-type.
FT   ZN_FING      60     84       C4-type.
FT   DOMAIN       97    186       Hinge.
FT   DOMAIN      187    422       Ligand-binding.
SQ   SEQUENCE   422 AA;  47852 MW;  4704CC8172445732 CRC64;
     MEAMAASTSL PDPGDFDRNV PRICGVCGDR ATGFHFNAMT CEGCKGFFRR SMKRKALFTC
     PFNGDCRITK DNRRHCQACR LKRCVDIGMM KEFILTDEEV QRKREMIMKR KEEEALKDSL
     RPKLSEEQQH IIAILLDAHH KTYDPTYADF RDFRPPIRAD VSTGSYSPRP TLSFSGDSSS
     NSDLYTPSLD MMEPASFSTM DLNEEGSDDP SVTLDLSPLS MLPHLADLVS YSIQKVIGFA
     KMIPGFRDLT SDDQIVLLKS SAIEVIMLRS NQSFTMDDMS WDCGSQDYKY DITDVSRAGH
     TLELIEPLIK FQVGLKKLNL HEEEHVLLMA ICIVSPDRPG VQDAKLVEAI QDRLSNTLQT
     YIRCRHPPPG SHQLYAKMIQ KLADLRSLNE EHSKQYRSLS FQPENSMKLT PLVLEVFGNE
     IS
//