Swiss-Prot entry

ID   VDR_COTJA      STANDARD;      PRT;   448 AA.
AC   P49701;
DT   01-FEB-1996 (Rel. 33, Created)
DT   01-FEB-1996 (Rel. 33, Last sequence update)
DT   01-MAY-2005 (Rel. 47, Last annotation update)
DE   Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor).
GN   Name=VDR; Synonyms=NR1I1;
OS   Coturnix coturnix japonica (Japanese quail).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; 
OC   Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; 
OC   Coturnix. 
OX   NCBI_TaxID=93934;
RN   [1]
RP   NUCLEOTIDE SEQUENCE (ISOFORMS A AND B).
RC   TISSUE=Chorioallantoic membrane;
RX   MEDLINE=95062315; PubMed=7972109 [NCBI, ExPASy, EBI, Israel, Japan];
RA   Elaroussi M.A., Prahl J.M., Deluca H.F.;
RT   "The avian vitamin D receptors: primary structures and their
RT   origins.";
RL   Proc. Natl. Acad. Sci. U.S.A. 91:11596-11600(1994).
CC   -!- FUNCTION: VDR mediates the action of vitamin D3 by controlling the
CC       expression of hormone sensitive genes.
CC   -!- SUBCELLULAR LOCATION: Nuclear.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative initiation;
CC         Comment=2 isoforms, A (shown here) and B, are produced by
CC         alternative initiation;
CC   -!- DOMAIN: Composed of three domains: a modulating N-terminal domain,
CC       a DNA-binding domain and a C-terminal steroid-binding domain.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; U12641; AAA56725.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   PIR; I50451; I50451.
DR   HSSP; P11473; 1KB6. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR   SMR; P49701; 41-141, 192-444.
DR   InterPro; IPR000536; Hrmon_recept_lig.
DR   InterPro; IPR001723; Stdhrmn_receptor.
DR   InterPro; IPR008946; Str_ncl_receptor.
DR   InterPro; IPR000324; VitD_receptor.
DR   InterPro; IPR001628; Znf_C4steroid.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   PRINTS; PR00350; VITAMINDR.
DR   ProDom; PD000035; Znf_C4steroid; 1.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR   HOVERGEN [Family / Alignment / Tree]
DR   BLOCKS; P49701.
DR   ProtoNet; P49701.
DR   ProtoMap; P49701.
DR   PRESAGE; P49701.
DR   DIP; P49701.
DR   ModBase; P49701.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   Alternative initiation; DNA-binding; Nuclear protein; Receptor;
KW   Transcription; Transcription regulation; Zinc-finger.
FT   CHAIN         1    448       Vitamin D3 receptor, isoform A.
FT   CHAIN        26    448       Vitamin D3 receptor, isoform B.
FT   INIT_MET     26     26       For isoform B.
FT   DNA_BIND     41    116       Nuclear receptor-type.
FT   ZN_FING      44     64       C4-type.
FT   ZN_FING      80    104       C4-type.
FT   DOMAIN      117    212       Hinge.
FT   DOMAIN      213    448       Ligand-binding.
SQ   SEQUENCE   448 AA;  50668 MW;  FCF1FC3DEAEEAF3E CRC64;
     MVSISASGGY AMPCCCESQE LQSSDMETPA VGTPEFDRNV PRICGVCGDR ATGFHFNAMT
     CEGCKGFFRR SMKRKAMFTC PFSGDCKITK DNRRHCQACR LKRCVDIGMM KEFILTDEEV
     QRKREMILKR KEEEALKESL KPKLSEEQQK VINILLEAHH KTFDTTYSDF NKFRPPVRSK
     FSSSTATHSS SVVSQDFSSE DSNDVFGSDA FGAFPEPMEP QMFSNLDLSE ESDESPSMNI
     ELPHLPMLPH LADLVSYSIQ KVIGFAKMIP GFRDLTAEDQ IALLKSSAIE VIMLRSNQSF
     TMEDMSWTCG SNDFKYKVSD VTQAGHSMDL LEPLVKFQVG LKKLNLHEEE HVLLMAICIL
     SPDRPGVQDT SLVESIQDRL SDTLQTYIRC RHPPPGSRLL YAKMIQKLAD LRSLNEEHSK
     QYRCLSFQPE HSMQLTPLVL EVFGNEIS
//