Swiss-Prot entry

ID   STF1_RAT       STANDARD;      PRT;   462 AA.
AC   P50569;
DT   01-OCT-1996 (Rel. 34, Created)
DT   01-OCT-1996 (Rel. 34, Last sequence update)
DT   01-MAY-2005 (Rel. 47, Last annotation update)
DE   Steroidogenic factor 1 (STF-1) (SF-1) (Adrenal 4 binding protein)
DE   (Steroid hormone receptor Ad4BP) (Fushi tarazu factor homolog 1).
GN   Name=Nr5a1; Synonyms=Ftzf1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; 
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; 
OC   Muridae; Murinae; Rattus. 
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Sprague-Dawley;
RX   MEDLINE=95221406; PubMed=7706291 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1074/jbc.270.13.7453;
RA   Nomura M.M.N., Smith J.;
RT   "An E box element is required for the expression of the ad4bp gene, a
RT   mammalian homologue of ftz-f1 gene, which is essential for adrenal and
RT   gonadal development.";
RL   J. Biol. Chem. 270:7453-7461(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE OF 20-293.
RX   PubMed=8395654 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1210/me.7.6.776;
RA   Lynch J.P., Lala D.S., Peluso J.J., Luo W., Parker K.L., White B.A.;
RT   "Steroidogenic factor 1, an orphan nuclear receptor, regulates the
RT   expression of the rat aromatase gene in gonadal tissues.";
RL   Mol. Endocrinol. 7:776-786(1993).
CC   -!- FUNCTION: Seems to be essential for sexual differentiation and
CC       formation of the primary steroidogenic tissues. Binds to the Ad4
CC       site found in the promoter region of steroidogenic P-450 genes
CC       such as CYP11A, CYP11B and CYP21B. Also regulates the Muellerian
CC       inhibiting substance (AMH) gene as well as the AHCH and STAR
CC       genes.
CC   -!- SUBUNIT: Binds DNA as a monomer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nuclear.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR5
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; D42156; BAA07722.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   EMBL; D42152; BAA07722.1; JOINED. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   EMBL; D42153; BAA07722.1; JOINED. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   EMBL; D42155; BAA07722.1; JOINED. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   PIR; A56120; A56120.
DR   HSSP; P03372; 1HCQ. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR   TRANSFAC; T04002; -.
DR   Ensembl; ENSRNOG00000012682; Rattus_norvegicus
DR   RGD; 68350; Nr5a1.
DR   InterPro; IPR000536; Hrmon_recept_lig.
DR   InterPro; IPR001723; Stdhrmn_receptor.
DR   InterPro; IPR008946; Str_ncl_receptor.
DR   InterPro; IPR000324; VitD_receptor.
DR   InterPro; IPR001628; Znf_C4steroid.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   PRINTS; PR00350; VITAMINDR.
DR   ProDom; PD000035; Znf_C4steroid; 1.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR   CMR; P50569.
DR   HOVERGEN [Family / Alignment / Tree]
DR   BLOCKS; P50569.
DR   ProtoNet; P50569.
DR   ProtoMap; P50569.
DR   PRESAGE; P50569.
DR   DIP; P50569.
DR   ModBase; P50569.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   DNA-binding; Nuclear protein; Receptor; Transcription;
KW   Transcription regulation; Zinc-finger.
FT   DNA_BIND     10     85       Nuclear receptor-type.
FT   ZN_FING      13     33       C4-type.
FT   ZN_FING      49     73       C4-type.
FT   DOMAIN      267    309       Ligand-binding (Potential).
FT   CONFLICT    150    150       K -> R (in Ref. 2).
SQ   SEQUENCE   462 AA;  52087 MW;  89963798A66FFE04 CRC64;
     MDYSYDEDLD ELCPVCGDKV SGYHYGLLTC ESCKGFFKRT VQNNKHYTCT ESQSCKIDKT
     QRKRCPFCRF QKCLTVGMRL EAVRADRMRG GRNKFGPMYK RDRALKQQKK AQIRANGFKL
     ETGPPMGVPP PPPPPPDYML PPSLHAPEPK ALVSGPPSGP LGDFGAPSLP MAVPGPHGPL
     AGYLYPAFSN RTIKSEYPEP YASPPQQPGP PYSYPEPFSG GPNVPELILQ LLQLEPEEDQ
     VRARIVGCLQ EPAKSRPDQP APFSLLCRMA DQTFISIVDW ARRCMVFKEL EVADQMTLLQ
     NCWSELLVLD HIYRQVQYGK EDSILLVTGQ EVELSTVAVQ AGSLLHSLVL RAQELVLQLH
     ALQLDRQEFV CLKFLILFSL DVKFLNNHSL VKDAQEKANA ALLDYTLCHY PHCGDKFQQL
     LLCLVEVRAL SMQAKEYLYH KHLGNEMPRN NLLIEMLQAK QT
//