Swiss-Prot entry

ID   STF1_PIG       STANDARD;      PRT;   461 AA.
AC   P79387;
DT   30-MAY-2000 (Rel. 39, Created)
DT   30-MAY-2000 (Rel. 39, Last sequence update)
DT   01-MAY-2005 (Rel. 47, Last annotation update)
DE   Steroidogenic factor 1 (STF-1) (SF-1) (Adrenal 4 binding protein)
DE   (Steroid hormone receptor Ad4BP) (Fushi tarazu factor homolog 1).
GN   Name=NR5A1; Synonyms=FTZF1;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; 
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; 
OC   Sus. 
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=98389426; PubMed=9724033 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1210/en.139.9.3803;
RA   Pilon N., Behdjani R., Daneau I., Lussier J.G., Silversides D.W.;
RT   "Porcine steroidogenic factor-1 gene (pSF-1) expression and analysis
RT   of embryonic pig gonads during sexual differentiation.";
RL   Endocrinology 139:3803-3812(1998).
CC   -!- FUNCTION: Seems to be essential for sexual differentiation and
CC       formation of the primary steroidogenic tissues. Binds to the Ad4
CC       site found in the promoter region of steroidogenic P-450 genes
CC       such as CYP11A, CYP11B and CYP21B. Also regulates the Muellerian
CC       inhibiting substance (AMH) gene as well as the AHCH and STAR genes
CC       (By similarity).
CC   -!- SUBUNIT: Binds DNA as a monomer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nuclear (By similarity).
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR5
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
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CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
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DR   EMBL; U84399; AAC64209.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   HSSP; P03372; 1HCQ. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR   TRANSFAC; T04015; -.
DR   InterPro; IPR000536; Hrmon_recept_lig.
DR   InterPro; IPR001723; Stdhrmn_receptor.
DR   InterPro; IPR008946; Str_ncl_receptor.
DR   InterPro; IPR000324; VitD_receptor.
DR   InterPro; IPR001628; Znf_C4steroid.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   PRINTS; PR00350; VITAMINDR.
DR   ProDom; PD000035; Znf_C4steroid; 1.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR   HOVERGEN [Family / Alignment / Tree]
DR   BLOCKS; P79387.
DR   ProtoNet; P79387.
DR   ProtoMap; P79387.
DR   PRESAGE; P79387.
DR   DIP; P79387.
DR   ModBase; P79387.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   DNA-binding; Nuclear protein; Receptor; Transcription;
KW   Transcription regulation; Zinc-finger.
FT   DNA_BIND     10     85       Nuclear receptor-type.
FT   ZN_FING      13     33       C4-type.
FT   ZN_FING      49     73       C4-type.
FT   DOMAIN      230    461       Important for dimerization.
SQ   SEQUENCE   461 AA;  51613 MW;  32FF67B747F32DB0 CRC64;
     MDYWYDEDLD ELCPVCGDKV SGYHYGLLTC ETCKGFFKRT VQNNKHYTCT ESQSCKIDKT
     QRKRCPFCRF QKCLTVGMRL EAVRADGMRG GRNKFGPMYK RDRALKQQKK AQIRANGFKL
     ETGPPMGVAP PPPPPPDYML PPGLHAPEPK GLAAGPPTGP LGDFGAPTLP MAVPSAHGPL
     AGYLYPAFPG RAIKSEYPEP YASPPQPGPP YGYPEPFSGG PGVPELIVQL LQLEPDEDQV
     RARIVGCLQE PAKGRPDQPA PFSLLCRMAD QTFISIVDWA RRCMVFKELE VADQMTLLQN
     CWSELHVFDH IYRQIQHGKE GSILLVTGQE VELTTVAAQA GSLLHGLVLR AQELVLQLHA
     LQLDRQEFVC LKFLILFSLD VKFLNNHSLV KDAQEKANAA LLDYTLCHYP HCGDKFQQLL
     LCLVEVRALS MQAKEYLYHK HLGNEMPRNN LLIEMLQAKQ T
//