Swiss-Prot entry
ID STF1_MOUSE STANDARD; PRT; 462 AA.
AC P33242;
DT 01-FEB-1994 (Rel. 28, Created)
DT 01-OCT-1996 (Rel. 34, Last sequence update)
DT 01-MAY-2005 (Rel. 47, Last annotation update)
DE Steroidogenic factor 1 (STF-1) (SF-1) (Adrenal 4 binding protein)
DE (Steroid hormone receptor Ad4BP) (Fushi tarazu factor homolog 1)
DE (Embryonal LTR binding protein) (ELP) (Embryonal long terminal repeat-
DE binding protein) (Steroid hydroxylase positive regulator).
GN Name=Nr5a1; Synonyms=Ftzf1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muridae; Murinae; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE (ISOFORM 2).
RX MEDLINE=92186861; PubMed=1545809 [NCBI, ExPASy, EBI, Israel, Japan];
RA Tsukiyama T., Ueda H., Hirose S., Niwa O.;
RT "Embryonal long terminal repeat-binding protein is a murine homolog of
RT FTZ-F1, a member of the steroid receptor superfamily.";
RL Mol. Cell. Biol. 12:1286-1291(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE (ISOFORM 1).
RC STRAIN=BALB/c; TISSUE=Embryonic carcinoma;
RX MEDLINE=94019394; PubMed=8413309 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1210/me.7.7.852;
RA Ikeda Y., Lala D.S., Luo X., Kim E., Moisan M.P., Parker K.L.;
RT "Characterization of the mouse FTZ-F1 gene, which encodes a key
RT regulator of steroid hydroxylase gene expression.";
RL Mol. Endocrinol. 7:852-860(1993).
RN [3]
RP SUBUNITS.
RX MEDLINE=93361012; PubMed=8395013 [NCBI, ExPASy, EBI, Israel, Japan];
RA Wilson T.E., Fahrner T.J., Milbrandt J.;
RT "The orphan receptors NGFI-B and steroidogenic factor 1 establish
RT monomer binding as a third paradigm of nuclear receptor-DNA
RT interaction.";
RL Mol. Cell. Biol. 13:5794-5804(1993).
CC -!- FUNCTION: Seems to be essential for sexual differentiation and
CC formation of the primary steroidogenic tissues. Binds to the Ad4
CC site found in the promoter region of steroidogenic P-450 genes
CC such as CYP11A, CYP11B and CYP21B. Also regulates the Muellerian
CC inhibiting substance (AMH) gene as well as the AHCH and STAR
CC genes. Transcription repressor of the Moloney leukemia virus long
CC terminal repeat in undifferentiated murine embryonal carcinoma
CC cells. It binds the sequence element 5'-TCAAGGTCA-3'.
CC -!- SUBUNIT: Binds DNA as a monomer.
CC -!- SUBCELLULAR LOCATION: Nuclear.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P33242-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P33242-2; Sequence=VSP_003715;
CC -!- DEVELOPMENTAL STAGE: Expressed during early embryonic development.
CC Expressed only in undifferentiated embryonal carcinoma cells.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR5
CC subfamily.
CC -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
CC --------------------------------------------------------------------------
CC This Swiss-Prot entry is copyright. It is produced through a collaboration
CC between the Swiss Institute of Bioinformatics and the EMBL outstation -
CC the European Bioinformatics Institute. There are no restrictions on its
CC use as long as its content is in no way modified and this statement is not
CC removed.
CC --------------------------------------------------------------------------
DR EMBL; D10584; BAA01441.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; S65878; AAB28338.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; S65875; AAB28338.1; JOINED. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; S65919; AAB28338.1; JOINED. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; S65876; AAB28338.1; JOINED. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; S65877; AAB28338.1; JOINED. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; S65876; AAB28339.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; S65875; AAB28339.1; JOINED. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; S65919; AAB28339.1; JOINED. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR PIR; A40716; A40716.
DR HSSP; P03372; 1HCQ. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR TRANSFAC; T00251; -.
DR TRANSFAC; T01147; -.
DR Ensembl; ENSMUSG00000026751; Mus_musculus
DR MGD; MGI:1346833; Nr5a1.
DR GeneLynx; Nr5a1..
DR SOURCE; Nr5a1..
DR GO; GO:0005634; C:nucleus; IDA.
DR GO; GO:0003677; F:DNA binding; IDA.
DR GO; GO:0005515; F:protein binding; IPI.
DR GO; GO:0016563; F:transcriptional activator activity; IDA.
DR GO; GO:0001553; P:luteinization; IMP.
DR GO; GO:0008584; P:male gonad development; IMP.
DR GO; GO:0045944; P:positive regulation of transcription from P...; IDA.
DR InterPro; IPR000536; Hrmon_recept_lig.
DR InterPro; IPR001723; Stdhrmn_receptor.
DR InterPro; IPR008946; Str_ncl_receptor.
DR InterPro; IPR000324; VitD_receptor.
DR InterPro; IPR001628; Znf_C4steroid.
DR InterPro; Graphical view of domain structure.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR Pfam; Graphical view of domain structure.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR PRINTS; PR00350; VITAMINDR.
DR ProDom; PD000035; Znf_C4steroid; 1.
DR ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR CMR; P33242.
DR HOVERGEN [Family / Alignment / Tree]
DR BLOCKS; P33242.
DR ProtoNet; P33242.
DR ProtoMap; P33242.
DR PRESAGE; P33242.
DR DIP; P33242.
DR ModBase; P33242.
DR SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW Alternative splicing; DNA-binding; Nuclear protein; Receptor;
KW Repressor; Transcription; Transcription regulation; Zinc-finger.
FT DNA_BIND 10 85 Nuclear receptor-type.
FT ZN_FING 13 33 C4-type.
FT ZN_FING 49 73 C4-type.
FT DOMAIN 267 309 Ligand-binding (Potential).
FT VARSPLIC 333 462 ELSTVAVQAGSLLHSLVLRAQELVLQLHALQLDRQEFVCLK
FT FLILFSLDVKFLNNHSLVKDAQEKANAALLDYTLCHYPHCG
FT DKFQQLLLCLVEVRALSMQAKEYLYHKHLGNEMPRNNLLIE
FT MLQAKQT -> TELVKPLVLHNPRPLRADSGHPKFQIQGHA
FT LARLLCVLGPFEEPQCGMVSGSSYRR (in isoform
FT 2).
FT /FTId=VSP_003715.
FT CONFLICT 164 164 I -> F (in Ref. 2).
FT CONFLICT 172 172 S -> A (in Ref. 2).
FT CONFLICT 256 256 G -> R (in Ref. 2).
FT CONFLICT 328 328 S -> T (in Ref. 2).
SQ SEQUENCE 462 AA; 51946 MW; CA27CA6CABC0213A CRC64;
MDYSYDEDLD ELCPVCGDKV SGYHYGLLTC ESCKGFFKRT VQNNKHYTCT ESQSCKIDKT
QRKRCPFCRF QKCLTVGMRL EAVRADRMRG GRNKFGPMYK RDRALKQQKK AQIRANGFKL
ETGPPMGVPP PPPPPPDYML PPSLHAPEPK ALVSGPPSGP LGDIGAPSLP MSVPGPHGPL
AGYLYPAFSN RTIKSEYPEP YASPPQQPGP PYSYPEPFSG GPNVPELILQ LLQLEPEEDQ
VRARIVGCLQ EPAKSGSDQP APFSLLCRMA DQTFISIVDW ARRCMVFKEL EVADQMTLLQ
NCWSELLVLD HIYRQVQYGK EDSILLVSGQ EVELSTVAVQ AGSLLHSLVL RAQELVLQLH
ALQLDRQEFV CLKFLILFSL DVKFLNNHSL VKDAQEKANA ALLDYTLCHY PHCGDKFQQL
LLCLVEVRAL SMQAKEYLYH KHLGNEMPRN NLLIEMLQAK QT
//