Swiss-Prot entry

ID   STF1_HORSE     STANDARD;      PRT;   461 AA.
AC   Q9GKL2;
DT   05-JUL-2004 (Rel. 44, Created)
DT   05-JUL-2004 (Rel. 44, Last sequence update)
DT   01-MAY-2005 (Rel. 47, Last annotation update)
DE   Steroidogenic factor 1 (STF-1) (SF-1).
GN   Name=NR5A1; Synonyms=SF1;
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; 
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. 
OX   NCBI_TaxID=9796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Corpus luteum, and Ovarian follicle;
RX   MEDLINE=20557666; PubMed=11108279 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1210/en.141.12.4647;
RA   Boerboom D., Pilon N., Behdjani R., Silversides D.W., Sirois J.;
RT   "Expression and regulation of transcripts encoding two members of the
RT   NR5A nuclear receptor subfamily of orphan nuclear receptors,
RT   steroidogenic factor-1 and NR5A2, in equine ovarian cells during the
RT   ovulatory process.";
RL   Endocrinology 141:4647-4656(2000).
CC   -!- FUNCTION: Seems to be essential for sexual differentiation and
CC       formation of the primary steroidogenic tissues.
CC   -!- SUBUNIT: Binds DNA as a monomer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nuclear (By similarity).
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR5
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
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CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
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DR   EMBL; AF203911; AAG35648.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   HSSP; P03372; 1HCQ. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR   InterPro; IPR000536; Hrmon_recept_lig.
DR   InterPro; IPR001723; Stdhrmn_receptor.
DR   InterPro; IPR008946; Str_ncl_receptor.
DR   InterPro; IPR000324; VitD_receptor.
DR   InterPro; IPR001628; Znf_C4steroid.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   PRINTS; PR00350; VITAMINDR.
DR   ProDom; PD000035; Znf_C4steroid; 1.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR   HOVERGEN [Family / Alignment / Tree]
DR   BLOCKS; Q9GKL2.
DR   ProtoNet; Q9GKL2.
DR   ProtoMap; Q9GKL2.
DR   PRESAGE; Q9GKL2.
DR   DIP; Q9GKL2.
DR   ModBase; Q9GKL2.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   DNA-binding; Nuclear protein; Receptor; Repressor; Transcription;
KW   Transcription regulation; Zinc-finger.
FT   DNA_BIND     10     85       Nuclear receptor-type.
FT   ZN_FING      13     33       C4-type.
FT   ZN_FING      49     73       C4-type.
FT   DOMAIN      266    308       Ligand-binding (Potential).
SQ   SEQUENCE   461 AA;  51644 MW;  85909263A89A1A9D CRC64;
     MDYSYDEDLD ELCPVCGDKV SGYHYGLLTC ESCKGFFKRT VQNNKHYTCT ESQSCKIDKT
     LRKRCPFCRF QKCLTVGMRL EAVRADRMRG GRNKFGPMYK RDRALKQQKK AQIRANGFKL
     ETGPPMGVPP PPPPPPDYML PPGLHVPEPK GLASGPPAGP LGDFGAPALP MAVPSTNGPL
     AGYLYPAFPG RAIKSEYPEP YASPPQPGPP YGYPEPFSGG PGVPELILQL LQLEPDEDQV
     RARIIGCLQE PAKGRPDQPA SFNLLCRMAD QTFISIVDWA RRCMVFKELE VADQMTLLQN
     CWSELLVFDH IYRQVQHGKE GSTLLVTGQE VELTTVAAQA GSLLHGLVLR AQELVLQMHA
     LQLDRQEFVC LKFLILFSLD VKFLNNHSLV KDAQEKANTA LLDYTLCHYP HCGDKFQQLL
     LCLVEVRALS MQAKEYLYHK HLGNEMPRNN LLIEMLQAKQ T
//