Swiss-Prot entry
ID RRG_XENLA STANDARD; PRT; 476 AA.
AC P28699; P51127; P79878; P79879;
DT 01-DEC-1992 (Rel. 24, Created)
DT 01-OCT-1996 (Rel. 34, Last sequence update)
DT 01-MAY-2005 (Rel. 47, Last annotation update)
DE Retinoic acid receptor gamma (RAR-gamma).
GN Name=RARG; Synonyms=NR1B3;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae;
OC Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE (ISOFORM RAR-GAMMA-1).
RX MEDLINE=92196110; PubMed=1312717 [NCBI, ExPASy, EBI, Israel, Japan];
RA Blumberg B., Mangelsdorf D.J., Dyck J.A., Bittner D.A., Evans R.M.,
RA de Robertis E.M.;
RT "Multiple retinoid-responsive receptors in a single cell: families of
RT retinoid 'X' receptors and retinoic acid receptors in the Xenopus
RT egg.";
RL Proc. Natl. Acad. Sci. U.S.A. 89:2321-2325(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE (ISOFORM RAR-GAMMA-2).
RX MEDLINE=91115103; PubMed=1846602 [NCBI, ExPASy, EBI, Israel, Japan];
RA Ellinger-Ziegelbauer H., Dreyer C.;
RT "A retinoic acid receptor expressed in the early development of
RT Xenopus laevis.";
RL Genes Dev. 5:94-104(1991).
RN [3]
RP NUCLEOTIDE SEQUENCE (ISOFORM RAR-GAMMA-2).
RX MEDLINE=96191149; PubMed=8641047 [NCBI, ExPASy, EBI, Israel, Japan];
RA Crawford M.J., Liversage R.A., Varmuza S.L.;
RT "Two isoforms of Xenopus retinoic acid receptor gamma 2 (B) exhibit
RT differential expression and sensitivity to retinoic acid during
RT embryogenesis.";
RL Dev. Genet. 17:291-302(1995).
CC -!- FUNCTION: This is a receptor for retinoic acid. This metabolite
CC has profound effects on vertebrate development. Retinoic acid is a
CC morphogen and is a powerful teratogen. This receptor controls cell
CC function by directly regulating gene expression.
CC -!- SUBCELLULAR LOCATION: Nuclear.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Comment=Isoforms differ in their N-terminal section;
CC Name=RAR-gamma-1;
CC IsoId=P28699-1; Sequence=Displayed;
CC Name=RAR-gamma-2;
CC IsoId=P28699-2; Sequence=VSP_003642;
CC -!- DEVELOPMENTAL STAGE: It is synthesized during oogenesis and
CC persists during early cleavage. It accumulates at gastrulation
CC (stage 10), peaks in quantity during neurulation (stage 17), then
CC drops to a low level after stage 26.
CC -!- DOMAIN: Composed of three domains: a modulating N-terminal domain,
CC a DNA-binding domain and a C-terminal steroid-binding domain.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC subfamily.
CC -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
CC --------------------------------------------------------------------------
CC This Swiss-Prot entry is copyright. It is produced through a collaboration
CC between the Swiss Institute of Bioinformatics and the EMBL outstation -
CC the European Bioinformatics Institute. There are no restrictions on its
CC use as long as its content is in no way modified and this statement is not
CC removed.
CC --------------------------------------------------------------------------
DR EMBL; L11444; -; NOT_ANNOTATED_CDS. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; X59396; CAA42039.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; S82175; AAB47116.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; S82173; AAB47115.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR PIR; A38592; A38592.
DR PIR; B41977; B41977.
DR HSSP; P13631; 1FCY. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR SMR; P28699; 109-183, 205-438.
DR TRANSFAC; T01358; -.
DR InterPro; IPR000536; Hrmon_recept_lig.
DR InterPro; IPR001723; Stdhrmn_receptor.
DR InterPro; IPR008946; Str_ncl_receptor.
DR InterPro; IPR001628; Znf_C4steroid.
DR InterPro; Graphical view of domain structure.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR Pfam; Graphical view of domain structure.
DR PRINTS; PR01292; RETNOICACIDR.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR ProDom; PD000035; Znf_C4steroid; 1.
DR ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR HOVERGEN [Family / Alignment / Tree]
DR BLOCKS; P28699.
DR ProtoNet; P28699.
DR ProtoMap; P28699.
DR PRESAGE; P28699.
DR DIP; P28699.
DR ModBase; P28699.
DR SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW Alternative splicing; DNA-binding; Multigene family; Nuclear protein;
KW Receptor; Transcription; Transcription regulation; Zinc-finger.
FT DOMAIN 1 109 Modulating.
FT DNA_BIND 110 175 Nuclear receptor-type.
FT ZN_FING 110 130 C4-type.
FT ZN_FING 146 170 C4-type.
FT DOMAIN 176 221 Hinge.
FT DOMAIN 222 442 Ligand-binding.
FT DOMAIN 184 189 Nuclear localization signal (Potential).
FT VARSPLIC 1 82 MANSSKERLCGAGAPLGHANGFPPSVYPFAFSGGIRRSPPF
FT EVLANGGFFRSFPTDLPKEMASLSLTMGAAERSAHSDCIST
FT -> MYDCMEAFPLMPRPLYDMSPQGPCMLRKAGCFGGLDPF
FT GWMQSHSMQS (in isoform RAR-gamma-2).
FT /FTId=VSP_003642.
FT CONFLICT 242 242 Q -> R (in Ref. 3).
FT CONFLICT 381 381 A -> G (in Ref. 2).
SQ SEQUENCE 476 AA; 53034 MW; 2AB7728B0448F7FF CRC64;
MANSSKERLC GAGAPLGHAN GFPPSVYPFA FSGGIRRSPP FEVLANGGFF RSFPTDLPKE
MASLSLTMGA AERSAHSDCI STVETQSTSS EEMVPSSPSP PPPPRVYKPC FVCNDKSSGY
HYGVSSCEGC KGFFRRSIQK NMVYTCHRDK NCQINKVTRN RCQFCRLQKC FQVGMSKEAV
RNDRNKKKKE IKEEVVLPDS YEMPPEMEEL IQKVSKAHQE TFPSLCQLGK YTTNSSADQR
VQLDLGLWDK FSELSTKCII KIVEFAKRLP GFTTLTIADQ ITLLKSACLD ILMLRICTRY
TPEQDTMTFS DGLTLNRTQM HNAGFGPLTD LVFSFADQLL PLEMDDTETG LLSAICLICG
DRMDLEEPEK VEKLQEPLLE ALKFYARRRR PDKPYMFPRM LMKITDLRGI STKGAERAIT
LKLEIPGPMP PLIREMLENP EAFEDGAATP KPSERSSSES SNGSPTGEDS SGSKTP
//