Swiss-Prot entry
ID RRG_NOTVI STANDARD; PRT; 505 AA.
AC P18516; Q04643;
DT 01-NOV-1990 (Rel. 16, Created)
DT 01-NOV-1995 (Rel. 32, Last sequence update)
DT 01-MAY-2005 (Rel. 47, Last annotation update)
DE Retinoic acid receptor gamma (RAR-gamma) (Retinoic acid receptor
DE delta) (RAR-delta).
GN Name=RARG; Synonyms=NR1B3;
OS Notophthalmus viridescens (Eastern newt) (Triturus viridescens).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Amphibia; Batrachia; Caudata; Salamandroidea; Salamandridae;
OC Notophthalmus.
OX NCBI_TaxID=8316;
RN [1]
RP NUCLEOTIDE SEQUENCE (ISOFORMS DELTA-1 AND DELTA-2).
RC TISSUE=Tail;
RX MEDLINE=93183772; PubMed=8382939 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1016/0925-4773(93)90091-B;
RA Ragsdale C.W. Jr., Gates P.B., Hill D.S., Brockes J.P.;
RT "Delta retinoic acid receptor isoform delta 1 is distinguished by its
RT exceptional N-terminal sequence and abundance in the limb regeneration
RT blastema.";
RL Mech. Dev. 40:99-112(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE OF 52-505.
RX MEDLINE=90015190; PubMed=2552324 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1038/341654a0;
RA Ragsdale C.W. Jr., Petkovich M., Gates P.B., Chambon P., Brockes J.P.;
RT "Identification of a novel retinoic acid receptor in regenerative
RT tissues of the newt.";
RL Nature 341:654-657(1989).
RN [3]
RP PARTIAL NUCLEOTIDE SEQUENCE.
RX MEDLINE=89127522; PubMed=2536901 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1038/337566a0;
RA Giguere V., Ong E.S., Evans R.M., Tabin C.J.;
RT "Spatial and temporal expression of the retinoic acid receptor in the
RT regenerating amphibian limb.";
RL Nature 337:566-569(1989).
CC -!- FUNCTION: This is a receptor for retinoic acid. This metabolite
CC has profound effects on vertebrate development. Retinoic acid is a
CC morphogen and is a powerful teratogen. This receptor controls cell
CC function by directly regulating gene expression.
CC -!- SUBCELLULAR LOCATION: Nuclear.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=Delta-1A;
CC IsoId=P18516-1; Sequence=Displayed;
CC Note=Isoform Delta-1B is produced by alternative initiation at
CC Met-52 of isoform Delta-1A;
CC Name=Delta-2;
CC IsoId=P18516-2; Sequence=VSP_003643;
CC Event=Alternative initiation;
CC Comment=2 isoforms, Delta-1A (shown here) and Delta-1B, are
CC produced by alternative initiation at Met-1 and Met-52;
CC -!- TISSUE SPECIFICITY: Isoform Delta-1A and Isoform Delta-1B are most
CC abundant in regenerating limbs, tails, and the anterior half of
CC the lower jaw. Isoform Delta-2 is broadly and uniformly
CC distributed.
CC -!- DOMAIN: Composed of three domains: a modulating N-terminal domain,
CC a DNA-binding domain and a C-terminal steroid-binding domain.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC subfamily.
CC -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
CC --------------------------------------------------------------------------
CC This Swiss-Prot entry is copyright. It is produced through a collaboration
CC between the Swiss Institute of Bioinformatics and the EMBL outstation -
CC the European Bioinformatics Institute. There are no restrictions on its
CC use as long as its content is in no way modified and this statement is not
CC removed.
CC --------------------------------------------------------------------------
DR EMBL; X69944; CAA49564.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; X69944; CAA49565.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; X69944; CAA49562.1; ALT_INIT. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; X69945; CAA49566.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; X17586; CAA35603.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR PIR; S06124; S06124.
DR PIR; S31516; S31516.
DR HSSP; P19793; 1DSZ. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR SMR; P18516; 142-216, 237-470.
DR InterPro; IPR000536; Hrmon_recept_lig.
DR InterPro; IPR001723; Stdhrmn_receptor.
DR InterPro; IPR008946; Str_ncl_receptor.
DR InterPro; IPR001628; Znf_C4steroid.
DR InterPro; Graphical view of domain structure.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR Pfam; Graphical view of domain structure.
DR PRINTS; PR01292; RETNOICACIDR.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR ProDom; PD000035; Znf_C4steroid; 1.
DR ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR HOVERGEN [Family / Alignment / Tree]
DR BLOCKS; P18516.
DR ProtoNet; P18516.
DR ProtoMap; P18516.
DR PRESAGE; P18516.
DR DIP; P18516.
DR ModBase; P18516.
DR SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW Alternative initiation; Alternative splicing; DNA-binding;
KW Multigene family; Nuclear protein; Receptor; Transcription;
KW Transcription regulation; Zinc-finger.
FT CHAIN 1 505 Retinoic acid receptor gamma, isoform
FT Delta-1A.
FT CHAIN 52 505 Retinoic acid receptor gamma, isoform
FT Delta-1B.
FT INIT_MET 52 52 For isoform Delta-1B.
FT DOMAIN 52 142 Modulating.
FT DNA_BIND 143 208 Nuclear receptor-type.
FT ZN_FING 143 163 C4-type.
FT ZN_FING 179 203 C4-type.
FT DOMAIN 131 137 Poly-Pro.
FT DOMAIN 219 222 Poly-Lys.
FT DOMAIN 419 422 Poly-Arg.
FT DOMAIN 209 254 Hinge.
FT DOMAIN 255 474 Ligand-binding.
FT VARSPLIC 1 114 MMKFSDTASCRDGGERPEEEGKGAGGRSKLRMGKEEFTGSV
FT GKEEAAAVASMSSSKDRICSTSTQLSQLHGFPPSMYPFAFS
FT SNMRGSPPFDLTNGGAYFRSFPTDLPKEMASL -> MYDCM
FT EAFMLAPHPLYDVTNPGACMLRKARLSPCFGGLDPFGWPQP
FT ASLQ (in isoform Delta-2).
FT /FTId=VSP_003643.
FT CONFLICT 281 281 H -> D (in Ref. 3).
FT CONFLICT 303 303 G -> S (in Ref. 3).
FT CONFLICT 497 497 G -> A (in Ref. 3).
SQ SEQUENCE 505 AA; 56629 MW; 0466F549C962E262 CRC64;
MMKFSDTASC RDGGERPEEE GKGAGGRSKL RMGKEEFTGS VGKEEAAAVA SMSSSKDRIC
STSTQLSQLH GFPPSMYPFA FSSNMRGSPP FDLTNGGAYF RSFPTDLPKE MASLSVETQS
TSSEEMVPSS PSPPPPPRVY KPCFVCNDKS SGYHYGVSSC EGCKGFFRRS IQKNMVYTCH
RDKNCQINKV TRNRCQYCRL QKCFEVGMSK EAVRNDRNKK KKEIKEEVVT DSYEMPPEME
ALIQKVSKAH QETFPSLCQL GKYTTNSSAD HRVQLDLGLW HKFSELATKC IIKIVEFAKR
LPGFATLTIA DQITLLKAAC LDILMLRICT RYTPEQDTMT FSDGLTLNRT QMHNAGFGPL
TDLVFAFAEQ LLPLEMDDTE TGLLSAICLI CGDRMDLEEP EKVDKLQEPL LEALKIYARR
RRPNKPYMFP RMLMKITDLR GISTKGAERA ITLKMEIPGP MPPLIREMLE NPEAFEDDAS
PPPKSEQKPI KVEEKPGEKT STKDP
//