Swiss-Prot entry
ID RORA_HUMAN STANDARD; PRT; 556 AA.
AC P35398; P35397; P35399; P45445; Q96H83;
DT 01-JUN-1994 (Rel. 29, Created)
DT 01-JUN-1994 (Rel. 29, Last sequence update)
DT 01-MAY-2005 (Rel. 47, Last annotation update)
DE Nuclear receptor ROR-alpha (Nuclear receptor RZR-alpha).
GN Name=RORA; Synonyms=NR1F1, RZRA;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE (ISOFORMS ALPHA-1; ALPHA-2 AND ALPHA-3).
RC TISSUE=Retina, and Testis;
RX MEDLINE=95011560; PubMed=7926749 [NCBI, ExPASy, EBI, Israel, Japan];
RA Giguere V., Tini M., Flock G., Ong E., Evans R.M., Otulakowski G.;
RT "Isoform-specific amino-terminal domains dictate DNA-binding
RT properties of ROR alpha, a novel family of orphan hormone nuclear
RT receptors.";
RL Genes Dev. 8:538-553(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE (ISOFORM ALPHA-4).
RC TISSUE=Umbilical vein endothelial cells;
RX MEDLINE=93356815; PubMed=7916608 [NCBI, ExPASy, EBI, Israel, Japan];
RA Becker-Andre M., Andre E., Delamarter J.F.;
RT "Identification of nuclear receptor mRNAs by RT-PCR amplification of
RT conserved zinc-finger motif sequences.";
RL Biochem. Biophys. Res. Commun. 194:1371-1379(1993).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA-1).
RC TISSUE=Muscle;
RX MEDLINE=22388257; PubMed=12477932 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1073/pnas.242603899;
RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G.,
RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D.,
RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K.,
RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F.,
RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L.,
RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E.,
RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C.,
RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J.,
RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H.,
RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W.,
RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A.,
RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A.,
RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C.,
RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M.,
RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E.,
RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.;
RT "Generation and initial analysis of more than 15,000 full-length human
RT and mouse cDNA sequences.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
CC -!- FUNCTION: Orphan nuclear receptor. Binds DNA as a monomer to
CC hormone response elements (HRE) containing a single core motif
CC half-site preceded by a short A-T-rich sequence. This isomer binds
CC to the consensus sequence 5'-[AT][TA]A[AT][CGT]TAGGTCA-3'.
CC -!- SUBUNIT: Monomer.
CC -!- SUBCELLULAR LOCATION: Nuclear (Probable).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=Alpha-2;
CC IsoId=P35398-1; Sequence=Displayed;
CC Name=Alpha-1;
CC IsoId=P35398-2; Sequence=VSP_003655;
CC Name=Alpha-3;
CC IsoId=P35398-3; Sequence=VSP_003656;
CC Name=Alpha-4;
CC IsoId=P35398-4; Sequence=VSP_003657;
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC subfamily.
CC -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
CC --------------------------------------------------------------------------
CC This Swiss-Prot entry is copyright. It is produced through a collaboration
CC between the Swiss Institute of Bioinformatics and the EMBL outstation -
CC the European Bioinformatics Institute. There are no restrictions on its
CC use as long as its content is in no way modified and this statement is not
CC removed.
CC --------------------------------------------------------------------------
DR EMBL; U04897; AAA62658.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; U04898; AAA62659.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; U04899; AAA62660.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; L14611; AAA02963.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; BC008831; AAH08831.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR PIR; B53196; B53196.
DR PIR; C53196; C53196.
DR PDB; 1N83; X-ray; A=292-555. [ExPASy / RCSB]
DR PDB; 1S0X; X-ray; A=287-556. [ExPASy / RCSB]
DR TRANSFAC; T01527; -.
DR TRANSFAC; T01528; -.
DR TRANSFAC; T01529; -.
DR Ensembl; ENSG00000069667; Homo_sapiens
DR Genew; HGNC:10258; RORA.
DR CleanEx; HGNC:10258; RORA.
DR H-InvDB; HIX0012303; -.
DR MIM; 600825; -. [NCBI / EBI]
DR GeneCards; RORA.
DR GeneLynx; RORA.
DR GenAtlas; RORA.
DR SOURCE; RORA.
DR GO; GO:0004879; F:ligand-dependent nuclear receptor activity; TAS.
DR GO; GO:0007165; P:signal transduction; NAS.
DR InterPro; IPR000536; Hrmon_recept_lig.
DR InterPro; IPR001723; Stdhrmn_receptor.
DR InterPro; IPR008946; Str_ncl_receptor.
DR InterPro; IPR001628; Znf_C4steroid.
DR InterPro; Graphical view of domain structure.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR Pfam; Graphical view of domain structure.
DR PRINTS; PR01293; RORNUCRECPTR.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR ProDom; PD000035; Znf_C4steroid; 1.
DR ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR CMR; P35398.
DR HOVERGEN [Family / Alignment / Tree]
DR BLOCKS; P35398.
DR ProtoNet; P35398.
DR ProtoMap; P35398.
DR PRESAGE; P35398.
DR DIP; P35398.
DR ModBase; P35398.
DR SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW 3D-structure; Activator; Alternative splicing; DNA-binding;
KW Nuclear protein; Receptor; Transcription; Transcription regulation;
KW Zinc-finger.
FT DOMAIN 1 105 Modulating.
FT DNA_BIND 106 171 Nuclear receptor-type.
FT ZN_FING 106 126 C4-type.
FT ZN_FING 142 166 C4-type.
FT DOMAIN 172 304 Hinge.
FT DOMAIN 305 556 Ligand-binding.
FT DOMAIN 199 202 Poly-Gln.
FT VARSPLIC 1 99 MNEGAPGDSDLETEARVPWSIMGHCLRTGQARMSATPTPAG
FT EGARRDELFGILQILHQCILSSGDAFVLTGVCCSWRQNGKP
FT PYSQKEDKEVQTGYMNA -> MESAPAAPDPAASEPGSSGA
FT DAAAGSRETPLNQESARKSEPPAPVRRQSYSSTSRGISVTK
FT KTHTS (in isoform Alpha-1).
FT /FTId=VSP_003655.
FT VARSPLIC 46 98 RDELFGILQILHQCILSSGDAFVLTGVCCSWRQNGKPPYSQ
FT KEDKEVQTGYMN -> SSSTCSSLSRLFWSQLEHINWDGAT
FT AKNFINLREFFSFLLPALRK (in isoform Alpha-
FT 3).
FT /FTId=VSP_003656.
FT VARSPLIC 1 98 MNEGAPGDSDLETEARVPWSIMGHCLRTGQARMSATPTPAG
FT EGARRDELFGILQILHQCILSSGDAFVLTGVCCSWRQNGKP
FT PYSQKEDKEVQTGYMN -> MMYFVIAEMK (in
FT isoform Alpha-4).
FT /FTId=VSP_003657.
FT CONFLICT 401 401 M -> V (in Ref. 2).
FT CONFLICT 499 499 I -> M (in Ref. 2).
FT HELIX 304 319
FT TURN 320 320
FT HELIX 325 330
FT TURN 331 333
FT STRAND 335 335
FT HELIX 338 346
FT HELIX 349 373
FT TURN 375 379
FT HELIX 382 400
FT HELIX 401 404
FT STRAND 405 406
FT TURN 407 410
FT STRAND 411 414
FT TURN 415 416
FT STRAND 417 419
FT HELIX 421 427
FT HELIX 430 444
FT TURN 445 446
FT HELIX 450 461
FT TURN 464 465
FT TURN 467 468
FT HELIX 472 493
FT TURN 495 496
FT HELIX 499 527
FT HELIX 529 535
FT HELIX 538 543
SQ SEQUENCE 556 AA; 63036 MW; 0D9797A147CEE8AE CRC64;
MNEGAPGDSD LETEARVPWS IMGHCLRTGQ ARMSATPTPA GEGARRDELF GILQILHQCI
LSSGDAFVLT GVCCSWRQNG KPPYSQKEDK EVQTGYMNAQ IEIIPCKICG DKSSGIHYGV
ITCEGCKGFF RRSQQSNATY SCPRQKNCLI DRTSRNRCQH CRLQKCLAVG MSRDAVKFGR
MSKKQRDSLY AEVQKHRMQQ QQRDHQQQPG EAEPLTPTYN ISANGLTELH DDLSNYIDGH
TPEGSKADSA VSSFYLDIQP SPDQSGLDIN GIKPEPICDY TPASGFFPYC SFTNGETSPT
VSMAELEHLA QNISKSHLET CQYLREELQQ ITWQTFLQEE IENYQNKQRE VMWQLCAIKI
TEAIQYVVEF AKRIDGFMEL CQNDQIVLLK AGSLEVVFIR MCRAFDSQNN TVYFDGKYAS
PDVFKSLGCE DFISFVFEFG KSLCSMHLTE DEIALFSAFV LMSADRSWLQ EKVKIEKLQQ
KIQLALQHVL QKNHREDGIL TKLICKVSTL RALCGRHTEK LMAFKAIYPD IVRLHFPPLY
KELFTSEFEP AMQIDG
//