Swiss-Prot entry

ID   Q9TU02_RABIT PRELIMINARY;      PRT;   411 AA.
AC   Q9TU02;
DT   01-MAY-2000 (TrEMBLrel. 13, Created)
DT   01-MAY-2000 (TrEMBLrel. 13, Last sequence update)
DT   01-FEB-2005 (TrEMBLrel. 29, Last annotation update)
DE   Pregnane x receptor.
GN   Name=NR1I2; Synonyms=PXR;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; 
OC   Mammalia; Eutheria; Lagomorpha; Leporidae; Oryctolagus. 
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=breed New Zealand white rabbit; TISSUE=Kidney;
RX   MEDLINE=20235257; PubMed=10772631 [NCBI, ExPASy, EBI, Israel, Japan];
RA   Savas U., Wester M.R., Griffin K.J., Johnson E.F.;
RT   "Rabbit pregnane X receptor is activated by rifampicin.";
RL   Drug Metab. Dispos. 28:529-537(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=20092326; PubMed=10628745 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1210/me.14.1.27;
RA   Jones S.A., Moore L.B., Shenk J.L., Wisely G.B., Hamilton G.A.,
RA   McKee D.D., Tomkinson N.C., LeCluyse E.L., Lambert M.H., Willson T.M.,
RA   Kliewer S.A., Moore J.T.;
RT   "The pregnane X receptor: a promiscuous xenobiotic receptor that has
RT   diverged during evolution.";
RL   Mol. Endocrinol. 14:27-39(2000).
CC   -!- SUBUNIT: Heterodimer of NR1I3 and RXR (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nuclear (By similarity).
CC   -!- DOMAIN: Composed by a short N-terminal domain followed by the DNA
CC       binding, hinge, and ligand binding/dimerization domains (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
DR   EMBL; AF182217; AAD54426.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   EMBL; AF188476; AAF31165.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   HSSP; O75469; 1NRL. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR   TRANSFAC; T04630; -.
DR   GO; GO:0005634; C:nucleus; IEA.
DR   GO; GO:0003707; F:steroid hormone receptor activity; IEA.
DR   GO; GO:0003700; F:transcription factor activity; IEA.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA.
DR   GO; GO:0006350; P:transcription; IEA.
DR   InterPro; IPR000536; Hrmon_recept_lig.
DR   InterPro; IPR001723; Stdhrmn_receptor.
DR   InterPro; IPR000324; VitD_receptor.
DR   InterPro; IPR001628; Znf_C4steroid.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   PRINTS; PR00350; VITAMINDR.
DR   ProDom; PD000035; Znf_C4steroid; 1.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   PROSITE; PS00031; NUCLEAR_RECEPTOR; 1.
DR   HOVERGEN [Family / Alignment / Tree]
DR   ProtoMap; Q9TU02.
DR   PRESAGE; Q9TU02.
DR   ModBase; Q9TU02.
DR   SMR; Q9TU02.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   Activator; DNA-binding; Metal-binding; Nuclear protein; Receptor;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
SQ   SEQUENCE   411 AA;  47309 MW;  BBF955EC17E2E71A CRC64;
     MGGKPTISAD EEEGPQTCRV CGDKANGYHF NVLTCEGCKG FFRRTVKRNA RLRCPFRKGA
     CEITRKTRRQ CQACRLRKCL ESGMKKEMIM SDVAVAQRRA LIKRKKRERM EAQPPGMQGL
     TGEQRMIIEE LMDAQMKTFD TTFSHFKNFR LPEVLGSGCE IPESLQALTE EEAGRWRQIQ
     EELGTMKLSL QLRGEDGSVW NYTPPADRSG KKLFSLLPHL ADMSTYMFKG IINFAKVISY
     FRDLPIEDQI SLLKGATLEL CLLRFNTVFN AETGTWECGR LSYCVEDPEG GFQQLLVDPL
     LKFHYMLKKL QLHKEEYVLM QAISLFSPDR PGVVQREVVD QLQERFAITL KAYIECSRPQ
     PTHRFLFLKI MAVLTELRTI NAQHTQRLLR IQDTHPFATP LMRELFSTTD D
//