Swiss-Prot entry
ID Q8SQ01_MACMU PRELIMINARY; PRT; 434 AA.
AC Q8SQ01;
DT 01-JUN-2002 (TrEMBLrel. 21, Created)
DT 01-JUN-2002 (TrEMBLrel. 21, Last sequence update)
DT 01-MAR-2004 (TrEMBLrel. 26, Last annotation update)
DE Pregnane X receptor.
GN Name=PXR;
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Primates; Catarrhini; Cercopithecidae;
OC Cercopithecinae; Macaca.
OX NCBI_TaxID=9544;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RX MEDLINE=21977871; PubMed=11981033 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1210/me.16.5.977;
RA Moore L.B., Maglich J.M., McKee D.D., Wisely B., Willson T.M.,
RA Kliewer S.A., Lambert M.H., Moore J.T.;
RT "Pregnane X receptor (PXR), constitutive androstane receptor (CAR),
RT and benzoate X receptor (BXR) define three pharmacologically distinct
RT classes of nuclear receptors.";
RL Mol. Endocrinol. 16:977-986(2002).
CC -!- SUBCELLULAR LOCATION: Nuclear (By similarity).
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
DR EMBL; AF454671; AAM10633.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR HSSP; O75469; 1NRL. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR GO; GO:0005634; C:nucleus; IEA.
DR GO; GO:0003707; F:steroid hormone receptor activity; IEA.
DR GO; GO:0003700; F:transcription factor activity; IEA.
DR GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA.
DR GO; GO:0006350; P:transcription; IEA.
DR InterPro; IPR000536; Hrmon_recept_lig.
DR InterPro; IPR001723; Stdhrmn_receptor.
DR InterPro; IPR000324; VitD_receptor.
DR InterPro; IPR001628; Znf_C4steroid.
DR InterPro; Graphical view of domain structure.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR Pfam; Graphical view of domain structure.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR PRINTS; PR00350; VITAMINDR.
DR ProDom; PD000035; Znf_C4steroid; 1.
DR ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR PROSITE; PS00031; NUCLEAR_RECEPTOR; 1.
DR HOVERGEN [Family / Alignment / Tree]
DR ProtoMap; Q8SQ01.
DR PRESAGE; Q8SQ01.
DR ModBase; Q8SQ01.
DR SMR; Q8SQ01.
DR SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW DNA-binding; Metal-binding; Nuclear protein; Receptor; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
SQ SEQUENCE 434 AA; 49993 MW; F3BE3017815F3A59 CRC64;
MEVRPKEGWN HADFVYCEDT EFAPGKPTVN ADEEVGGPQI CRVCGDKATG YHFNVMTCEG
CKGFFRRAMK RNARLRCPFR KGACEITRKT RRQCQACRLR KCLESGMKKE MIMSDAAVEE
RRALIKRKKR ERIGTQPPGV QGLTEEQRMM IRELMDAQMK TFDTTFSHFK NFRLPGVLSS
GCEMPESLQA PSREEAAKWN QVRKDLWSVK VSVQLRGEDG SVWNYKPPAD NGGKEIFSLL
PHMADMSTYM FKGIINFAKV ISYFRDLPIE DQISLLKGAT FELCQLRFNT VFNAETGTWE
CGRLSYCLED PAGGFQQLLL EPMLKFHYML KKLQLHEEEY VLMQAISLFS PDRPGVVQHR
VVDQLQEQYA ITLKSYIECN RPQPAHRFLF LKIMAMLTEL RSINAQHTQR LLRIQDIHPF
ATPLMQELFG ITGS
//