Swiss-Prot entry

ID   Q8MXE5_CAEEL PRELIMINARY;      PRT;   242 AA.
AC   Q8MXE5;
DT   01-OCT-2002 (TrEMBLrel. 22, Created)
DT   01-OCT-2002 (TrEMBLrel. 22, Last sequence update)
DT   01-MAR-2004 (TrEMBLrel. 26, Last annotation update)
DE   Nuclear hormone receptor family protein 104, isoform b.
GN   Name=nhr-104; ORFNames=R11E3.5;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; 
OC   Rhabditidae; Peloderinae; Caenorhabditis. 
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Bristol N2;
RX   MEDLINE=99069613; PubMed=9851916 [NCBI, ExPASy, EBI, Israel, Japan];
RG   WormBase Consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology. The C. elegans Sequencing Consortium.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Bristol N2;
RA   Langston Z., Wohldmann P.;
RT   "The sequence of C. elegans cosmid R11E3.";
RL   Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Bristol N2;
RA   Waterston R.;
RL   Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Bristol N2;
RG   WormBase Consortium;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Receptor for both mineralocorticoids (MC) such as
CC       aldosterone and glucocorticoids (GC) such as corticosterone or
CC       cortisol. Binds to mineralocorticoid response elements (MRE) and
CC       transactivates target genes. The effect of MC is to increase ion
CC       and water transport and thus raise extracellular fluid volume and
CC       blood pressure and lower potassium levels (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nuclear (By similarity).
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
DR   EMBL; AF100669; AAM97937.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   HSSP; O95718; 1LO1. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR   Ensembl; R11E3.5; Caenorhabditis elegans. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   WormBase; WBGene00003694; R11E3.5.
DR   WormPep; R11E3.5b; CE31720. [WormPep / WormBase / WorfDB]
DR   GO; GO:0005634; C:nucleus; IEA.
DR   GO; GO:0003707; F:steroid hormone receptor activity; IEA.
DR   GO; GO:0003700; F:transcription factor activity; IEA.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA.
DR   GO; GO:0006350; P:transcription; IEA.
DR   InterPro; IPR000536; Hrmon_recept_lig.
DR   InterPro; IPR000324; VitD_receptor.
DR   InterPro; IPR001628; Znf_C4steroid.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR00047; STROIDFINGER.
DR   PRINTS; PR00350; VITAMINDR.
DR   SMART; SM00399; ZnF_C4; 1.
DR   CMR; Q8MXE5.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain]
DR   ProtoMap; Q8MXE5.
DR   PRESAGE; Q8MXE5.
DR   ModBase; Q8MXE5.
DR   SMR; Q8MXE5.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   DNA-binding; Metal-binding; Nuclear protein; Receptor; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
SQ   SEQUENCE   242 AA;  28206 MW;  DA585997F2E7A585 CRC64;
     MRFNPCDVCL SPGNGKHFGV DACRGCTAFF RRTIVNKRNY SCSEDDTCEI EKSEGLLCKK
     CRFEKCLKVG MKKESIQKHR DIYGRRNPEN RALIISPSTS QLQVTIPITL LSSVKRNYAE
     LENVREIVHR MDGFSMFLKP APRGQTYKET YRLLLREFYL VSDWVSNCFP LFKELPNSQK
     DILLRNFYLT FYNLEAGFFA CQHNKIDVWF LPNGNFIDCQ NLEAFYYDPH NQQPMTSADA
     AR
//