Swiss-Prot entry

ID   Q8MHZ0_MACFA PRELIMINARY;      PRT;   483 AA.
AC   Q8MHZ0;
DT   01-OCT-2002 (TrEMBLrel. 22, Created)
DT   01-OCT-2002 (TrEMBLrel. 22, Last sequence update)
DT   01-FEB-2005 (TrEMBLrel. 29, Last annotation update)
DE   Peroxisome proliferator-activated receptor gamma 4 (Peroxisome
DE   proliferator-activated receptor gamma 6).
GN   Name=PPARgamma4; Synonyms=PPARgamma6;
OS   Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; 
OC   Mammalia; Eutheria; Primates; Catarrhini; Cercopithecidae; 
OC   Cercopithecinae; Macaca. 
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=22050014; PubMed=12054596 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1016/S0006-291X(02)00138-9;
RA   Zhou J., Wilson K.M., Medh J.D.;
RT   "Genetic analysis of four novel peroxisome proliferator activated
RT   receptor-gamma splice variants in monkey macrophages.";
RL   Biochem. Biophys. Res. Commun. 293:274-283(2002).
CC   -!- FUNCTION: Receptor that binds peroxisome proliferators such as
CC       hypolipidemic drugs and fatty acids. Once activated by a ligand,
CC       the receptor binds to a promoter element in the gene for acyl-CoA
CC       oxidase and activates its transcription. It therefore controls the
CC       peroxisomal beta-oxidation pathway of fatty acids. Key regulator
CC       of adipocyte differentiation and glucose homeostasis (By
CC       similarity).
CC   -!- SUBUNIT: Forms a heterodimer with the retinoic acid receptor RXR-
CC       alpha called adipocyte-specific transcription factor ARF6.
CC       Interacts with NCOA6 coactivator, leading to a strong increase in
CC       transcription of target genes (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nuclear (By similarity).
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
DR   EMBL; AY048697; AAL05267.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   EMBL; AY048699; AAL05269.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   HSSP; Q96J12; 1FM9. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR   GO; GO:0005634; C:nucleus; IEA.
DR   GO; GO:0003707; F:steroid hormone receptor activity; IEA.
DR   GO; GO:0003700; F:transcription factor activity; IEA.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA.
DR   GO; GO:0006350; P:transcription; IEA.
DR   InterPro; IPR003074; 1Cnucl_receptor.
DR   InterPro; IPR003077; 1Cnucl_receptorG.
DR   InterPro; IPR000536; Hrmon_recept_lig.
DR   InterPro; IPR001723; Stdhrmn_receptor.
DR   InterPro; IPR001628; Znf_C4steroid.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR01288; PROXISOMEPAR.
DR   PRINTS; PR01291; PROXISOMPAGR.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   ProDom; PD000035; Znf_C4steroid; 1.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   PROSITE; PS00031; NUCLEAR_RECEPTOR; 1.
DR   HOVERGEN [Family / Alignment / Tree]
DR   ProtoMap; Q8MHZ0.
DR   PRESAGE; Q8MHZ0.
DR   ModBase; Q8MHZ0.
DR   SMR; Q8MHZ0.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   DNA-binding; Metal-binding; Nuclear protein; Receptor; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
SQ   SEQUENCE   483 AA;  55364 MW;  56BE85B9A2BAB1FF CRC64;
     MKGFSEITMV DTEMPFWPTN FGISSVDLSV MDDHSHSFDI KPFTTVDFSS ISAPHYEDIP
     FTRTDPMVAD YKYDLKLQEY QSAIKVEPAS PPYYSEKTQL YNKPHEEPSN SLMAIECRVC
     GDKASGFHYG VHACEGCKGF FRRTIRLKLI YDRCDLNCRI HKKSRNKCQY CRFQKCLAVG
     MSHNAIRFGR MPQAEKEKLL AEISSDIDQL NPESADLRAL AKHLYDSYIK SFPLTKAKAR
     AILTGKTTDK SPFVIYDMNS LMMGEDKIKF KHITPLQEQS KEVAIRIFQG CQFRSVEAVQ
     EITEYAKSIP GFVNLDLNDQ VTLLKYGVHE IIYTMLASLM NKDGVFISEG QGFMTREFLK
     SLRKPFGDFM EPKFEFAVKF NALELDDSDL AIFIAVIILS GDRPGLLNVK PIEDIQDNLL
     QALELQLKLN HPESSQLFAK LLQKMTDLRQ IVTEHVQLLQ VIKKTETDMS LHPLLQEIYK
     DLY
//