Swiss-Prot entry
ID Q8AXB6_BRARE PRELIMINARY; PRT; 454 AA.
AC Q8AXB6;
DT 01-MAR-2003 (TrEMBLrel. 23, Created)
DT 01-MAR-2003 (TrEMBLrel. 23, Last sequence update)
DT 01-MAR-2004 (TrEMBLrel. 26, Last annotation update)
DE Hepatocyte nuclear factor 4 alpha.
GN Name=hnf4a;
OS Brachydanio rerio (Zebrafish) (Danio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Liver;
RA Gong H.Y., Lin C.J.F., Wu J.L.;
RL Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nuclear (By similarity).
CC -!- DOMAIN: Composed of three domains: a modulating N-terminal domain,
CC a DNA-binding domain and a C-terminal steroid-binding domain (By
CC similarity).
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
DR EMBL; AF473824; AAN77281.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR HSSP; P22449; 1M7W. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR ZFIN; ZDB-GENE-030131-1077; hnf4a.
DR GO; GO:0005634; C:nucleus; IEA.
DR GO; GO:0005496; F:steroid binding; IEA.
DR GO; GO:0003707; F:steroid hormone receptor activity; IEA.
DR GO; GO:0003700; F:transcription factor activity; IEA.
DR GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA.
DR GO; GO:0006350; P:transcription; IEA.
DR InterPro; IPR000536; Hrmon_recept_lig.
DR InterPro; IPR000003; RtnoidX_receptor.
DR InterPro; IPR001723; Stdhrmn_receptor.
DR InterPro; IPR001628; Znf_C4steroid.
DR InterPro; Graphical view of domain structure.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR Pfam; Graphical view of domain structure.
DR PRINTS; PR00545; RETINOIDXR.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR ProDom; PD000035; Znf_C4steroid; 1.
DR ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR PROSITE; PS00031; NUCLEAR_RECEPTOR; 1.
DR CMR; Q8AXB6.
DR HOVERGEN [Family / Alignment / Tree]
DR ProtoMap; Q8AXB6.
DR PRESAGE; Q8AXB6.
DR ModBase; Q8AXB6.
DR SMR; Q8AXB6.
DR SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW DNA-binding; Metal-binding; Nuclear protein; Receptor; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
SQ SEQUENCE 454 AA; 50721 MW; 32B10D23A593AF52 CRC64;
MEMADYSEAL DPAYTTLEFE NMQVLAMSTD SSPQESANMN AANHLGAGTL CAICGDRATG
KHYGASSCDG CKGFFRRSVR KNHMYSCRFN RQCIVDKDKR NQCRYCRLKK CFRAGMKKEA
VQNERDRIST RRSSYEDSSL PSINALIQAD VLSRQISSPG PILNGDIRTK KVAAIMDVCE
SMKQQLLVLV EWAKYIPAFC DLPLDDQVAL LRAHAGEHLL LGAAKRSMMY KDILLLGNDH
IIPRNCPELE VSRVAVRILD ELVLPFQDLQ IDDNEYACLK AIVFFDPDAK GLSDPSKIKR
MRYQVQVSLE DYINDRQYDS RGRFGELLLL LPTLQSITWQ MIEQIQFVKL FGMAKIDNLL
QEMLLGGSAN EAPHAHHSLH PHLVQEHLSN NVIVTANMAT PLHNGQMSTP ETPIPSPPTA
SGSDHYKMAS GVIATVPKQP SSIPQPTITK QEAI
//