Swiss-Prot entry

ID   Q86WD1_HUMAN PRELIMINARY;      PRT;   584 AA.
AC   Q86WD1;
DT   01-JUN-2003 (TrEMBLrel. 24, Created)
DT   01-JUN-2003 (TrEMBLrel. 24, Last sequence update)
DT   01-MAR-2004 (TrEMBLrel. 26, Last annotation update)
DE   CREB3L2-PPARgamma.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; 
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. 
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RA   Lui W.-O., Leibiger I., Leibiger B., Thoppe S., Enberg U., Liden J.,
RA   Hoog A., Farnebo L.-O., Fletcher J.A., Kroll T.G., Larsson C.;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Receptor that binds peroxisome proliferators such as
CC       hypolipidemic drugs and fatty acids. Once activated by a ligand,
CC       the receptor binds to a promoter element in the gene for acyl-CoA
CC       oxidase and activates its transcription. It therefore controls the
CC       peroxisomal beta-oxidation pathway of fatty acids. Key regulator
CC       of adipocyte differentiation and glucose homeostasis (By
CC       similarity).
CC   -!- SUBUNIT: Forms a heterodimer with the retinoic acid receptor RXR-
CC       alpha called adipocyte-specific transcription factor ARF6.
CC       Interacts with NCOA6 coactivator, leading to a strong increase in
CC       transcription of target genes (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nuclear (By similarity).
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
DR   EMBL; AY222643; AAO66458.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   HSSP; Q96J12; 1FM9. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR   GO; GO:0005634; C:nucleus; IEA.
DR   GO; GO:0003707; F:steroid hormone receptor activity; IEA.
DR   GO; GO:0003700; F:transcription factor activity; IEA.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA.
DR   GO; GO:0006350; P:transcription; IEA.
DR   InterPro; IPR003074; 1Cnucl_receptor.
DR   InterPro; IPR003077; 1Cnucl_receptorG.
DR   InterPro; IPR000536; Hrmon_recept_lig.
DR   InterPro; IPR001723; Stdhrmn_receptor.
DR   InterPro; IPR001628; Znf_C4steroid.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR01288; PROXISOMEPAR.
DR   PRINTS; PR01291; PROXISOMPAGR.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   ProDom; PD000035; Znf_C4steroid; 1.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   PROSITE; PS00031; NUCLEAR_RECEPTOR; 1.
DR   HOVERGEN [Family / Alignment / Tree]
DR   ProtoMap; Q86WD1.
DR   PRESAGE; Q86WD1.
DR   ModBase; Q86WD1.
DR   SMR; Q86WD1.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   DNA-binding; Metal-binding; Nuclear protein; Receptor; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
SQ   SEQUENCE   584 AA;  66633 MW;  48D57239C8B3BD94 CRC64;
     MEVLESGEQG VLQWDRKLSE LSEPGDGEAL MYHTHFSELL DEFSQNVLGQ LLNDPFLSEK
     SVSMEVEPSP TSPAPLIQAE HSYSLCEEPR AQSPFTHITT SDSFNDEMTM VDTEMPFWPT
     NFGISSVDLS VMEDHSHSFD IKPFTTVDFS SISTPHYEDI PFTRTDPVVA DYKYDLKLQE
     YQSAIKVEPA SPPYYSEKTQ LYNKPHEEPS NSLMAIECRV CGDKASGFHY GVHACEGCKG
     FFRRTIRLKL IYDRCDLNCR IHKKSRNKCQ YCRFQKCLAV GMSHNAIRFG RMPQAEKEKL
     LAEISSDIDQ LNPESADLRA LAKHLYDSYI KSFPLTKAKA RAILTGKTTD KSPFVIYDMN
     SLMMGEDKIK FKHITPLQEQ SKEVAIRIFQ GCQFRSVEAV QEITEYAKSI PGFVNLDLND
     QVTLLKYGVH EIIYTMLASL MNKDGVLISE GQGFMTREFL KSLRKPFGDF MEPKFEFAVK
     FNALELDDSD LAIFIAVIIL SGDRPGLLNV KPIEDIQDNL LQALELQLKL NHPESSQLFA
     KLLQKMTDLR QIVTEHVQLL QVIKKTETDM SLHPLLQEIY KDLY
//