Swiss-Prot entry
ID Q866S0_CAPHI PRELIMINARY; PRT; 475 AA.
AC Q866S0;
DT 01-JUN-2003 (TrEMBLrel. 24, Created)
DT 01-JUN-2003 (TrEMBLrel. 24, Last sequence update)
DT 01-MAR-2004 (TrEMBLrel. 26, Last annotation update)
DE Proliferator activated receptor-gamma1.
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RA Khoo B.Y., Samian R., Najimudin N., Tengku Muhammad T.S.;
RL Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor that binds peroxisome proliferators such as
CC hypolipidemic drugs and fatty acids. Once activated by a ligand,
CC the receptor binds to a promoter element in the gene for acyl-CoA
CC oxidase and activates its transcription. It therefore controls the
CC peroxisomal beta-oxidation pathway of fatty acids. Key regulator
CC of adipocyte differentiation and glucose homeostasis (By
CC similarity).
CC -!- SUBUNIT: Forms a heterodimer with the retinoic acid receptor RXR-
CC alpha called adipocyte-specific transcription factor ARF6.
CC Interacts with NCOA6 coactivator, leading to a strong increase in
CC transcription of target genes (By similarity).
CC -!- SUBCELLULAR LOCATION: Nuclear (By similarity).
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
DR EMBL; AY178574; AAO19445.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR HSSP; Q96J12; 2PRG. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR GO; GO:0005634; C:nucleus; IEA.
DR GO; GO:0003707; F:steroid hormone receptor activity; IEA.
DR GO; GO:0003700; F:transcription factor activity; IEA.
DR GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA.
DR GO; GO:0006350; P:transcription; IEA.
DR InterPro; IPR003074; 1Cnucl_receptor.
DR InterPro; IPR003077; 1Cnucl_receptorG.
DR InterPro; IPR000536; Hrmon_recept_lig.
DR InterPro; IPR001723; Stdhrmn_receptor.
DR InterPro; IPR001628; Znf_C4steroid.
DR InterPro; Graphical view of domain structure.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR Pfam; Graphical view of domain structure.
DR PRINTS; PR01288; PROXISOMEPAR.
DR PRINTS; PR01291; PROXISOMPAGR.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR ProDom; PD000035; Znf_C4steroid; 1.
DR ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR PROSITE; PS00031; NUCLEAR_RECEPTOR; 1.
DR HOVERGEN [Family / Alignment / Tree]
DR ProtoMap; Q866S0.
DR PRESAGE; Q866S0.
DR ModBase; Q866S0.
DR SMR; Q866S0.
DR SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW DNA-binding; Metal-binding; Nuclear protein; Receptor; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
SQ SEQUENCE 475 AA; 54478 MW; F18D7C387FEFCB63 CRC64;
MVDTEMPFWP TNFGISSVDL SMMDDHSHAF DIKPFTTVDF SSISAPHYED IPFPRADPMV
ADYKYDLKLQ EYQSAIKVEP VSPPYYSEKT QLYSKPHEEP SNSLMAIECR VCGDKASGFH
YGVHACEGCK GFFRRTIRLK LIYDRCDLYC RIHKKSRNKC QYCRFQKCLA VGMSHNAIRF
GRMPQAEKEK LLAEISSDID QLNPESADLR ALAKHLYDSY IKSFPLTRAK ARAILTGKTT
DKSPFVIYDM NSLMMGEDKI KFKHISPLQE PSKEVAIRIF QGCQFRSVEA VQEITEYAKN
IPGFVNLDLN DQVTLLKYGV HEIIYTMLAS LMNKDGVLIS EGQGFMTREF LKSLRKPFGD
FMEPKFEFAV KFNALELDDS DLAIFIAVII LSGDRPGLLN VKPIEDIQDN LLQALELQLK
LNHPESSQLF AKLLQKMTDL RQIVTEHVQL LQVIKKTETD MSLHPLLQEI YKDLY
//