Swiss-Prot entry
ID Q866Q2_PIG PRELIMINARY; PRT; 441 AA.
AC Q866Q2;
DT 01-JUN-2003 (TrEMBLrel. 24, Created)
DT 01-JUN-2003 (TrEMBLrel. 24, Last sequence update)
DT 01-MAR-2004 (TrEMBLrel. 26, Last annotation update)
DE Peroxisome proliferator-activated receptor delta.
GN Name=PPARd;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Cetartiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Uterus;
RA Palin M.F., Beaudry D., Murphy B.D., Downey B.R.;
RL Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor that binds peroxisome proliferators such as
CC hypolipidemic drugs and fatty acids. Once activated by a ligand,
CC the receptor binds to a promoter element in the gene for acyl-CoA
CC oxidase and activates its transcription. It therefore controls the
CC peroxisomal beta-oxidation pathway of fatty acids (By similarity).
CC -!- SUBUNIT: Heterodimer with the retinoid X receptor (By similarity).
CC -!- SUBCELLULAR LOCATION: Nuclear (By similarity).
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
DR EMBL; AY188501; AAO34393.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR HSSP; Q96J12; 1I7I. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR GO; GO:0005634; C:nucleus; IEA.
DR GO; GO:0003707; F:steroid hormone receptor activity; IEA.
DR GO; GO:0003700; F:transcription factor activity; IEA.
DR GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA.
DR GO; GO:0006350; P:transcription; IEA.
DR InterPro; IPR003074; 1Cnucl_receptor.
DR InterPro; IPR003075; 1Cnucl_receptorB.
DR InterPro; IPR000536; Hrmon_recept_lig.
DR InterPro; IPR001723; Stdhrmn_receptor.
DR InterPro; IPR001628; Znf_C4steroid.
DR InterPro; Graphical view of domain structure.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR Pfam; Graphical view of domain structure.
DR PRINTS; PR01288; PROXISOMEPAR.
DR PRINTS; PR01290; PROXISOMPABR.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR ProDom; PD000035; Znf_C4steroid; 1.
DR ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR PROSITE; PS00031; NUCLEAR_RECEPTOR; 1.
DR HOVERGEN [Family / Alignment / Tree]
DR ProtoMap; Q866Q2.
DR PRESAGE; Q866Q2.
DR ModBase; Q866Q2.
DR SMR; Q866Q2.
DR SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW DNA-binding; Metal-binding; Nuclear protein; Receptor; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
SQ SEQUENCE 441 AA; 49773 MW; 2D5B4B8E1420A523 CRC64;
MEQPPEEAPE VREEEKKKEV AEAEGGPELN GGPEHSLPSS SCTDLSQSCS PPALLDQLQM
GCDGASCGGL SMECRVCGDK ASGFHYGVHA CEGCKGFFRR TIRMKLEYEK CERICKIQKK
NRNKCQYCRF QKCLALGMSH NAIRFGRMPE AEKRKLVAGL TANEGSQHNP QVADLKAFSK
HLYSAYLKNF NMTKKKARAI LTGKASHTAP FVIHDIETLW QAEKGLVWKQ LVNGLPPYKE
ISVHVFYRCQ CTTVETVREL TEFAKSIPSF DHFFLNDQVT LLKYGVHEAI FAMLASIVNK
DGLLVANGTG FVTREFLRSI RKPFSDIIEP KFEFAVKFNA LELDDSDLAL FIAAIILCGD
RPGLMNVSQV EAIQDTILRA LEFHLQANHP DAQYLFPKLL QKMADLRQLV TEHAQMMQRI
KKTETETSLH PLLQEIYKDM Y
//