Swiss-Prot entry

ID   Q7SIF6_HELVI PRELIMINARY;      PRT;   264 AA.
AC   Q7SIF6;
DT   01-MAR-2004 (TrEMBLrel. 26, Created)
DT   01-MAR-2004 (TrEMBLrel. 26, Last sequence update)
DT   01-MAR-2004 (TrEMBLrel. 26, Last annotation update)
DE   Gene regulation protein.
OS   Heliothis virescens (Noctuid moth) (Owlet moth).
OC   Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; 
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea; 
OC   Noctuidae; Heliothinae; Heliothis. 
OX   NCBI_TaxID=7102;
RN   [1]
RP   X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS).
RX   PubMed=11053444 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1074/jbc.M008926200;
RA   Billas I.M., Moulinier L., Rochel N., Moras D.;
RT   "Crystal structure of the ligand-binding domain of the ultraspiracle
RT   protein USP, the ortholog of retinoid X receptors in insects.";
RL   J. Biol. Chem. 276:7465-7474(2001).
CC   -!- FUNCTION: Receptor for both mineralocorticoids (MC) such as
CC       aldosterone and glucocorticoids (GC) such as corticosterone or
CC       cortisol. Binds to mineralocorticoid response elements (MRE) and
CC       transactivates target genes. The effect of MC is to increase ion
CC       and water transport and thus raise extracellular fluid volume and
CC       blood pressure and lower potassium levels (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nuclear (By similarity).
DR   PDB; 1G2N; X-ray; A=1-264. [ExPASy / RCSB]
DR   PDB; 1R1K; X-ray; A=2-264. [ExPASy / RCSB]
DR   PDB; 1R20; X-ray; A=2-264. [ExPASy / RCSB]
DR   GO; GO:0005634; C:nucleus; IEA.
DR   GO; GO:0003707; F:steroid hormone receptor activity; IEA.
DR   GO; GO:0003700; F:transcription factor activity; IEA.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA.
DR   InterPro; IPR000536; Hrmon_recept_lig.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; Graphical view of domain structure.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain]
DR   ProtoMap; Q7SIF6.
DR   PRESAGE; Q7SIF6.
DR   ModBase; Q7SIF6.
DR   SMR; Q7SIF6.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   3D-structure; Nuclear protein; Transcription regulation.
SQ   SEQUENCE   264 AA;  29927 MW;  74C01A01F8F096ED CRC64;
     AAVQELSIER LLEMESLVAD PSEEFQFLRV GPDSNVPPKF RAPVSSLCQI GNKQIAALVV
     WARDIPHFSQ LEMEDQILLI KGSWNELLLF AIAWRSMEFL TEERDGVDGT GNRTTSPPQL
     MCLMPGMTLH RNSALQAGVG QIFDRVLSEL SLKMRTLRVD QAEYVALKAI ILLNPDVKGL
     KNRQEVEVLR EKMFLCLDEY CRRSRSSEEG RFAALLLRLP ALRSISLKSF EHLFFFHLVA
     DTSIAGYIRD ALRNHAPPID TNMM
//