Swiss-Prot entry

ID   Q6AXA9_XENLA PRELIMINARY;      PRT;   474 AA.
AC   Q6AXA9;
DT   25-OCT-2004 (TrEMBLrel. 28, Created)
DT   25-OCT-2004 (TrEMBLrel. 28, Last sequence update)
DT   25-OCT-2004 (TrEMBLrel. 28, Last annotation update)
DE   Hypothetical protein.
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; 
OC   Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae; 
OC   Xenopodinae; Xenopus. 
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Ovary;
RX   MEDLINE=22341132; PubMed=12454917 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1002/dvdy.10174;
RA   Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA   Richardson P.;
RT   "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT   initiative.";
RL   Dev. Dyn. 225:384-391(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Ovary;
RX   PubMed=12477932 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1073/pnas.242603899;
RA   Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G.,
RA   Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D.,
RA   Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K.,
RA   Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F.,
RA   Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L.,
RA   Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E.,
RA   Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C.,
RA   Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J.,
RA   Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H.,
RA   Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W.,
RA   Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A.,
RA   Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A.,
RA   Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA   Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C.,
RA   Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S.,
RA   Krzywinski M.I., Skalska U., Smailus D.E., Schnerch A., Schein J.E.,
RA   Jones S.J., Marra M.A.;
RT   "Generation and initial analysis of more than 15,000 full-length human
RT   and mouse cDNA sequences.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Ovary;
RA   Klein S., Gerhard D.S.;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Receptor that binds peroxisome proliferators such as
CC       hypolipidemic drugs and fatty acids. Once activated by a ligand,
CC       the receptor binds to a promoter element in the gene for acyl-CoA
CC       oxidase and activates its transcription. It therefore controls the
CC       peroxisomal beta-oxidation pathway of fatty acids (By similarity).
CC   -!- SUBUNIT: Heterodimer with the retinoid X receptor (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nuclear (By similarity).
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
DR   EMBL; BC079684; AAH79684.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   GO; GO:0005634; C:nucleus; IEA.
DR   GO; GO:0003707; F:steroid hormone receptor activity; IEA.
DR   GO; GO:0003700; F:transcription factor activity; IEA.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA.
DR   GO; GO:0006350; P:transcription; IEA.
DR   InterPro; IPR003074; 1Cnucl_receptor.
DR   InterPro; IPR003076; 1Cnucl_receptorA.
DR   InterPro; IPR000536; Hrmon_recept_lig.
DR   InterPro; IPR001723; Stdhrmn_receptor.
DR   InterPro; IPR001628; Znf_C4steroid.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR01288; PROXISOMEPAR.
DR   PRINTS; PR01289; PROXISOMPAAR.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   ProDom; PD000035; Znf_C4steroid; 1.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   PROSITE; PS00031; NUCLEAR_RECEPTOR; 1.
DR   HOVERGEN [Family / Alignment / Tree]
DR   ProtoMap; Q6AXA9.
DR   PRESAGE; Q6AXA9.
DR   ModBase; Q6AXA9.
DR   SMR; Q6AXA9.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   DNA-binding; Hypothetical protein; Metal-binding; Nuclear protein;
KW   Receptor; Transcription; Transcription regulation; Zinc; Zinc-finger.
SQ   SEQUENCE   474 AA;  52869 MW;  4DB9E43418D59FF4 CRC64;
     MSTIMVDTNS ELCILTPLDE DDLESPLSGE FLQDIVDIQD ITQTIGDDGS TPFGASEHQF
     FGNSPGSIGS VSTDLTDTLS PASSPASITF PAASGSAEDA ACKSLNLECR VCSDKASGFH
     YGVHACEGCK GFFRRTIRLK LVYDRCERMC KIQKKNRNKC QYCRFEKCLN VGMSHNAIRF
     GRMPRSEKAK LKAEVLMCDQ DVKDTQMADL LSLARLIYDA YLKNFNMNKV KARAILTGKA
     SNPPFVIHDM ETLCMAEKTL VAKLVANGIQ NKEAEVRIFH CCQCTSVETV TELTEFAKSI
     PGFTELDLND QVTLLKYGVY EAMFAMLASV MNKDGMLVAY GNGFITREFL KSLRKPIGDM
     MEPKFEFAMK FNALELDDSD LSLFVAALIC CGDRPGLVNI PSIEKMQESI VHVLKLHLQS
     NHPDDSFLFP KLLQKMADLR QLVTEHAQLV QTIKKTETDA ALHPLLQEIY RDMY
//