Swiss-Prot entry
ID Q62879_RAT PRELIMINARY; PRT; 440 AA.
AC Q62879;
DT 01-NOV-1996 (TrEMBLrel. 01, Created)
DT 01-NOV-1996 (TrEMBLrel. 01, Last sequence update)
DT 01-MAR-2004 (TrEMBLrel. 26, Last annotation update)
DE PPAR delta protein.
GN Name=Ppard; Synonyms=PPAR delta;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Sprague Dawley; TISSUE=Brain;
RX MEDLINE=96125342; PubMed=8554552 [NCBI, ExPASy, EBI, Israel, Japan];
RA Xing G., Zhang L., Zhang L., Heynen T., Yoshikawa T., Smith M.,
RA Weiss S., Detera-Wadleigh S.;
RT "Rat PPAR delta contains a CGG triplet repeat and is prominently
RT expressed in the thalamic nuclei.";
RL Biochem. Biophys. Res. Commun. 217:1015-1025(1995).
CC -!- FUNCTION: Receptor that binds peroxisome proliferators such as
CC hypolipidemic drugs and fatty acids. Once activated by a ligand,
CC the receptor binds to a promoter element in the gene for acyl-CoA
CC oxidase and activates its transcription. It therefore controls the
CC peroxisomal beta-oxidation pathway of fatty acids (By similarity).
CC -!- SUBUNIT: Heterodimer with the retinoid X receptor (By similarity).
CC -!- SUBCELLULAR LOCATION: Nuclear (By similarity).
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
DR EMBL; U40064; AAC52419.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR PIR; JC4530; JC4530.
DR HSSP; Q03181; 3GWX. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR Ensembl; ENSRNOG00000000503; Rattus norvegicus. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR RGD; 3370; Ppard.
DR GO; GO:0005634; C:nucleus; IEA.
DR GO; GO:0003707; F:steroid hormone receptor activity; IEA.
DR GO; GO:0003700; F:transcription factor activity; IEA.
DR GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA.
DR GO; GO:0006350; P:transcription; IEA.
DR InterPro; IPR003074; 1Cnucl_receptor.
DR InterPro; IPR003075; 1Cnucl_receptorB.
DR InterPro; IPR000536; Hrmon_recept_lig.
DR InterPro; IPR001723; Stdhrmn_receptor.
DR InterPro; IPR001628; Znf_C4steroid.
DR InterPro; Graphical view of domain structure.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR Pfam; Graphical view of domain structure.
DR PRINTS; PR01288; PROXISOMEPAR.
DR PRINTS; PR01290; PROXISOMPABR.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR ProDom; PD000035; Znf_C4steroid; 1.
DR ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR PROSITE; PS00031; NUCLEAR_RECEPTOR; 1.
DR CMR; Q62879.
DR HOVERGEN [Family / Alignment / Tree]
DR ProtoMap; Q62879.
DR PRESAGE; Q62879.
DR ModBase; Q62879.
DR SMR; Q62879.
DR SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW DNA-binding; Metal-binding; Nuclear protein; Receptor; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
SQ SEQUENCE 440 AA; 49659 MW; 6C366A45D04AB60D CRC64;
MEQPQEETPE AREEEKEEVA TGDGAPELNG GPEHTLPSSS CTDLSQNSSP SSLLDQLQMG
CDGASGGSLN MECRVCGDKA SGFHYGVHAC EGCKGFFRRT IRMKLKYEKC DRICKIQKKN
RNKCQYCRFQ KCLALGMSHN AIRFGRMPEA EKRKLVAGLT ASEGCQQNPQ LADLKAFSKH
IYNAYLKNFN MTKKKARSIL TGKSSHNAPF IIHDIETLWQ AEKGLVWKQL VNGPPPYNEI
SVHVFYRCQS TTVETVRELT EFAKNIPNFS SLFLNDQVTL LKYGVHEAIF AMLASIVNKD
GLLVANGSGF VTHEFLRSIR KPFSDIIEPK FEFAVKFNAL ELVDSDLALF IAAIILCGDR
PGLMNVPQVE AIQDTILQAL EFHLQVNHPD SQYLFPKLLQ KMADLRQLVT EHAQMMQWLK
KTESETLLHP LLQEIYKDMY
//