Swiss-Prot entry

ID   Q22298_CAEEL PRELIMINARY;      PRT;   334 AA.
AC   Q22298;
DT   01-NOV-1996 (TrEMBLrel. 01, Created)
DT   01-NOV-1996 (TrEMBLrel. 01, Last sequence update)
DT   01-MAR-2004 (TrEMBLrel. 26, Last annotation update)
DE   Hypothetical protein T07C5.2.
GN   ORFNames=T07C5.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; 
OC   Rhabditidae; Peloderinae; Caenorhabditis. 
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Bristol N2;
RX   MEDLINE=99069613; PubMed=9851916 [NCBI, ExPASy, EBI, Israel, Japan];
RA   none;
RT   "Genome sequence of the nematode C.elegans: A platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Bristol N2;
RA   McMurray A.A.;
RL   Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Receptor for both mineralocorticoids (MC) such as
CC       aldosterone and glucocorticoids (GC) such as corticosterone or
CC       cortisol. Binds to mineralocorticoid response elements (MRE) and
CC       transactivates target genes. The effect of MC is to increase ion
CC       and water transport and thus raise extracellular fluid volume and
CC       blood pressure and lower potassium levels (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nuclear (By similarity).
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
DR   EMBL; Z50006; CAA90299.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   PIR; T24650; T24650.
DR   HSSP; P20393; 1A6Y. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR   Ensembl; T07C5.2; Caenorhabditis elegans. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   WormBase; WBGene00011565; T07C5.2.
DR   WormPep; T07C5.2; CE06380. [WormPep / WormBase / WorfDB]
DR   GO; GO:0005634; C:nucleus; IEA.
DR   GO; GO:0004872; F:receptor activity; IEA.
DR   GO; GO:0003707; F:steroid hormone receptor activity; IEA.
DR   GO; GO:0003700; F:transcription factor activity; IEA.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA.
DR   GO; GO:0006350; P:transcription; IEA.
DR   InterPro; IPR000536; Hrmon_recept_lig.
DR   InterPro; IPR001628; Znf_C4steroid.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   CMR; Q22298.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain]
DR   ProtoMap; Q22298.
DR   PRESAGE; Q22298.
DR   ModBase; Q22298.
DR   SMR; Q22298.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   DNA-binding; Hypothetical protein; Metal-binding; Nuclear protein;
KW   Receptor; Transcription; Transcription regulation; Zinc; Zinc-finger.
SQ   SEQUENCE   334 AA;  38861 MW;  56258FFCD5DE030D CRC64;
     MTNFGDCVVC GVSTHLFKYG KYLCNSCDLF FRRSMTPWSF FGDCKHNWDC YKESSNRQRL
     PKCRHCRFNK CVDVGLLTVS RYTKLADLVE YLSLLDANRE KTFLKLSIST DFDTNTFLDE
     NPIRFIKKTS DLNFDCDEWQ IMNKLSTIEM LKNLDFPKYL SSQDLRYFLK KGYFLKGILT
     MAMRSYLNQE EFMSFPNGVD LFPDHAREGL HINISFLNLI RCQLVGKFIE LKITREEISM
     LGAIAVSNPA VPDLSSNGQK LLSCYQQLYT SSLLQYCLAK YQQNGPARFC NIMSVLNVAN
     QTYDNIIKYV CLCQYYHSDM QPSKLYQSVL NQLN
//