Swiss-Prot entry

ID   Q18896_CAEEL PRELIMINARY;      PRT;   363 AA.
AC   Q18896;
DT   01-NOV-1996 (TrEMBLrel. 01, Created)
DT   01-OCT-2003 (TrEMBLrel. 25, Last sequence update)
DT   01-MAR-2004 (TrEMBLrel. 26, Last annotation update)
DE   Nuclear hormone receptor family protein 137, isoform a.
GN   Name=nhr-137; ORFNames=C56E10.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; 
OC   Rhabditidae; Peloderinae; Caenorhabditis. 
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Bristol N2;
RX   MEDLINE=99069613; PubMed=9851916 [NCBI, ExPASy, EBI, Israel, Japan];
RG   WormBase Consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology. The C. elegans Sequencing Consortium.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Bristol N2;
RA   Wilcox L.;
RT   "The sequence of C. elegans cosmid C56E10.";
RL   Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Bristol N2;
RA   Waterston R.;
RL   Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Bristol N2;
RA   Wilson R.;
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Bristol N2;
RA   Wilson R.;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Bristol N2;
RA   Wilson R.;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Bristol N2;
RG   WormBase Consortium;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Receptor for both mineralocorticoids (MC) such as
CC       aldosterone and glucocorticoids (GC) such as corticosterone or
CC       cortisol. Binds to mineralocorticoid response elements (MRE) and
CC       transactivates target genes. The effect of MC is to increase ion
CC       and water transport and thus raise extracellular fluid volume and
CC       blood pressure and lower potassium levels (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nuclear (By similarity).
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
DR   EMBL; U40160; AAA81157.2; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   PIR; T15858; T15858.
DR   Ensembl; C56E10.4; Caenorhabditis elegans. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   WormBase; WBGene00003727; C56E10.4.
DR   WormPep; C56E10.4a; CE34281. [WormPep / WormBase / WorfDB]
DR   GO; GO:0005634; C:nucleus; IEA.
DR   GO; GO:0004872; F:receptor activity; IEA.
DR   GO; GO:0003707; F:steroid hormone receptor activity; IEA.
DR   GO; GO:0003700; F:transcription factor activity; IEA.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA.
DR   GO; GO:0006350; P:transcription; IEA.
DR   InterPro; IPR000536; Hrmon_recept_lig.
DR   InterPro; IPR001628; Znf_C4steroid.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   Pfam; Graphical view of domain structure.
DR   SMART; SM00430; HOLI; 1.
DR   CMR; Q18896.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain]
DR   ProtoMap; Q18896.
DR   PRESAGE; Q18896.
DR   ModBase; Q18896.
DR   SMR; Q18896.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   DNA-binding; Metal-binding; Nuclear protein; Receptor; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
SQ   SEQUENCE   363 AA;  41399 MW;  A49EB981ABD751C3 CRC64;
     MWQKCPRQKH LGFDIRDQSE FVEQMALSVF VLFFLIVLFP EQGFMCFVSG ARIKCRSCRL
     DRCLQQGMRK EAVTSGIVGN EEKVAPQTAY LASISLPSTS TAIPKVTETA SCLRQTLRLI
     TKFRKCNIIV EKIDLHISAL LTMPSFLDNL NNYQEETDFK RDLPEWCTID LLCAIEFAKK
     LPDLSKFSDS DKEELIRNSC FTIAIAIEAI ESYFDKKKTV VMPDGTDVMQ SLANSGSVIH
     AVFTQMFVCI LDPLHRESFT IDELVLTLQL LFFTIAAPEN LTPEGKEQLE KSVKSSMHCL
     MVLLITQNTT NFSARYGSLI ALNETFIKTA HAHKQKMKEA EHSRQKFRDF LIEQCVFDYR
     PAK
//