Swiss-Prot entry

ID   PXR_RAT        STANDARD;      PRT;   431 AA.
AC   Q9R1A7;
DT   16-OCT-2001 (Rel. 40, Created)
DT   16-OCT-2001 (Rel. 40, Last sequence update)
DT   01-MAY-2005 (Rel. 47, Last annotation update)
DE   Orphan nuclear receptor PXR (Pregnane X receptor).
GN   Name=Nr1i2; Synonyms=Pxr;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; 
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; 
OC   Muridae; Murinae; Rattus. 
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Sprague-Dawley;
RX   MEDLINE=99345883; PubMed=10415106 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1006/abbi.1999.1307;
RA   Zhang H., LeCulyse E., Liu L., Hu M., Matoney L., Zhu W., Yan B.;
RT   "Rat pregnane X receptor: molecular cloning, tissue distribution, and
RT   xenobiotic regulation.";
RL   Arch. Biochem. Biophys. 368:14-22(1999).
CC   -!- FUNCTION: Orphan receptor; its natural ligand is probably
CC       pregnane. Binds to a response element in CYP3A genes promoter (By
CC       similarity).
CC   -!- SUBUNIT: Forms a heterodimer with RXR (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nuclear (By similarity).
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
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DR   EMBL; AF151377; AAD47214.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   HSSP; O75469; 1M13. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR   SMR; Q9R1A7; 139-429.
DR   TRANSFAC; T04629; -.
DR   Ensembl; ENSRNOG00000002906; Rattus_norvegicus
DR   GO; GO:0004879; F:ligand-dependent nuclear receptor activity; IDA.
DR   InterPro; IPR000536; Hrmon_recept_lig.
DR   InterPro; IPR001723; Stdhrmn_receptor.
DR   InterPro; IPR008946; Str_ncl_receptor.
DR   InterPro; IPR000324; VitD_receptor.
DR   InterPro; IPR001628; Znf_C4steroid.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   PRINTS; PR00350; VITAMINDR.
DR   ProDom; PD000035; Znf_C4steroid; 1.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR   CMR; Q9R1A7.
DR   HOVERGEN [Family / Alignment / Tree]
DR   BLOCKS; Q9R1A7.
DR   ProtoNet; Q9R1A7.
DR   ProtoMap; Q9R1A7.
DR   PRESAGE; Q9R1A7.
DR   DIP; Q9R1A7.
DR   ModBase; Q9R1A7.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   DNA-binding; Nuclear protein; Receptor; Transcription;
KW   Transcription regulation; Zinc-finger.
FT   DNA_BIND     38    104       Nuclear receptor-type.
FT   ZN_FING      38     58       C4-type.
FT   DOMAIN       63     89       Bipartite nuclear localization signal (By
FT                                similarity).
FT   ZN_FING      74     99       C4-type.
FT   DOMAIN      105    201       Hinge.
FT   DOMAIN      202    431       Ligand-binding.
SQ   SEQUENCE   431 AA;  49660 MW;  4B545F21F9439697 CRC64;
     MRPEERWNHV GLVQREEADS VLEEPINVDE EDGGLQICRV CGDKANGYHF NVMTCEGCKG
     FFRRAMKRNV RLRCPFRKGT CEITRKTRRQ CQACRLRKCL ESGMKKEMIM SDAAVEQRRA
     LIKRKKREKI EAPPPGGQGL TEEQQALIQE LMDAQMQTFD TTFSHFKDFR LPAVFHSDCE
     LPEVLQASLL EDPATWSQIM KDSVPMKISV QLRGEDGSIW NYQPPSKSDG KEIIPLLPHL
     ADVSTYMFKG VINFAKVISH FRELPIEDQI SLLKGATFEM CILRFNTMFD TETGTWECGR
     LAYCFEDPNG GFQKLLLDPL MKFHCMLKKL QLREEEYVLM QAISLFSPDR PGVVQRSVVD
     QLQERFALTL KAYIECSRPY PAHRFLFLKI MAVLTELRSI NAQQTQQLLR IQDTHPFATP
     LMQELFSSTD G
//