Swiss-Prot entry
ID PXR_MOUSE STANDARD; PRT; 431 AA.
AC O54915;
DT 15-JUL-1999 (Rel. 38, Created)
DT 15-JUL-1999 (Rel. 38, Last sequence update)
DT 01-MAY-2005 (Rel. 47, Last annotation update)
DE Orphan nuclear receptor PXR (Pregnane X receptor).
GN Name=Nr1i2; Synonyms=Pxr;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muridae; Murinae; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE, AND ALTERNATIVE SPLICING.
RC TISSUE=Liver;
RX MEDLINE=98149345; PubMed=9489701 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1016/S0092-8674(00)80900-9;
RA Kliewer S.A., Moore J.T., Wade L., Staudinger J.L., Watson M.A.,
RA Jones S.A., McKee D.D., Oliver B.B., Willson T.M., Zetterstrom R.H.,
RA Perlmann T., Lehmann J.M.;
RT "An orphan nuclear receptor activated by pregnanes defines a novel
RT steroid signaling pathway.";
RL Cell 92:73-82(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Cecum;
RX MEDLINE=22354683; PubMed=12466851 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1038/nature01266;
RA Okazaki Y., Furuno M., Kasukawa T., Adachi J., Bono H., Kondo S.,
RA Nikaido I., Osato N., Saito R., Suzuki H., Yamanaka I., Kiyosawa H.,
RA Yagi K., Tomaru Y., Hasegawa Y., Nogami A., Schonbach C., Gojobori T.,
RA Baldarelli R., Hill D.P., Bult C., Hume D.A., Quackenbush J.,
RA Schriml L.M., Kanapin A., Matsuda H., Batalov S., Beisel K.W.,
RA Blake J.A., Bradt D., Brusic V., Chothia C., Corbani L.E., Cousins S.,
RA Dalla E., Dragani T.A., Fletcher C.F., Forrest A., Frazer K.S.,
RA Gaasterland T., Gariboldi M., Gissi C., Godzik A., Gough J.,
RA Grimmond S., Gustincich S., Hirokawa N., Jackson I.J., Jarvis E.D.,
RA Kanai A., Kawaji H., Kawasawa Y., Kedzierski R.M., King B.L.,
RA Konagaya A., Kurochkin I.V., Lee Y., Lenhard B., Lyons P.A.,
RA Maglott D.R., Maltais L., Marchionni L., McKenzie L., Miki H.,
RA Nagashima T., Numata K., Okido T., Pavan W.J., Pertea G., Pesole G.,
RA Petrovsky N., Pillai R., Pontius J.U., Qi D., Ramachandran S.,
RA Ravasi T., Reed J.C., Reed D.J., Reid J., Ring B.Z., Ringwald M.,
RA Sandelin A., Schneider C., Semple C.A., Setou M., Shimada K.,
RA Sultana R., Takenaka Y., Taylor M.S., Teasdale R.D., Tomita M.,
RA Verardo R., Wagner L., Wahlestedt C., Wang Y., Watanabe Y., Wells C.,
RA Wilming L.G., Wynshaw-Boris A., Yanagisawa M., Yang I., Yang L.,
RA Yuan Z., Zavolan M., Zhu Y., Zimmer A., Carninci P., Hayatsu N.,
RA Hirozane-Kishikawa T., Konno H., Nakamura M., Sakazume N., Sato K.,
RA Shiraki T., Waki K., Kawai J., Aizawa K., Arakawa T., Fukuda S.,
RA Hara A., Hashizume W., Imotani K., Ishii Y., Itoh M., Kagawa I.,
RA Miyazaki A., Sakai K., Sasaki D., Shibata K., Shinagawa A.,
RA Yasunishi A., Yoshino M., Waterston R., Lander E.S., Rogers J.,
RA Birney E., Hayashizaki Y.;
RT "Analysis of the mouse transcriptome based on functional annotation of
RT 60,770 full-length cDNAs.";
RL Nature 420:563-573(2002).
CC -!- FUNCTION: Orphan receptor; its natural ligand is probably
CC pregnane. Binds to a response element in CYP3A genes promoter.
CC -!- SUBUNIT: Forms a heterodimer with RXR.
CC -!- SUBCELLULAR LOCATION: Nuclear (By similarity).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=PXR.1;
CC IsoId=O54915-1; Sequence=Displayed;
CC Name=2; Synonyms=PXR.2;
CC IsoId=O54915-2; Sequence=VSP_003670;
CC -!- INDUCTION: Activated by naturally occurring steroids such as
CC pregnenolone and progesterone, synthetic glucocorticoids and
CC antiglucocorticoids and 16-alpha-carbonitrile (PCN).
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC subfamily.
CC -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
CC --------------------------------------------------------------------------
CC This Swiss-Prot entry is copyright. It is produced through a collaboration
CC between the Swiss Institute of Bioinformatics and the EMBL outstation -
CC the European Bioinformatics Institute. There are no restrictions on its
CC use as long as its content is in no way modified and this statement is not
CC removed.
CC --------------------------------------------------------------------------
DR EMBL; AF031814; AAC39964.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; AK018630; BAB31316.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR HSSP; O75469; 1M13. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR SMR; O54915; 139-429.
DR TRANSFAC; T04618; -.
DR TRANSFAC; T04619; -.
DR Ensembl; ENSMUSG00000022809; Mus_musculus
DR MGD; MGI:1337040; Nr1i2.
DR GeneLynx; Nr1i2..
DR SOURCE; Nr1i2..
DR InterPro; IPR000536; Hrmon_recept_lig.
DR InterPro; IPR001723; Stdhrmn_receptor.
DR InterPro; IPR008946; Str_ncl_receptor.
DR InterPro; IPR000324; VitD_receptor.
DR InterPro; IPR001628; Znf_C4steroid.
DR InterPro; Graphical view of domain structure.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR Pfam; Graphical view of domain structure.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR PRINTS; PR00350; VITAMINDR.
DR ProDom; PD000035; Znf_C4steroid; 1.
DR ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR CMR; O54915.
DR HOVERGEN [Family / Alignment / Tree]
DR BLOCKS; O54915.
DR ProtoNet; O54915.
DR ProtoMap; O54915.
DR PRESAGE; O54915.
DR DIP; O54915.
DR ModBase; O54915.
DR SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW Alternative splicing; DNA-binding; Nuclear protein; Receptor;
KW Transcription; Transcription regulation; Zinc-finger.
FT DNA_BIND 35 104 Nuclear receptor-type.
FT ZN_FING 38 58 C4-type.
FT DOMAIN 63 89 Bipartite nuclear localization signal (By
FT similarity).
FT ZN_FING 74 99 C4-type.
FT DOMAIN 105 201 Hinge.
FT DOMAIN 202 431 Ligand-binding.
FT VARSPLIC 171 211 Missing (in isoform 2).
FT /FTId=VSP_003670.
SQ SEQUENCE 431 AA; 49567 MW; F592AF91F689329E CRC64;
MRPEESWSRV GLVQCEEADS ALEEPINVEE EDGGLQICRV CGDKANGYHF NVMTCEGCKG
FFRRAMKRNV RLRCPFRKGT CEITRKTRRQ CQACRLRKCL ESGMKKEMIM SDAAVEQRRA
LIKRKKREKI EAPPPGGQGL TEEQQALIQE LMDAQMQTFD TTFSHFKDFR LPAVFHSGCE
LPEFLQASLL EDPATWSQIM KDRVPMKISL QLRGEDGSIW NYQPPSKSDG KEIIPLLPHL
ADVSTYMFKG VINFAKVISY FRDLPIEDQI SLLKGATFEM CILRFNTMFD TETGTWECGR
LAYCFEDPNG GFQKLLLDPL MKFHCMLKKL QLHKEEYVLM QAISLFSPDR PGVVQRSVVD
QLQERFALTL KAYIECSRPY PAHRFLFLKI MAVLTELRSI NAQQTQQLLR IQDSHPFATP
LMQELFSSTD G
//