Swiss-Prot entry

ID   PPAT_MACMU     STANDARD;      PRT;   505 AA.
AC   O18924; Q9TQW6;
DT   16-OCT-2001 (Rel. 40, Created)
DT   16-OCT-2001 (Rel. 40, Last sequence update)
DT   01-MAY-2005 (Rel. 47, Last annotation update)
DE   Peroxisome proliferator activated receptor gamma (PPAR-gamma).
GN   Name=PPARG; Synonyms=NR1C3;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; 
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini; 
OC   Cercopithecidae; Cercopithecinae; Macaca. 
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE (ISOFORMS 1 AND 2).
RC   TISSUE=Adipose tissue;
RX   MEDLINE=99021153; PubMed=9806316 [NCBI, ExPASy, EBI, Israel, Japan];
RA   Hotta K., Gustafson T.A., Yoshioka S., Ortmeyer H.K., Bodkin N.L.,
RA   Hansen B.C.;
RT   "Relationships of PPARgamma and PPARgamma2 mRNA levels to obesity,
RT   diabetes and hyperinsulinaemia in rhesus monkeys.";
RL   Int. J. Obes. Relat. Metab. Disord. 22:1000-1010(1998).
CC   -!- FUNCTION: Receptor that binds peroxisome proliferators such as
CC       hypolipidemic drugs and fatty acids. Once activated by a ligand,
CC       the receptor binds to a promoter element in the gene for acyl-CoA
CC       oxidase and activates its transcription. It therefore controls the
CC       peroxisomal beta-oxidation pathway of fatty acids. Key regulator
CC       of adipocyte differentiation and glucose homeostasis.
CC   -!- SUBUNIT: Forms a heterodimer with the retinoic acid receptor RXR-
CC       alpha called adipocyte-specific transcription factor ARF6.
CC       Interacts with NCOA6 coactivator, leading to a strong increase in
CC       transcription of target genes (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nuclear.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC         Comment=Additional isoforms seem to exist;
CC       Name=2;
CC         IsoId=O18924-1; Sequence=Displayed;
CC       Name=1;
CC         IsoId=O18924-2; Sequence=VSP_003646;
CC   -!- TISSUE SPECIFICITY: Highest expression in adipose tissue. Lower in
CC       liver, heart, kidney, stomach, duodenum and colon.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; AF033103; AAB87480.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   EMBL; AF033343; AAB87482.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   EMBL; AF033342; AAB87481.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   HSSP; Q96J12; 1FM9. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR   SMR; O18924; 234-505.
DR   InterPro; IPR000536; Hrmon_recept_lig.
DR   InterPro; IPR001723; Stdhrmn_receptor.
DR   InterPro; IPR008946; Str_ncl_receptor.
DR   InterPro; IPR001628; Znf_C4steroid.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR01288; PROXISOMEPAR.
DR   PRINTS; PR01291; PROXISOMPAGR.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   ProDom; PD000035; Znf_C4steroid; 1.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR   HOVERGEN [Family / Alignment / Tree]
DR   BLOCKS; O18924.
DR   ProtoNet; O18924.
DR   ProtoMap; O18924.
DR   PRESAGE; O18924.
DR   DIP; O18924.
DR   ModBase; O18924.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   Activator; Alternative splicing; DNA-binding; Multigene family;
KW   Nuclear protein; Phosphorylation; Receptor; Transcription;
KW   Transcription regulation; Zinc-finger.
FT   DNA_BIND    136    210       Nuclear receptor-type.
FT   ZN_FING     139    159       C4-type.
FT   ZN_FING     176    198       C4-type.
FT   DOMAIN      318    505       Ligand-binding (Potential).
FT   MOD_RES     112    112       Phosphoserine (by MAPK) (By similarity).
FT   VARSPLIC      1     30       Missing (in isoform 1).
FT                                /FTId=VSP_003646.
SQ   SEQUENCE   505 AA;  57590 MW;  41836A624AAF6942 CRC64;
     MGETLGDSPI DPESDSFTDT LSANISQEIT MVDTEMPFWP TNFGISSVDL SVMDDHSHSF
     DIKPFTTVDF SSISAPHYED IPFTRTDPMV ADYKYDLKLQ EYQSAIKVEP ASPPYYSEKT
     QLYNKPHEEP SNSLMAIECR VCGDKASGFH YGVHACEGCK GFFRRTIRLK LIYDRCDLNC
     RIHKKSRNKC QYCRFQKCLA VGMSHNAIRF GRMPQAEKEK LLAEISSDID QLNPESADLR
     ALAKHLYDSY IKSFPLTKAK ARAILTGKTT DKSPFVIYDM NSLMMGEDKI KFKHITPLQE
     QSKEVAIRIF QGCQFRSVEA VQEITEYAKS IPGFVNLDLN DQVTLLKYGV HEIIYTMLAS
     LMNKDGVLIS EGQGFMTREF LKSLRKPFGD FMEPKFEFAV KFNALELDDS DLAIFIAVII
     LSGDRPGLLN VKPIEDIQDN LLQALELQLK LNHPESSQLF AKLLQKMTDL RQIVTEHVQL
     LQVIKKTETD MSLHPLLQEI YKDLY
//