Swiss-Prot entry

ID   PPAS_XENLA     STANDARD;      PRT;   396 AA.
AC   P37233;
DT   01-OCT-1994 (Rel. 30, Created)
DT   01-OCT-1994 (Rel. 30, Last sequence update)
DT   01-MAY-2005 (Rel. 47, Last annotation update)
DE   Peroxisome proliferator activated receptor beta (PPAR-beta).
GN   Name=PPARB; Synonyms=NR1C2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; 
OC   Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae; 
OC   Xenopodinae; Xenopus; Xenopus. 
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=92191267; PubMed=1312391 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1016/0092-8674(92)90031-7;
RA   Dreyer C., Krey G., Keller H., Givel F., Helftenbein G., Wahli W.;
RT   "Control of the peroxisomal beta-oxidation pathway by a novel family
RT   of nuclear hormone receptors.";
RL   Cell 68:879-887(1992).
RN   [2]
RP   CHARACTERIZATION.
RX   MEDLINE=94100165; PubMed=8274443 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1016/0960-0760(93)90058-5;
RA   Krey G., Keller H., Mahfoudi A., Medin J., Ozato K., Dreyer C.,
RA   Wahli W.;
RT   "Xenopus peroxisome proliferator activated receptors: genomic
RT   organization, response element recognition, heterodimer formation with
RT   retinoid X receptor and activation by fatty acids.";
RL   J. Steroid Biochem. Mol. Biol. 47:65-73(1993).
CC   -!- FUNCTION: Receptor that binds peroxisome proliferators such as
CC       hypolipidemic drugs and fatty acids. Once activated by a ligand,
CC       the receptor binds to a promoter element in the gene for acyl-CoA
CC       oxidase and activates its transcription. It therefore controls the
CC       peroxisomal beta-oxidation pathway of fatty acids.
CC   -!- SUBUNIT: Heterodimer with the retinoid X receptor.
CC   -!- SUBCELLULAR LOCATION: Nuclear.
CC   -!- TISSUE SPECIFICITY: Ubiquitous.
CC   -!- DEVELOPMENTAL STAGE: Oocytes, embryos, and adults.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
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DR   EMBL; M84162; AAA49936.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   PIR; B42214; B42214.
DR   HSSP; Q96J12; 1I7I. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR   TRANSFAC; T01353; -.
DR   InterPro; IPR000536; Hrmon_recept_lig.
DR   InterPro; IPR001723; Stdhrmn_receptor.
DR   InterPro; IPR008946; Str_ncl_receptor.
DR   InterPro; IPR001628; Znf_C4steroid.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR01288; PROXISOMEPAR.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   ProDom; PD000035; Znf_C4steroid; 1.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR   HOVERGEN [Family / Alignment / Tree]
DR   BLOCKS; P37233.
DR   ProtoNet; P37233.
DR   ProtoMap; P37233.
DR   PRESAGE; P37233.
DR   DIP; P37233.
DR   ModBase; P37233.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   Activator; DNA-binding; Multigene family; Nuclear protein; Receptor;
KW   Transcription; Transcription regulation; Zinc-finger.
FT   DNA_BIND     28    102       Nuclear receptor-type.
FT   ZN_FING      31     51       C4-type.
FT   ZN_FING      68     90       C4-type.
FT   DOMAIN      209    396       Ligand-binding (Potential).
SQ   SEQUENCE   396 AA;  44992 MW;  D2F626BE07EBD750 CRC64;
     MKEEIPPRSP ILDEQPSTPL EHQETSQSVD CKICGDRASG FHYGVHACEG CKGFFRRTIR
     MRLQYEHCDR NCKIQKKNRN KCQYCRFNKC LSLGMSHNAI RFGRMPESEK RKLVQAPVSD
     SAAPDSPVSD LDVLSQLIHS SYMNTFTMTK KRARDILTGR NSISPFVIHD MDTLWQAEQG
     TVWEQLPTQN LTGTEIGVHV FYRCQCTSVE TVRALTDFAK RIPGFGTLYL NDQVTLLKYG
     VHEAIFCMLA SLMNKDGLLV AGGRGFVTRE FLRSLRQPFC HIMEPKFHFA SKFNALELND
     SDLALFVASI ILCGDRPGLI NPSQVEDIQE GILGALRRHL KASHTDAPFL FPKLLHKMAD
     LRQLVTEHAE LVQSIKRTES SAALHPLLQE IYRDMY
//