Swiss-Prot entry

ID   PPAR_XENLA     STANDARD;      PRT;   474 AA.
AC   P37232;
DT   01-OCT-1994 (Rel. 30, Created)
DT   01-OCT-1994 (Rel. 30, Last sequence update)
DT   01-MAY-2005 (Rel. 47, Last annotation update)
DE   Peroxisome proliferator activated receptor alpha (PPAR-alpha).
GN   Name=PPARA; Synonyms=NR1C1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; 
OC   Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae; 
OC   Xenopodinae; Xenopus; Xenopus. 
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=92191267; PubMed=1312391 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1016/0092-8674(92)90031-7;
RA   Dreyer C., Krey G., Keller H., Givel F., Helftenbein G., Wahli W.;
RT   "Control of the peroxisomal beta-oxidation pathway by a novel family
RT   of nuclear hormone receptors.";
RL   Cell 68:879-887(1992).
RN   [2]
RP   CHARACTERIZATION.
RX   MEDLINE=94100165; PubMed=8274443 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1016/0960-0760(93)90058-5;
RA   Krey G., Keller H., Mahfoudi A., Medin J., Ozato K., Dreyer C.,
RA   Wahli W.;
RT   "Xenopus peroxisome proliferator activated receptors: genomic
RT   organization, response element recognition, heterodimer formation with
RT   retinoid X receptor and activation by fatty acids.";
RL   J. Steroid Biochem. Mol. Biol. 47:65-73(1993).
CC   -!- FUNCTION: Receptor that binds peroxisome proliferators such as
CC       hypolipidemic drugs and fatty acids. Once activated by a ligand,
CC       the receptor binds to a promoter element in the gene for acyl-CoA
CC       oxidase and activates its transcription. It therefore controls the
CC       peroxisomal beta-oxidation pathway of fatty acids.
CC   -!- SUBUNIT: Heterodimer with the retinoid X receptor.
CC   -!- SUBCELLULAR LOCATION: Nuclear.
CC   -!- TISSUE SPECIFICITY: Ubiquitous.
CC   -!- DEVELOPMENTAL STAGE: Oocytes, embryos, and adults.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
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DR   EMBL; M84161; AAA49935.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   PIR; A42214; A42214.
DR   HSSP; Q07869; 1KKQ. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR   SMR; P37232; 209-474.
DR   TRANSFAC; T01352; -.
DR   InterPro; IPR000536; Hrmon_recept_lig.
DR   InterPro; IPR001723; Stdhrmn_receptor.
DR   InterPro; IPR008946; Str_ncl_receptor.
DR   InterPro; IPR001628; Znf_C4steroid.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR01288; PROXISOMEPAR.
DR   PRINTS; PR01289; PROXISOMPAAR.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   ProDom; PD000035; Znf_C4steroid; 1.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR   HOVERGEN [Family / Alignment / Tree]
DR   BLOCKS; P37232.
DR   ProtoNet; P37232.
DR   ProtoMap; P37232.
DR   PRESAGE; P37232.
DR   DIP; P37232.
DR   ModBase; P37232.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   Activator; DNA-binding; Multigene family; Nuclear protein; Receptor;
KW   Transcription; Transcription regulation; Zinc-finger.
FT   DNA_BIND    106    180       Nuclear receptor-type.
FT   ZN_FING     109    129       C4-type.
FT   ZN_FING     146    168       C4-type.
FT   DOMAIN      287    474       Ligand-binding (Potential).
SQ   SEQUENCE   474 AA;  52856 MW;  4DBB941318D43483 CRC64;
     MSTIMVDTNS ELCILTPLDE DDLESPLSGE FLQDIVDIQD ITQTIGDDGS TPFGASEHQF
     FGNSPGSIGS VSTDLTDTLS PASSPASITF PAASGSAEDA ACKSLNLECR VCSDKASGFH
     YGVHACEGCK GFFRRTIRLK LVYDRCERMC KIQKKNRNKC QYCRFEKCLN VGMSHNAIRF
     GRMPRSEKAK LKAEVLMCDQ DVKDSQMADL LSLARLIYDA YLKNFNMNKV KARAILTGKA
     SNPPFVIHDM ETLCMAEKTL VAKLVANGIQ NKEAEVRIFH CCQCTSVETV TELTEFAKSI
     PGFTELDLND QVTLLKYGVY EAMFAMLASV MNKDGMLVAY GNGFITREFL KSLRKPIGDM
     MEPKFEFAMK FNALELDDSD LSLFVAALIC CGDRPGLVNI PSIEKMQESI VHVLKLHLQS
     NHPDDSFLFP KLLQKMADLR QLVTEHAQLV QTIKKTETDA ALHPLLQEIY RDMY
//