Swiss-Prot entry

ID   PPAR_PHACI     STANDARD;      PRT;   468 AA.
AC   Q8HYL6;
DT   10-OCT-2003 (Rel. 42, Created)
DT   10-OCT-2003 (Rel. 42, Last sequence update)
DT   01-MAY-2005 (Rel. 47, Last annotation update)
DE   Peroxisome proliferator activated receptor alpha (PPAR-alpha).
GN   Name=PPARA; Synonyms=NR1C1;
OS   Phascolarctos cinereus (Koala).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; 
OC   Mammalia; Metatheria; Diprotodontia; Phascolarctidae; Phascolarctos. 
OX   NCBI_TaxID=38626;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Liver;
RA   Ngo S.N.T., McKinnon R.A., Stupans I.;
RT   "Koala liver peroxisome proliferator activated receptor alpha (PPAR-
RT   alpha) full-length cDNA.";
RL   Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Receptor that binds peroxisome proliferators such as
CC       hypolipidemic drugs and fatty acids. Once activated by a ligand,
CC       the receptor binds to a promoter element in the gene for acyl-CoA
CC       oxidase and activates its transcription. It therefore controls the
CC       peroxisomal beta-oxidation pathway of fatty acids (By similarity).
CC   -!- SUBUNIT: Heterodimer with the retinoid X receptor (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nuclear (By similarity).
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; AF463455; AAO15578.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   HSSP; Q07869; 1I7G. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR   SMR; Q8HYL6; 202-468.
DR   InterPro; IPR000536; Hrmon_recept_lig.
DR   InterPro; IPR001723; Stdhrmn_receptor.
DR   InterPro; IPR008946; Str_ncl_receptor.
DR   InterPro; IPR001628; Znf_C4steroid.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR01288; PROXISOMEPAR.
DR   PRINTS; PR01289; PROXISOMPAAR.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   ProDom; PD000035; Znf_C4steroid; 1.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR   HOVERGEN [Family / Alignment / Tree]
DR   BLOCKS; Q8HYL6.
DR   ProtoNet; Q8HYL6.
DR   ProtoMap; Q8HYL6.
DR   PRESAGE; Q8HYL6.
DR   DIP; Q8HYL6.
DR   ModBase; Q8HYL6.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   Activator; DNA-binding; Multigene family; Nuclear protein; Receptor;
KW   Transcription; Transcription regulation; Zinc-finger.
FT   DNA_BIND     99    173       Nuclear receptor-type.
FT   ZN_FING     102    122       C4-type.
FT   ZN_FING     139    161       C4-type.
FT   DOMAIN      281    468       Ligand-binding (Potential).
SQ   SEQUENCE   468 AA;  52199 MW;  CBFDDCEE1F726ED5 CRC64;
     MVDTESQICP LSPFGDDDLE SPLSEEFLQE MGSIQEISPS IGDDSSGTFA FAEYRCLGSG
     PGSDGSIITD TLSPASSPSS VSYTPIAGSA DDSSSATLNI ECRICGDKAS GYHYGVHACE
     GCKGFFRRTI RLKLAYDKCD RSCKIQKKNR NKCQYCRFQK CLSDGMSHNA IRFGRMPRSE
     KAKLKAEILT CEHDLEDSEV ADLKSLAKRI YEAYLKNFNM NKIKARIILA GKASNNPPFV
     IHDMETLCMA EKTLVAKLVA NGIQNKEAEV RIFHCCQCTS VETVTELTEF AKSIPGFSNL
     NLNDQVTLLK YGVYEAIFAM LSSVMNKDGM LVAYGNGFIT REFLKSLRKP FCDIMEPKFD
     FAMKFNALEL DDSDISLFVA AIICCGDRPG LLNVGHIERM QESIVHVLQL HLQNNHPDDV
     FLFPKLLQKM ADLRQLVTEH AQLVQVIKKT ESDAALHPLL QEIYRDMY
//