Swiss-Prot entry

ID   PPAR_CAVPO     STANDARD;      PRT;   467 AA.
AC   O35507;
DT   15-JUL-1998 (Rel. 36, Created)
DT   15-JUL-1998 (Rel. 36, Last sequence update)
DT   01-MAY-2005 (Rel. 47, Last annotation update)
DE   Peroxisome proliferator activated receptor alpha (PPAR-alpha).
GN   Name=PPARA; Synonyms=NR1C1;
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; 
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; 
OC   Hystricognathi; Caviidae; Cavia. 
OX   NCBI_TaxID=10141;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Dunkin-Hartley; TISSUE=Liver;
RX   MEDLINE=98178962; PubMed=9520140 [NCBI, ExPASy, EBI, Israel, Japan];
RA   Tugwood J.D., Holden P.R., James N.H., Prince R.A., Roberts R.A.;
RT   "A peroxisome proliferator-activated receptor-alpha (PPARalpha) cDNA
RT   cloned from guinea-pig liver encodes a protein with similar properties
RT   to the mouse PPARalpha: implications for species differences in
RT   responses to peroxisome proliferators.";
RL   Arch. Toxicol. 72:169-177(1998).
CC   -!- FUNCTION: Receptor that binds peroxisome proliferators such as
CC       hypolipidemic drugs and fatty acids. Once activated by a ligand,
CC       the receptor binds to a promoter element in the gene for acyl-CoA
CC       oxidase and activates its transcription. It therefore controls the
CC       peroxisomal beta-oxidation pathway of fatty acids (By similarity).
CC   -!- SUBUNIT: Heterodimer with the retinoid X receptor. Interacts with
CC       NCOA3 and NCOA6 coactivators, leading to a strong increase of
CC       transcription of target genes (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nuclear.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; AJ000222; CAA03951.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   HSSP; Q07869; 1I7G. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR   SMR; O35507; 200-467.
DR   InterPro; IPR000536; Hrmon_recept_lig.
DR   InterPro; IPR001723; Stdhrmn_receptor.
DR   InterPro; IPR008946; Str_ncl_receptor.
DR   InterPro; IPR001628; Znf_C4steroid.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR01288; PROXISOMEPAR.
DR   PRINTS; PR01289; PROXISOMPAAR.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   ProDom; PD000035; Znf_C4steroid; 1.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR   HOVERGEN [Family / Alignment / Tree]
DR   BLOCKS; O35507.
DR   ProtoNet; O35507.
DR   ProtoMap; O35507.
DR   PRESAGE; O35507.
DR   DIP; O35507.
DR   ModBase; O35507.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   Activator; DNA-binding; Multigene family; Nuclear protein; Receptor;
KW   Transcription; Transcription regulation; Zinc-finger.
FT   DNA_BIND     99    173       Nuclear receptor-type.
FT   ZN_FING     102    122       C4-type.
FT   ZN_FING     139    161       C4-type.
FT   DOMAIN      281    467       Ligand-binding (Potential).
SQ   SEQUENCE   467 AA;  52313 MW;  D55DD2A6ED0205DE CRC64;
     MVDMESPLCP LSPLEAEDLE SPLSEYFLQE MGTIQDISRS LGEDSSGSFG FPEYQYLGSG
     PGSDGSVITD TLSPASSPSS VSYPEVPCGV DEPPSSALNI ECRICGDKAS GYHYGVHACE
     GCKGFFRRTI RLKLVYDKCD RSCKIQKKNR NKCQYCRFHK CLSVGMSHNA IRFGRMPRSE
     KAKLKAEVLT CDRDSEGAET ADLKSLAKRI YEAYLKNFHM NKVKARIILA GKTSSHPLFV
     IHDMETLCTA EKTLMAKVVS DGIRDKEAEV RIFHCCQCVS VETVTNLTEF AKAIPGFASL
     DLNDQVTLLK YGVYEAIFTM LSSTMNKDGM LVAYGHGFIT REFLKNLRKP FCDMMEPKFN
     FAMKFNALEL DDSDISLFVA AIICCGDRPG LLNIDHIEKM QEAIVHVLKL HLQSNHPDDT
     FLFPKLLQKL ADLRQLVTEH AQLVQVIKTE SDAALHPLLQ EIYRDMY
//