Swiss-Prot entry

ID   O16960_CAEEL PRELIMINARY;      PRT;   393 AA.
AC   O16960;
DT   01-JAN-1998 (TrEMBLrel. 05, Created)
DT   01-JAN-1998 (TrEMBLrel. 05, Last sequence update)
DT   01-OCT-2003 (TrEMBLrel. 25, Last annotation update)
DE   Nuclear hormone receptor family protein 58, isoform a.
GN   Name=nhr-58; ORFNames=R11G11.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; 
OC   Rhabditidae; Peloderinae; Caenorhabditis. 
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Bristol N2;
RX   MEDLINE=99069613; PubMed=9851916 [NCBI, ExPASy, EBI, Israel, Japan];
RG   WormBase Consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology. The C. elegans Sequencing Consortium.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Bristol N2;
RA   Davidson S., Wohldmann P., Bauer C.;
RT   "The sequence of C. elegans cosmid R11G11.";
RL   Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Bristol N2;
RA   Waterston R.;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Bristol N2;
RA   Wilson R.;
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Bristol N2;
RA   Wilson R.;
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Bristol N2;
RG   WormBase Consortium;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Receptor for both mineralocorticoids (MC) such as
CC       aldosterone and glucocorticoids (GC) such as corticosterone or
CC       cortisol. Binds to mineralocorticoid response elements (MRE) and
CC       transactivates target genes. The effect of MC is to increase ion
CC       and water transport and thus raise extracellular fluid volume and
CC       blood pressure and lower potassium levels (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nuclear (By similarity).
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
DR   EMBL; AF022976; AAC69077.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   PIR; E88931; E88931.
DR   HSSP; P19793; 2NLL. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR   Ensembl; R11G11.2; Caenorhabditis elegans. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   WormBase; WBGene00003648; R11G11.2.
DR   WormPep; R11G11.2a; CE12742. [WormPep / WormBase / WorfDB]
DR   GO; GO:0005634; C:nucleus; IEA.
DR   GO; GO:0004872; F:receptor activity; IEA.
DR   GO; GO:0003707; F:steroid hormone receptor activity; IEA.
DR   GO; GO:0003700; F:transcription factor activity; IEA.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA.
DR   GO; GO:0006350; P:transcription; IEA.
DR   InterPro; IPR000536; Hrmon_recept_lig.
DR   InterPro; IPR001628; Znf_C4steroid.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF00105; zf-C4; 1.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR00047; STROIDFINGER.
DR   ProDom; PD000035; Znf_C4steroid; 1.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   CMR; O16960.
DR   ProtoMap; O16960.
DR   PRESAGE; O16960.
DR   ModBase; O16960.
DR   SMR; O16960.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   DNA-binding; Metal-binding; Nuclear protein; Receptor; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
SQ   SEQUENCE   393 AA;  45648 MW;  F01A8E9AAECDCB4F CRC64;
     MLISIEFCKI CDRKSQGIHF GVPSCRACAA FFRRRAGSDL VEKSCMNKKC GKEFFLCKPC
     RLVRCYAVGM DEKKFQFDRD ALASTVLLNT IPKSFDKFVG RPQFVHFCDP SAPSTSKFID
     VRLLVEKGEN ILKSGPSWTP HMNKGPLFKL ANFHNVFTKM PVNMATNNVF SRGDCSDCWE
     YYFLTTATWL TNFDEFQKLE HPVKMKILFA IWHMWGRMDK LACTALARRR QQLSAKSEIA
     QSNGLFLDVD TLALDVSWIS EFKLEEVEFF IDGFRNWDLM ELVQVFVELD PTPIELNYML
     AQMSFYYAGN RFQGEILEIM DRFQQILSDD LHKYYVNERH TSNYSGRLSR LLKINNAVQS
     SVRKRRPKTD IAKTLNIFTA EFSHPEMFFD TGF
//