Swiss-Prot entry
ID NR5A2_MOUSE STANDARD; PRT; 560 AA.
AC P45448;
DT 01-NOV-1995 (Rel. 32, Created)
DT 30-MAY-2000 (Rel. 39, Last sequence update)
DT 01-MAY-2005 (Rel. 47, Last annotation update)
DE Orphan nuclear receptor NR5A2 (Liver receptor homolog) (LRH-1).
GN Name=Nr5a2; Synonyms=Lrh1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muridae; Murinae; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RA Tugwood J.D., Issemann I., Green S.;
RT "LRH-1: a nuclear hormone receptor active in the absence of exogenous
RT ligands.";
RL Submitted (FEB-1992) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nuclear (Probable).
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR5
CC subfamily.
CC -!- SIMILARITY: Contains 1 FTZ-F1 box domain.
CC -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
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CC This Swiss-Prot entry is copyright. It is produced through a collaboration
CC between the Swiss Institute of Bioinformatics and the EMBL outstation -
CC the European Bioinformatics Institute. There are no restrictions on its
CC use as long as its content is in no way modified and this statement is not
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DR EMBL; M81385; AAA39447.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR PIR; S27874; S27874.
DR PDB; 1PK5; X-ray; A/B=313-560. [ExPASy / RCSB]
DR TRANSFAC; T04754; -.
DR Ensembl; ENSMUSG00000026398; Mus_musculus
DR MGD; MGI:1346834; Nr5a2.
DR GeneLynx; Nr5a2..
DR SOURCE; Nr5a2..
DR GO; GO:0003677; F:DNA binding; IDA.
DR GO; GO:0008206; P:bile acid metabolism; IMP.
DR GO; GO:0042632; P:cholesterol homeostasis; IMP.
DR InterPro; IPR000536; Hrmon_recept_lig.
DR InterPro; IPR001723; Stdhrmn_receptor.
DR InterPro; IPR008946; Str_ncl_receptor.
DR InterPro; IPR000324; VitD_receptor.
DR InterPro; IPR001628; Znf_C4steroid.
DR InterPro; Graphical view of domain structure.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR Pfam; Graphical view of domain structure.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR PRINTS; PR00350; VITAMINDR.
DR ProDom; PD000035; Znf_C4steroid; 1.
DR ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR CMR; P45448.
DR HOVERGEN [Family / Alignment / Tree]
DR BLOCKS; P45448.
DR ProtoNet; P45448.
DR ProtoMap; P45448.
DR PRESAGE; P45448.
DR DIP; P45448.
DR ModBase; P45448.
DR SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW 3D-structure; DNA-binding; Nuclear protein; Receptor; Transcription;
KW Transcription regulation; Zinc-finger.
FT DNA_BIND 104 175 Nuclear receptor-type.
FT ZN_FING 107 127 C4-type.
FT ZN_FING 143 167 C4-type.
FT DOMAIN 176 205 FTZ-F1 box.
SQ SEQUENCE 560 AA; 64020 MW; 186F8C4025934643 CRC64;
MSASLDTGDF QEFLKHGLTA IASAPGSETR HSPKREEQLR EKRAGLPDRH RRPIPARSRL
VMLPKVETEA PGLVRSHGEQ GQMPENMQVS QFKMVNYSYD EDLEELCPVC GDKVSGYHYG
LLTCESCKGF FKRTVQNQKR YTCIENQNCQ IDKTQRKRCP YCRFKKCIDV GMKLEAVRAD
RMRGGRNKFG PMYKRDRALK QQKKALIRAN GLKLEAMSQV IQAMPSDLTS AIQNIHSASK
GLPLSHVALP PTDYDRSPFV TSPISMTMPP HSSLHGYQPY GHFPSRAIKS EYPDPYSSSP
ESMMGYSYMD GYQTNSPASI PHLILELLKC EPDEPQVQAK IMAYLQQEQS NRNRQEKLSA
FGLLCKMADQ TLFSIVEWAR SSIFFRELKV DDQMKLLQNC WSELLILDHI YRQVAHGKEG
TIFLVTGEHV DYSTIISHTE VAFNNLLSLA QELVVRLRSL QFDQREFVCL KFLVLFSSDV
KNLENLQLVE GVQEQVNAAL LDYTVCNYPQ QTEKFGQLLL RLPEIRAISK QAEDYLYYKH
VNGDVPYNNL LIEMLHAKRA
//